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    Lingo1 leucine rich repeat and Ig domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315691, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lingo1provided by RGD
    Official Full Name
    leucine rich repeat and Ig domain containing 1provided by RGD
    Primary source
    RGD:1308668
    See related
    EnsemblRapid:ENSRNOG00000017193 AllianceGenome:RGD:1308668
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Lrrn6a
    Summary
    Predicted to enable epidermal growth factor receptor binding activity. Predicted to act upstream of or within negative regulation of oligodendrocyte differentiation; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and neuron development. Predicted to be located in plasma membrane. Predicted to be active in several cellular components, including extracellular space; glutamatergic synapse; and presynapse. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 64 and glaucoma. Orthologous to human LINGO1 (leucine rich repeat and Ig domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 58.9) and Adrenal (RPKM 1.8) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lingo1 in Genome Data Viewer
    Location:
    8q24
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (65907275..66089485, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (57011272..57193496, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (61272125..61455480, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene pseudopodium-enriched atypical kinase 1 Neighboring gene iron-sulfur cluster assembly 2, pseudogene 2 Neighboring gene high mobility group 20A Neighboring gene uncharacterized LOC120094170 Neighboring gene uncharacterized LOC134480186 Neighboring gene ATP synthase subunit g, mitochondrial-like Neighboring gene ATP synthase membrane subunit G like 1 Neighboring gene uncharacterized LOC134480055 Neighboring gene transfer RNA proline (anticodon AGG) 41 Neighboring gene ciliary microtubule associated protein 1C Neighboring gene chondroitin sulfate proteoglycan 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. LINGO-1 siRNA nanoparticles promote central remyelination in ethidium bromide-induced demyelination in rats. Youssef AEH, et al. J Physiol Biochem, 2019 Feb. PMID 30759305
    2. Alterations of Hippocampal Myelin Sheath and Axon Sprouting by Status Convulsion and Regulating Lingo-1 Expression with RNA Interference in Immature and Adult Rats. Song XJ, et al. Neurochem Res, 2018 Mar. PMID 29383653
    3. Intracellular LINGO-1 negatively regulates Trk neurotrophin receptor signaling. Meabon JS, et al. Mol Cell Neurosci, 2016 Jan. PMID 26546150, Free PMC Article
    4. Targeted Inhibition of Leucine-Rich Repeat and Immunoglobulin Domain-Containing Protein 1 in Transplanted Neural Stem Cells Promotes Neuronal Differentiation and Functional Recovery in Rats Subjected to Spinal Cord Injury. Chen N, et al. Crit Care Med, 2016 Mar. PMID 26491860
    5. MiR-615 Regulates NSC Differentiation In Vitro and Contributes to Spinal Cord Injury Repair by Targeting LINGO-1. Wu H, et al. Mol Neurobiol, 2020 Jul. PMID 32462552

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MiR-615 Regulates NSC Differentiation In Vitro and Contributes to Spinal Cord Injury Repair by Targeting LINGO-1.
      Title: MiR-615 Regulates NSC Differentiation In Vitro and Contributes to Spinal Cord Injury Repair by Targeting LINGO-1.
    2. LINGO-1 siRNA nanoparticles silencing promoted central remyelination in ethidium bromide-induced demyelination in rats.
      Title: LINGO-1 siRNA nanoparticles promote central remyelination in ethidium bromide-induced demyelination in rats.
    3. in both immature and adult brains, Lingo-1 signaling plays important roles in seizure-induced damage to myelin sheaths and axon growth
      Title: Alterations of Hippocampal Myelin Sheath and Axon Sprouting by Status Convulsion and Regulating Lingo-1 Expression with RNA Interference in Immature and Adult Rats.
    4. Myelin loss and subsequent axon degeneration contributes to a variety of neurological diseases, such as multiple sclerosis (MS).
      Title: LINGO-1 Regulates Oligodendrocyte Differentiation through the Cytoplasmic Gelsolin Signaling Pathway.
    5. We propose that LINGO-1 functions as a negative feedback regulator of signaling by cognate receptor tyrosine kinases including TrkA, TrkB and TrkC.
      Title: Intracellular LINGO-1 negatively regulates Trk neurotrophin receptor signaling.
    6. LINGO-1-RNA interference-treated neural stem cell transplantation increased tissue repair and functional recovery of the injured spinal cord in rats.
      Title: Targeted Inhibition of Leucine-Rich Repeat and Immunoglobulin Domain-Containing Protein 1 in Transplanted Neural Stem Cells Promotes Neuronal Differentiation and Functional Recovery in Rats Subjected to Spinal Cord Injury.
    7. LINGO-1 potentiates neuronal apoptosis, likely by inhibiting WNK3 kinase activity.
      Title: LINGO-1 receptor promotes neuronal apoptosis by inhibiting WNK3 kinase activity.
    8. LINGO-1 inhibits multiple aspects of oligodendrocyte differentiation independently of the LRRs via a process that requires p75(NTR) signalling
      Title: LINGO-1-mediated inhibition of oligodendrocyte differentiation does not require the leucine-rich repeats and is reversed by p75(NTR) antagonists.
    9. Taken together, these results suggest a new mechanism of LINGO-1 antagonist regulated neuronal survival involving protein synthesis of LINGO-1 and inactivation of GSK-3 pathway.
      Title: Inactivation of glycogen synthase kinase-3beta and up-regulation of LINGO-1 are involved in LINGO-1 antagonist regulated survival of cerebellar granular neurons.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables epidermal growth factor receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables epidermal growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within central nervous system neuron development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of oligodendrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of oligodendrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in presynapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
    Names
    leucine rich repeat neuronal 6A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100722.1 → NP_001094192.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 precursor

      See identical proteins and their annotated locations for NP_001094192.1

      Status: VALIDATED

      Source sequence(s)
      BC092632, BE108045, BF547075
      UniProtKB/TrEMBL
      A6J4R0, G3V881
      Conserved Domains (6) summary
      TIGR00864
      Location:341 → 421
      PCC; polycystin cation channel protein
      smart00013
      Location:41 → 75
      LRRNT; Leucine rich repeat N-terminal domain
      COG4886
      Location:66 → 371
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:73 → 96
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:120 → 179
      LRR_8; Leucine rich repeat
      cd20969
      Location:423 → 514
      IgI_Lingo-1; Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      65907275..66089485 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008766270.4 → XP_008764492.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform X1

      See identical proteins and their annotated locations for XP_008764492.1

      UniProtKB/TrEMBL
      A0A8I5ZPI2, A6J4R3
      Related
      ENSRNOP00000110189.1, ENSRNOT00000168236.1
      Conserved Domains (6) summary
      TIGR00864
      Location:335 → 415
      PCC; polycystin cation channel protein
      smart00013
      Location:35 → 69
      LRRNT; Leucine rich repeat N-terminal domain
      COG4886
      Location:60 → 365
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:67 → 90
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:114 → 173
      LRR_8; Leucine rich repeat
      cd20969
      Location:417 → 508
      IgI_Lingo-1; Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1)

    2. XM_017595646.3 → XP_017451135.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZPI2, A6J4R3
      Related
      ENSRNOP00000112140.1, ENSRNOT00000133656.1
      Conserved Domains (6) summary
      TIGR00864
      Location:335 → 415
      PCC; polycystin cation channel protein
      smart00013
      Location:35 → 69
      LRRNT; Leucine rich repeat N-terminal domain
      COG4886
      Location:60 → 365
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:67 → 90
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:114 → 173
      LRR_8; Leucine rich repeat
      cd20969
      Location:417 → 508
      IgI_Lingo-1; Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1)

    3. XM_017595647.3 → XP_017451136.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZPI2, A6J4R3
      Related
      ENSRNOP00000112698.1, ENSRNOT00000162113.1
      Conserved Domains (6) summary
      TIGR00864
      Location:335 → 415
      PCC; polycystin cation channel protein
      smart00013
      Location:35 → 69
      LRRNT; Leucine rich repeat N-terminal domain
      COG4886
      Location:60 → 365
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:67 → 90
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:114 → 173
      LRR_8; Leucine rich repeat
      cd20969
      Location:417 → 508
      IgI_Lingo-1; Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1)

    4. XM_039081468.2 → XP_038937396.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZPI2, A6J4R3
      Conserved Domains (6) summary
      TIGR00864
      Location:335 → 415
      PCC; polycystin cation channel protein
      smart00013
      Location:35 → 69
      LRRNT; Leucine rich repeat N-terminal domain
      COG4886
      Location:60 → 365
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:67 → 90
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:114 → 173
      LRR_8; Leucine rich repeat
      cd20969
      Location:417 → 508
      IgI_Lingo-1; Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1)

    5. XM_063265474.1 → XP_063121544.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZPI2, A6J4R3

    6. XM_039081469.2 → XP_038937397.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZPI2, A6J4R3
      Related
      ENSRNOP00000112849.1, ENSRNOT00000132165.1
      Conserved Domains (6) summary
      TIGR00864
      Location:335 → 415
      PCC; polycystin cation channel protein
      smart00013
      Location:35 → 69
      LRRNT; Leucine rich repeat N-terminal domain
      COG4886
      Location:60 → 365
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:67 → 90
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:114 → 173
      LRR_8; Leucine rich repeat
      cd20969
      Location:417 → 508
      IgI_Lingo-1; Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1)

    7. XM_006243120.5 → XP_006243182.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006243182.1

      UniProtKB/TrEMBL
      A0A8I5ZPI2, A6J4R3
      Related
      ENSRNOP00000097278.1, ENSRNOT00000111614.2
      Conserved Domains (6) summary
      TIGR00864
      Location:335 → 415
      PCC; polycystin cation channel protein
      smart00013
      Location:35 → 69
      LRRNT; Leucine rich repeat N-terminal domain
      COG4886
      Location:60 → 365
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:67 → 90
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:114 → 173
      LRR_8; Leucine rich repeat
      cd20969
      Location:417 → 508
      IgI_Lingo-1; Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1)

    RNA

    1. XR_010053964.1 RNA Sequence

    2. XR_005487818.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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