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    Ess2 ess-2 splicing factor homolog [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360741, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ess2provided by RGD
    Official Full Name
    ess-2 splicing factor homologprovided by RGD
    Primary source
    RGD:1308218
    See related
    EnsemblRapid:ENSRNOG00000000283 AllianceGenome:RGD:1308218
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Dgcr14
    Summary
    Predicted to be involved in mRNA splicing, via spliceosome and nervous system development. Predicted to be located in nucleus. Predicted to be part of catalytic step 2 spliceosome. Orthologous to human ESS2 (ess-2 splicing factor homolog). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 77.4), Spleen (RPKM 53.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ess2 in Genome Data Viewer
    Location:
    11q23
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (96580185..96596673)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (83075893..83085849)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (87224371..87234329)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481037 Neighboring gene uncharacterized LOC134481038 Neighboring gene goosecoid homeobox 2 Neighboring gene testis-specific serine kinase 2 Neighboring gene testis-specific serine kinase 1B Neighboring gene DiGeorge syndrome critical region gene 2 Neighboring gene carbonic anhydrase 15

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. ES2, a gene deleted in DiGeorge syndrome, encodes a nuclear protein and is expressed during early mouse development, where it shares an expression domain with a Goosecoid-like gene. Lindsay EA, et al. Hum Mol Genet, 1998 Apr. PMID 9499415
    2. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. Jurica MS, et al. RNA, 2002 Apr. PMID 11991638, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC109131

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nervous system development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    splicing factor ESS-2 homolog
    Names
    DiGeorge syndrome critical region gene 14 homolog
    DiGeorge syndrome critical region protein 14
    protein DGCR14

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012472.1 → NP_001012490.1  splicing factor ESS-2 homolog

      See identical proteins and their annotated locations for NP_001012490.1

      Status: PROVISIONAL

      Source sequence(s)
      BC089898
      UniProtKB/TrEMBL
      F7ESE9, Q5EB95
      Related
      ENSRNOP00000000308.5, ENSRNOT00000000308.6
      Conserved Domains (1) summary
      pfam09751
      Location:37 → 405
      Es2; Nuclear protein Es2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      96580185..96596673
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006248635.5 → XP_006248697.1  splicing factor ESS-2 homolog isoform X1

      UniProtKB/TrEMBL
      F7ESE9
      Conserved Domains (1) summary
      pfam09751
      Location:37 → 404
      Es2; Nuclear protein Es2

    RNA

    1. XR_005491045.2 RNA Sequence

    2. XR_005491044.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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