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    B3gnt5 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 [ Mus musculus (house mouse) ]

    Gene ID: 108105, updated on 9-Dec-2024

    Summary

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    Official Symbol
    B3gnt5provided by MGI
    Official Full Name
    UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5provided by MGI
    Primary source
    MGI:MGI:2137302
    See related
    Ensembl:ENSMUSG00000022686 AllianceGenome:MGI:2137302
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    beta3GnT5
    Summary
    Predicted to enable N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity and lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity. Predicted to be involved in central nervous system development and protein O-linked glycosylation. Predicted to act upstream of or within sphingolipid biosynthetic process. Predicted to be active in Golgi membrane. Is expressed in several structures, including alimentary system; eye; genitourinary system; hemolymphoid system gland; and nervous system. Orthologous to human B3GNT5 (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in CNS E11.5 (RPKM 4.8), whole brain E14.5 (RPKM 4.4) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See B3gnt5 in Genome Data Viewer
    Location:
    16 A3; 16 12.23 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (19578943..19591508)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (19760192..19772760)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene lysosomal-associated membrane protein 3 Neighboring gene STARR-seq mESC enhancer starr_40303 Neighboring gene STARR-seq mESC enhancer starr_40304 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_40305 Neighboring gene STARR-seq mESC enhancer starr_40307 Neighboring gene RIKEN cDNA A930003A15 gene Neighboring gene STARR-seq mESC enhancer starr_40308 Neighboring gene kelch-like 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Multiple phenotypic changes in mice after knockout of the B3gnt5 gene, encoding Lc3 synthase--a key enzyme in lacto-neolacto ganglioside synthesis. Kuan CT, et al. BMC Dev Biol, 2010 Nov 18. PMID 21087515, Free PMC Article
    2. Lack of lacto/neolacto-glycolipids enhances the formation of glycolipid-enriched microdomains, facilitating B cell activation. Togayachi A, et al. Proc Natl Acad Sci U S A, 2010 Jun 29. PMID 20547865, Free PMC Article
    3. The Lc3-synthase gene B3gnt5 is essential to pre-implantation development of the murine embryo. Biellmann F, et al. BMC Dev Biol, 2008 Nov 12. PMID 19014510, Free PMC Article
    4. Molecular cloning and characterization of UDP-GlcNAc:lactosylceramide beta 1,3-N-acetylglucosaminyltransferase (beta 3Gn-T5), an essential enzyme for the expression of HNK-1 and Lewis X epitopes on glycolipids. Togayachi A, et al. J Biol Chem, 2001 Jun 22. PMID 11283017
    5. Cloning of a mouse beta 1,3 N-acetylglucosaminyltransferase GlcNAc(beta 1,3)Gal(beta 1,4)Glc-ceramide synthase gene encoding the key regulator of lacto-series glycolipid biosynthesis. Henion TR, et al. J Biol Chem, 2001 Aug 10. PMID 11384981

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results demonstrate that Lc3 synthase and lacto-neolacto series gangliosides are essential to multiple physiological functions, especially the control of reproductive output, and spleen B-cell abnormality.
      Title: Multiple phenotypic changes in mice after knockout of the B3gnt5 gene, encoding Lc3 synthase--a key enzyme in lacto-neolacto ganglioside synthesis.
    2. B3gnt5 is essential to pre-implantation development of the murine embryo.
      Title: The Lc3-synthase gene B3gnt5 is essential to pre-implantation development of the murine embryo.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (6)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in central nervous system development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in central nervous system development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein O-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within sphingolipid biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase
    Names
    BGnT-5
    UDP-GlcNAc:beta-Gal beta-1,3-N-acetylglucosaminyltransferase 5
    beta-1,3-Gn-T5
    beta-1,3-N-acetylglucosaminyltransferase 5
    beta3Gn-T5
    lactotriaosylceramide synthase
    lc(3)Cer synthase
    lc3 synthase
    NP_001152879.1
    NP_001152880.1
    NP_473393.2
    XP_006521769.1
    XP_030104776.1
    XP_036015625.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159407.1 → NP_001152879.1  lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase

      See identical proteins and their annotated locations for NP_001152879.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
      Source sequence(s)
      AK037166, AK048010, AK083839, BB667148, BC063076, CN533455
      Consensus CDS
      CCDS28040.1
      UniProtKB/Swiss-Prot
      Q810C6, Q8BGY6, Q923K7
      Related
      ENSMUSP00000126157.2, ENSMUST00000164397.8
      Conserved Domains (1) summary
      cl21608
      Location:101 → 297
      Galactosyl_T; Galactosyltransferase

    2. NM_001159408.1 → NP_001152880.1  lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase

      See identical proteins and their annotated locations for NP_001152880.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      AK037166, AK048010, BB667148, BC063076
      Consensus CDS
      CCDS28040.1
      UniProtKB/Swiss-Prot
      Q810C6, Q8BGY6, Q923K7
      Related
      ENSMUSP00000112624.2, ENSMUST00000121344.8
      Conserved Domains (1) summary
      cl21608
      Location:101 → 297
      Galactosyl_T; Galactosyltransferase

    3. NM_054052.3 → NP_473393.2  lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase

      See identical proteins and their annotated locations for NP_473393.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      AK083839, BB667148, BC063076
      Consensus CDS
      CCDS28040.1
      UniProtKB/Swiss-Prot
      Q810C6, Q8BGY6, Q923K7
      Related
      ENSMUSP00000078712.4, ENSMUST00000079780.10
      Conserved Domains (1) summary
      cl21608
      Location:101 → 297
      Galactosyl_T; Galactosyltransferase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      19578943..19591508
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030248916.2 → XP_030104776.1  lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase isoform X1

      UniProtKB/Swiss-Prot
      Q810C6, Q8BGY6, Q923K7
      Conserved Domains (1) summary
      cl21608
      Location:101 → 297
      Galactosyl_T; Galactosyltransferase

    2. XM_036159732.1 → XP_036015625.1  lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase isoform X1

      UniProtKB/Swiss-Prot
      Q810C6, Q8BGY6, Q923K7
      Conserved Domains (1) summary
      cl21608
      Location:101 → 297
      Galactosyl_T; Galactosyltransferase

    3. XM_006521706.4 → XP_006521769.1  lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase isoform X1

      See identical proteins and their annotated locations for XP_006521769.1

      UniProtKB/Swiss-Prot
      Q810C6, Q8BGY6, Q923K7
      Related
      ENSMUSP00000113145.2, ENSMUST00000119468.2
      Conserved Domains (1) summary
      cl21608
      Location:101 → 297
      Galactosyl_T; Galactosyltransferase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BGY6.1 GenPept UniProtKB/Swiss-Prot:Q8BGY6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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