Nscme3l NSE3 homolog, SMC5-SMC6 complex component like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nscme3lprovided by MGI
Official Full Name: NSE3 homolog, SMC5-SMC6 complex component likeprovided by MGI
Primary source: MGI:MGI:1922805
See related: Ensembl:ENSMUSG00000100937 AllianceGenome:MGI:1922805
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mage-g2; 1700020D05Rik
Summary: Predicted to enable protein dimerization activity. Predicted to be involved in several processes, including cellular response to hydroxyurea; negative regulation of transcription by RNA polymerase II; and positive regulation of protein ubiquitination. Predicted to be part of Smc5-Smc6 complex. Predicted to be active in nucleus. Orthologous to human NSMCE3 (NSE3 homolog, SMC5-SMC6 complex component). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

Location:: 19 A; 19 4.34 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (5552795..5553815, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (5502767..5503787, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Our study suggests that mouse MAGEG2 has at least two functions, including chaperone activity related to HSPA9 and regulation of pachytene spermatocyte-specific kinase, STK31.
Title: Characterization of MAGEG2 with testis-specific expression in mice.

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General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info
enables protein dimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA repair	ISO Inferred from Sequence Orthology more info
involved_in cellular response to UV	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hydroxyurea	ISO Inferred from Sequence Orthology more info
involved_in cellular response to radiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of Smc5-Smc6 complex	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: mage-g2 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.