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    Paqr3 progestin and adipoQ receptor family member III [ Mus musculus (house mouse) ]

    Gene ID: 231474, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Paqr3provided by MGI
    Official Full Name
    progestin and adipoQ receptor family member IIIprovided by MGI
    Primary source
    MGI:MGI:2679683
    See related
    Ensembl:ENSMUSG00000055725 AllianceGenome:MGI:2679683
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RKTG; 6330415A20Rik
    Summary
    Enables ubiquitin-like ligase-substrate adaptor activity. Involved in negative regulation of peroxisome proliferator activated receptor signaling pathway and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Acts upstream of or within negative regulation of MAP kinase activity. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus. Is expressed in cerebral cortex intermediate zone and cortical plate. Orthologous to human PAQR3 (progestin and adipoQ receptor family member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 5.7), whole brain E14.5 (RPKM 5.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Paqr3 in Genome Data Viewer
    Location:
    5 E3; 5 47.29 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (97229223..97259608, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (97081364..97111749, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46916 Neighboring gene STARR-positive B cell enhancer ABC_E11294 Neighboring gene STARR-seq mESC enhancer starr_13683 Neighboring gene STARR-positive B cell enhancer ABC_E1303 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:97425959-97426223 Neighboring gene predicted gene 9484 Neighboring gene BMP2 inducible kinase Neighboring gene STARR-positive B cell enhancer ABC_E3589 Neighboring gene STARR-seq mESC enhancer starr_13685 Neighboring gene STARR-seq mESC enhancer starr_13686 Neighboring gene STARR-positive B cell enhancer mm9_chr5:97540551-97540852 Neighboring gene predicted gene, 33609 Neighboring gene STARR-seq mESC enhancer starr_13687 Neighboring gene predicted gene 2861

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Silencing PAQR3 protects against oxygen-glucose deprivation/reperfusion-induced neuronal apoptosis via activation of PI3K/AKT signaling in PC12 cells. Qiao S, et al. Life Sci, 2021 Jan 15. PMID 33249098
    2. PAQR3 modulates insulin signaling by shunting phosphoinositide 3-kinase p110α to the Golgi apparatus. Wang X, et al. Diabetes, 2013 Feb. PMID 23086038, Free PMC Article
    3. Suppressive function of RKTG on chemical carcinogen-induced skin carcinogenesis in mouse. Xie X, et al. Carcinogenesis, 2008 Aug. PMID 18550569
    4. PAQR3 has modulatory roles in obesity, energy metabolism, and leptin signaling. Wang L, et al. Endocrinology, 2013 Dec. PMID 24035996
    5. Functional cooperation of RKTG with p53 in tumorigenesis and epithelial-mesenchymal transition. Jiang Y, et al. Cancer Res, 2011 Apr 15. PMID 21385899

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Silencing PAQR3 protects against oxygen-glucose deprivation/reperfusion-induced neuronal apoptosis via activation of PI3K/AKT signaling in PC12 cells.
      Title: Silencing PAQR3 protects against oxygen-glucose deprivation/reperfusion-induced neuronal apoptosis via activation of PI3K/AKT signaling in PC12 cells.
    2. PAQR3 plays a pivotal role in controlling hepatic LDLR degradation and blood LDL-C level via modulating LDLR-PCSK9 interaction.
      Title: PAQR3 modulates blood cholesterol level by facilitating interaction between LDLR and PCSK9.
    3. PAQR3 controls autophagy by integrating AMPK signaling to enhance ATG14L-associated PI3K activity
      Title: PAQR3 controls autophagy by integrating AMPK signaling to enhance ATG14L-associated PI3K activity.
    4. PAQR3 regulates cholesterol homeostasis by anchoring Scap/SREBP to the Golgi and disruption of such function reduces cholesterol biosynthesis.
      Title: PAQR3 modulates cholesterol homeostasis by anchoring Scap/SREBP complex to the Golgi apparatus.
    5. This study reveals that PAQR3 has an important physiological function in modulating obesity, energy metabolism, and leptin signaling.
      Title: PAQR3 has modulatory roles in obesity, energy metabolism, and leptin signaling.
    6. PAQR3 negatively regulates insulin signaling by shunting cytosolic p110alpha to the Golgi apparatus while competing with p85 subunit in forming a PI3K complex with p110alpha.
      Title: PAQR3 modulates insulin signaling by shunting phosphoinositide 3-kinase p110α to the Golgi apparatus.
    7. Loss of PAQR3 is associated with tumorigenesis of colorectal cancers.
      Title: PAQR3 plays a suppressive role in the tumorigenesis of colorectal cancers.
    8. reveal a paradigm of spatial regulation of Raf kinase by RKTG via sequestrating Raf-1 to the Golgi apparatus and thereby inhibiting the ERK signaling pathway.
      Title: Spatial regulation of Raf kinase signaling by RKTG.
    9. RKTG has a suppressive activity in chemical carcinogen-induced mitogenesis and tumor formation in mouse skin.
      Title: Suppressive function of RKTG on chemical carcinogen-induced skin carcinogenesis in mouse.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ubiquitin-like ligase-substrate adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of MAP kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in negative regulation of peroxisome proliferator activated receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein localization to Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein localization to Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    progestin and adipoQ receptor family member 3
    Names
    Raf kinase trapping to Golgi

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359910.2 → NP_001346839.1  progestin and adipoQ receptor family member 3 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC125229
      Consensus CDS
      CCDS19451.1
      UniProtKB/Swiss-Prot
      Q6TCG8
      UniProtKB/TrEMBL
      Q0VAZ2, Q3UEZ4
      Related
      ENSMUSP00000108593.4, ENSMUST00000112969.10
      Conserved Domains (1) summary
      pfam03006
      Location:64 → 283
      HlyIII; Haemolysin-III related

    2. NM_001359913.2 → NP_001346842.1  progestin and adipoQ receptor family member 3 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC125229
      Consensus CDS
      CCDS89954.1
      UniProtKB/TrEMBL
      D3Z181
      Related
      ENSMUSP00000108592.2, ENSMUST00000112968.2
      Conserved Domains (1) summary
      cl03831
      Location:64 → 170
      HlyIII; Haemolysin-III related

    3. NM_001428771.1 → NP_001415700.1  progestin and adipoQ receptor family member 3 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC125229
      UniProtKB/Swiss-Prot
      Q6TCG8
      UniProtKB/TrEMBL
      Q0VAZ2, Q3UEZ4

    4. NM_001428772.1 → NP_001415701.1  progestin and adipoQ receptor family member 3 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC125229
      UniProtKB/Swiss-Prot
      Q6TCG8
      UniProtKB/TrEMBL
      Q0VAZ2, Q3UEZ4

    5. NM_001428773.1 → NP_001415702.1  progestin and adipoQ receptor family member 3 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC125229
      UniProtKB/TrEMBL
      Q3UEZ4

    6. NM_001428774.1 → NP_001415703.1  progestin and adipoQ receptor family member 3 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC125229
      UniProtKB/TrEMBL
      Q3UEZ4

    7. NM_001428775.1 → NP_001415704.1  progestin and adipoQ receptor family member 3 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC125229

    8. NM_001428776.1 → NP_001415705.1  progestin and adipoQ receptor family member 3 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC125229

    9. NM_198422.4 → NP_940814.1  progestin and adipoQ receptor family member 3 isoform a

      See identical proteins and their annotated locations for NP_940814.1

      Status: VALIDATED

      Source sequence(s)
      AC125229
      Consensus CDS
      CCDS19451.1
      UniProtKB/Swiss-Prot
      Q6TCG8
      UniProtKB/TrEMBL
      Q0VAZ2, Q3UEZ4
      Related
      ENSMUSP00000069324.3, ENSMUST00000069453.9
      Conserved Domains (1) summary
      pfam03006
      Location:64 → 283
      HlyIII; Haemolysin-III related

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      97229223..97259608 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165068.1 → XP_036020961.1  progestin and adipoQ receptor family member 3 isoform X3

      Conserved Domains (1) summary
      cl03831
      Location:64 → 217
      HlyIII; Haemolysin-III related

    2. XM_006534876.4 → XP_006534939.1  progestin and adipoQ receptor family member 3 isoform X2

      Conserved Domains (1) summary
      cl03831
      Location:64 → 262
      HlyIII; Haemolysin-III related

    3. XM_006534875.5 → XP_006534938.1  progestin and adipoQ receptor family member 3 isoform X1

      Conserved Domains (1) summary
      pfam03006
      Location:64 → 283
      HlyIII; Haemolysin-III related

    4. XM_036165067.1 → XP_036020960.1  progestin and adipoQ receptor family member 3 isoform X2

      Conserved Domains (1) summary
      cl03831
      Location:64 → 262
      HlyIII; Haemolysin-III related
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6TCG8.1 GenPept UniProtKB/Swiss-Prot:Q6TCG8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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