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    Garin2 golgi associated RAB2 interactor 2 [ Mus musculus (house mouse) ]

    Gene ID: 70897, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Garin2provided by MGI
    Official Full Name
    golgi associated RAB2 interactor 2provided by MGI
    Primary source
    MGI:MGI:1918147
    See related
    Ensembl:ENSMUSG00000056987 AllianceGenome:MGI:1918147
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fam71d; GARI-L2; 4921509E07Rik; 4930516C23Rik
    Summary
    Involved in flagellated sperm motility. Acts upstream of or within cell morphogenesis and vacuole organization. Located in sperm midpiece. Is active in sperm head. Orthologous to human GARIN2 (golgi associated RAB2 interactor family member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis adult (RPKM 71.9) See more
    Orthologs
    human all
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    Genomic context

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    See Garin2 in Genome Data Viewer
    Location:
    12 C3; 12 35.51 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (78738257..78781290)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (78691484..78734519)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7151 Neighboring gene coiled-coil domain containing 196 Neighboring gene gephyrin Neighboring gene eukaryotic translation initiation factor 5 pseudogene Neighboring gene STARR-seq mESC enhancer starr_32573 Neighboring gene STARR-seq mESC enhancer starr_32575 Neighboring gene STARR-positive B cell enhancer ABC_E10759 Neighboring gene protein associated with LIN7 1, MAGUK family member Neighboring gene STARR-seq mESC enhancer starr_32577 Neighboring gene STARR-seq mESC enhancer starr_32578 Neighboring gene ATPase, H+ transporting, lysosomal V1 subunit D

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. FAM71D is dispensable for spermatogenesis and male fertility in mice. Mo S, et al. Mol Reprod Dev, 2023 Dec. PMID 37992210
    2. The expression characteristics of FAM71D and its association with sperm motility. Ma Q, et al. Hum Reprod, 2017 Nov 1. PMID 29025071
    3. Golgi associated RAB2 interactor protein family contributes to murine male fertility to various extents by assuring correct morphogenesis of sperm heads. Wang H, et al. PLoS Genet, 2024 Jun. PMID 38935810, Free PMC Article
    4. Large scale screening for novel rab effectors reveals unexpected broad Rab binding specificity. Fukuda M, et al. Mol Cell Proteomics, 2008 Jun. PMID 18256213
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in flagellated sperm motility IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within vacuole organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in sperm head IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in sperm midpiece IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Golgi-associated RAB2 interactor protein 2
    Names
    Golgi associated RAB2 interactor protein 2
    Golgi-associated Rab2B interactor-like 2
    family with sequence similarity 71, member D
    protein FAM71D

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001403949.1 → NP_001390878.1  Golgi-associated RAB2 interactor protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC125057
      UniProtKB/TrEMBL
      Q80W24

    2. NM_001403951.1 → NP_001390880.1  Golgi-associated RAB2 interactor protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC125057
      UniProtKB/TrEMBL
      Q80W24

    3. NM_001403957.1 → NP_001390886.1  Golgi-associated RAB2 interactor protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC125057

    4. NM_001403958.1 → NP_001390887.1  Golgi-associated RAB2 interactor protein 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC125057

    5. NM_001403959.1 → NP_001390888.1  Golgi-associated RAB2 interactor protein 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC125057

    6. NM_001403960.1 → NP_001390889.1  Golgi-associated RAB2 interactor protein 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC125057

    7. NM_001403961.1 → NP_001390890.1  Golgi-associated RAB2 interactor protein 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC125057

    8. NM_001403962.1 → NP_001390891.1  Golgi-associated RAB2 interactor protein 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC125057

    9. NM_001403963.1 → NP_001390892.1  Golgi-associated RAB2 interactor protein 2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC125057

    10. NM_027597.5 → NP_081873.2  Golgi-associated RAB2 interactor protein 2 isoform 2

      See identical proteins and their annotated locations for NP_081873.2

      Status: VALIDATED

      Source sequence(s)
      AC125057
      Consensus CDS
      CCDS88358.1
      UniProtKB/TrEMBL
      Q80W24
      Related
      ENSMUSP00000151845.2, ENSMUST00000219551.2
      Conserved Domains (1) summary
      pfam12480
      Location:114 → 184
      DUF3699; Protein of unknown function (DUF3699)

    11. NM_029069.2 → NP_083345.1  Golgi-associated RAB2 interactor protein 2 isoform 1

      See identical proteins and their annotated locations for NP_083345.1

      Status: VALIDATED

      Source sequence(s)
      AC125057
      Consensus CDS
      CCDS49096.1
      UniProtKB/Swiss-Prot
      D3YV92
      Related
      ENSMUSP00000077119.5, ENSMUST00000077968.5
      Conserved Domains (1) summary
      pfam12480
      Location:114 → 184
      DUF3699; Protein of unknown function (DUF3699)

    RNA

    1. NR_175786.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC125057

    2. NR_175787.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC125057

    3. NR_175788.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC125057

    4. NR_175789.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC125057

    5. NR_175790.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC125057

    6. NR_175791.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC125057

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      78738257..78781290
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157611.1 → XP_036013504.1  Golgi-associated RAB2 interactor protein 2 isoform X6

      Conserved Domains (1) summary
      pfam12480
      Location:18 → 85
      DUF3699; Protein of unknown function (DUF3699)

    2. XM_030246919.2 → XP_030102779.1  Golgi-associated RAB2 interactor protein 2 isoform X8

      Conserved Domains (1) summary
      pfam12480
      Location:20 → 85
      DUF3699; Protein of unknown function (DUF3699)

    3. XM_011244172.2 → XP_011242474.1  Golgi-associated RAB2 interactor protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011242474.1

      UniProtKB/Swiss-Prot
      D3YV92
      Conserved Domains (1) summary
      pfam12480
      Location:114 → 184
      DUF3699; Protein of unknown function (DUF3699)

    4. XM_017315195.2 → XP_017170684.1  Golgi-associated RAB2 interactor protein 2 isoform X1

      UniProtKB/Swiss-Prot
      D3YV92
      Conserved Domains (1) summary
      pfam12480
      Location:114 → 184
      DUF3699; Protein of unknown function (DUF3699)

    5. XM_017315197.2 → XP_017170686.1  Golgi-associated RAB2 interactor protein 2 isoform X2

      Conserved Domains (1) summary
      pfam12480
      Location:114 → 184
      DUF3699; Protein of unknown function (DUF3699)

    6. XM_011244173.2 → XP_011242475.1  Golgi-associated RAB2 interactor protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011242475.1

      UniProtKB/Swiss-Prot
      D3YV92
      Conserved Domains (1) summary
      pfam12480
      Location:114 → 184
      DUF3699; Protein of unknown function (DUF3699)

    7. XM_017315196.2 → XP_017170685.1  Golgi-associated RAB2 interactor protein 2 isoform X1

      UniProtKB/Swiss-Prot
      D3YV92
      Conserved Domains (1) summary
      pfam12480
      Location:114 → 184
      DUF3699; Protein of unknown function (DUF3699)

    8. XM_006516227.3 → XP_006516290.1  Golgi-associated RAB2 interactor protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006516290.1

      UniProtKB/Swiss-Prot
      D3YV92
      Conserved Domains (1) summary
      pfam12480
      Location:114 → 184
      DUF3699; Protein of unknown function (DUF3699)

    9. XM_017315199.2 → XP_017170688.1  Golgi-associated RAB2 interactor protein 2 isoform X4

      Conserved Domains (1) summary
      pfam12480
      Location:114 → 184
      DUF3699; Protein of unknown function (DUF3699)

    RNA

    1. XR_003950085.2 RNA Sequence

    2. XR_001780488.2 RNA Sequence

    3. XR_004937543.1 RNA Sequence

    4. XR_003950084.2 RNA Sequence

    5. XR_001780487.3 RNA Sequence

    6. XR_003950080.2 RNA Sequence

    7. XR_001780485.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3YV92.1 GenPept UniProtKB/Swiss-Prot:D3YV92

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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