Rbp1 retinol binding protein 1, cellular [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rbp1provided by MGI
Official Full Name: retinol binding protein 1, cellularprovided by MGI
Primary source: MGI:MGI:97876
See related: Ensembl:ENSMUSG00000046402 AllianceGenome:MGI:97876
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Crbp; CRBPI; Rbp-1
Summary: Enables all-trans-retinol binding activity. Involved in lipid storage; maintenance of location in cell; and retinoid metabolic process. Acts upstream of or within regulation of granulocyte differentiation; response to vitamin A; and retinoid metabolic process. Located in lipid droplet. Is expressed in several structures, including alimentary system; central nervous system; embryo ectoderm; embryo mesenchyme; and genitourinary system. Human ortholog(s) of this gene implicated in multiple myeloma. Orthologous to human RBP1 (retinol binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in placenta adult (RPKM 52.2), liver E18 (RPKM 35.5) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 E3.3; 9 51.36 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (98305014..98328604)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (98422961..98446551)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CrbpI chaperones retinol and retinal in the cell, protecting them from nonspecific oxidation and delivering them to biosynthesis enzymes where the bound (holo-) and unbound (apo-) forms of CrbpI exert distinct biological functions. Using nanoelectrospray, a native MS assay was developed for probing apo- and holo-CrbpI abundance to facilitate exploring their biological functions in in retinoid metabolism and signaling.
Title: Quantitation of the Noncovalent Cellular Retinol-Binding Protein, Type 1 Complex Through Native Mass Spectrometry.
genetic deletion of RBP1 and RBP2 did not impair synapse ultrastructure of ribbon-type synapses formed between rod bipolar cells (RBCs) and amacrine type-2 (AII) cells in the mouse retina but dramatically reduced the density of presynaptic Ca(2+) channels, decreased and desynchronized evoked neurotransmitter release
Title: Efficient stimulus-secretion coupling at ribbon synapses requires RIM-binding protein tethering of L-type Ca(2+) channels.
RBPs perform unexpectedly broad roles at the active zone that together with those of RIMs are essential for all active zone functions.
Title: How to Make an Active Zone: Unexpected Universal Functional Redundancy between RIMs and RIM-BPs.
RBP1 expression was reduced in tissue and endometrial stromal cells derived from endometritis lesions versus eutopic endometruim in humans and mice.
Title: Retinoic acid biosynthesis is impaired in human and murine endometriosis.
CrbpI loss disrupts all-trans retinoic acid homeostasis in mammary tissue, resulting in microenvironmental defects similar to those observed at the early stages of tumorigenesis.
Title: CrbpI regulates mammary retinoic acid homeostasis and the mammary microenvironment.
glucose homeostasis and energy metabolism rely on Rbp1 expression and its moderation of pancreas retinol and of the autacoid 9-cis-retinoic acid.
Title: CrbpI modulates glucose homeostasis and pancreas 9-cis-retinoic acid concentrations.
As such, the effects of RBP1 on these processes are mediated through both regulation of Runx2 expression and transcriptional activity.
Title: Retinoblastoma binding protein-1 (RBP1) is a Runx2 coactivator and promotes osteoblastic differentiation.
CRBP-I is a cytosolic protein specifically expressed in preadipocytes that regulates adipocyte differentiation in part by affecting PPAR gamma activity.
Title: Cellular retinol-binding protein type I (CRBP-I) regulates adipogenesis.
This murine RBP-null model may have relevance to fetal development in human populations with inadequate retinoid intake.
Title: Increased fibronectin deposition in embryonic hearts of retinol-binding protein-null mice.
Data show that while vitamin A-replete retinol binding protein (rbp)-cryptochrome(cry) 1- and 2-knockout mice are light responsive, vitamin A-depleted knockout mice lose most behavioral and molecular responses to light.
Title: Effect of vitamin A depletion on nonvisual phototransduction pathways in cryptochromeless mice.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D9Mit33 (e-PCR), detects polymorphism
- UniSTS:116782

Rbp1 (e-PCR), detects polymorphism
- UniSTS:526959

Rbp1 (e-PCR), detects polymorphism
- UniSTS:508538

X60367 (e-PCR)
- UniSTS:125818

Rbp1 (e-PCR), detects polymorphism
- UniSTS:186534

Rbp1 (e-PCR), detects polymorphism
- UniSTS:525507

X60367 (e-PCR)
- UniSTS:179956

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables all-trans-retinol binding	IBA Inferred from Biological aspect of Ancestor more info
enables all-trans-retinol binding	IDA Inferred from Direct Assay more info	PubMed
enables all-trans-retinol binding	IGI Inferred from Genetic Interaction more info	PubMed
enables all-trans-retinol binding	ISO Inferred from Sequence Orthology more info
enables all-trans-retinol binding	ISS Inferred from Sequence or Structural Similarity more info
enables fatty acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables retinal binding	IEA Inferred from Electronic Annotation more info
enables retinoid binding	TAS Traceable Author Statement more info	PubMed
enables retinol binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in fatty acid transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipid homeostasis	ISO Inferred from Sequence Orthology more info
involved_in lipid homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in lipid storage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maintenance of location in cell	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of granulocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to benzoic acid	IEA Inferred from Electronic Annotation more info
involved_in response to retinoic acid	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to vitamin A	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retinoic acid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within retinoic acid metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within retinoic acid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retinoid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within retinol metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within retinol metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retinol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in vitamin A metabolic process	ISO Inferred from Sequence Orthology more info
involved_in vitamin A metabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cell body	IEA Inferred from Electronic Annotation more info
located_in cell body	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in lipid droplet	IDA Inferred from Direct Assay more info	PubMed
located_in lipid droplet	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: retinol-binding protein 1

Names: CRBP-I; cellular retinol-binding protein I; mCRBPI

NP_035384.1

EC 2.7.7.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.