Mrs2 MRS2 magnesium transporter [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mrs2provided by MGI
Official Full Name: MRS2 magnesium transporterprovided by MGI
Primary source: MGI:MGI:2685748
See related: Ensembl:ENSMUSG00000021339 AllianceGenome:MGI:2685748
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: HPT; RPT; Gm902; Mrs2l
Summary: Predicted to enable magnesium ion transmembrane transporter activity. Predicted to be involved in lactate metabolic process and mitochondrial magnesium ion transmembrane transport. Located in mitochondrion. Orthologous to human MRS2 (magnesium transporter MRS2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in cerebellum adult (RPKM 14.1), colon adult (RPKM 13.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 A3.1; 13 10.83 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (25171466..25204345, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (24987483..25020363, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mice Lacking Mrs2 Magnesium Transporter are Hypophagic and Thin When Maintained on a High-Fat Diet.
Title: Mice Lacking Mrs2 Magnesium Transporter are Hypophagic and Thin When Maintained on a High-Fat Diet.
Limiting Mrs2-dependent mitochondrial Mg[2+] uptake induces metabolic programming in prolonged dietary stress.
Title: Limiting Mrs2-dependent mitochondrial Mg(2+) uptake induces metabolic programming in prolonged dietary stress.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables magnesium ion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables magnesium ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables magnesium ion transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in lactate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in lactate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial magnesium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial magnesium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial magnesium ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: magnesium transporter MRS2 homolog, mitochondrial

Names: MRS2 magnesium homeostasis factor homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013389.2 → NP_001013407.2 magnesium transporter MRS2 homolog, mitochondrial precursor

See identical proteins and their annotated locations for NP_001013407.2

Status: VALIDATED

Source sequence(s)

AL645533, AW456688, BB015377, BU058305, CA752560

Consensus CDS

CCDS26385.2

UniProtKB/Swiss-Prot

Q5NCE8

Related

ENSMUSP00000021772.4, ENSMUST00000021772.4

Conserved Domains (1) summary

cd12823
Location:79 → 390

Mrs2_Mfm1p-like; Saccharomyces cerevisiae inner mitochondrial membrane Mg2+ transporters Mfm1p and Mrs2p-like family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

25171466..25204345 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006516707.5 → XP_006516770.2 magnesium transporter MRS2 homolog, mitochondrial isoform X1

Conserved Domains (1) summary

cd12823
Location:79 → 351

Mrs2_Mfm1p-like; Saccharomyces cerevisiae inner mitochondrial membrane Mg2+ transporters Mfm1p and Mrs2p-like family