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    Ino80e INO80 complex subunit E [ Mus musculus (house mouse) ]

    Gene ID: 233875, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ino80eprovided by MGI
    Official Full Name
    INO80 complex subunit Eprovided by MGI
    Primary source
    MGI:MGI:2141881
    See related
    Ensembl:ENSMUSG00000030689 AllianceGenome:MGI:2141881
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ccdc85; Ccdc95
    Summary
    Predicted to be involved in several processes, including chromatin remodeling; regulation of chromosome organization; and regulation of nucleobase-containing compound metabolic process. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of Ino80 complex. Is expressed in cerebral cortex ventricular layer and cortical plate. Orthologous to human INO80E (INO80 complex subunit E). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 20.5), ovary adult (RPKM 17.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ino80e in Genome Data Viewer
    Location:
    7 F3; 7 69.25 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (126450756..126461544, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (126851584..126862372, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene TLC domain containing 3B Neighboring gene RIKEN cDNA 4930451I11 gene Neighboring gene double C2, alpha Neighboring gene STARR-positive B cell enhancer ABC_E8843 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134005673-134005856 Neighboring gene HIRA interacting protein 3 Neighboring gene TAO kinase 2 Neighboring gene STARR-positive B cell enhancer ABC_E2849 Neighboring gene transmembrane protein 219 Neighboring gene predicted gene, 23445

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The mINO80 chromatin remodeling complex is required for efficient telomere replication and maintenance of genome stability. Min JN, et al. Cell Res, 2013 Dec. PMID 23979016, Free PMC Article
    2. The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1. Elsen GE, et al. Front Neurosci, 2018. PMID 30186101, Free PMC Article
    3. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Rudra D, et al. Nat Immunol, 2012 Oct. PMID 22922362, Free PMC Article
    4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    5. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC31515

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA strand elongation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of chromosome organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Ino80 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Ino80 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    INO80 complex subunit E
    Names
    NO80 complex subunit E
    coiled-coil domain containing 95

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001370765.1 → NP_001357694.1  INO80 complex subunit E isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC124505
      Related
      ENSMUST00000125624.8

    2. NM_153580.1 → NP_705808.1  INO80 complex subunit E isoform 2

      Status: VALIDATED

      Source sequence(s)
      BC026475
      Consensus CDS
      CCDS21848.1
      UniProtKB/TrEMBL
      Q8R359
      Related
      ENSMUSP00000049851.8, ENSMUST00000050833.14

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      126450756..126461544 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507733.4 → XP_006507796.1  INO80 complex subunit E isoform X7

    2. XM_036153016.1 → XP_036008909.1  INO80 complex subunit E isoform X6

    3. XM_011241778.3 → XP_011240080.1  INO80 complex subunit E isoform X5

      Conserved Domains (1) summary
      pfam08537
      Location:77 → 161
      NBP1; Fungal Nap binding protein NBP1

    4. XM_006507731.1 → XP_006507794.1  INO80 complex subunit E isoform X2

      UniProtKB/TrEMBL
      A0A0U1RP99
      Related
      ENSMUSP00000145893.2, ENSMUST00000206968.2
      Conserved Domains (1) summary
      pfam08537
      Location:77 → 161
      NBP1; Fungal Nap binding protein NBP1

    5. XM_006507730.1 → XP_006507793.1  INO80 complex subunit E isoform X1

      UniProtKB/TrEMBL
      A0A0U1RP99

    6. XM_011241777.3 → XP_011240079.1  INO80 complex subunit E isoform X4

      UniProtKB/TrEMBL
      A0A0U1RP99

    7. XM_006507732.3 → XP_006507795.1  INO80 complex subunit E isoform X3

    RNA

    1. XR_378240.4 RNA Sequence

      Related
      ENSMUST00000106343.3

    2. XR_003946467.1 RNA Sequence

    3. XR_003946466.1 RNA Sequence

    4. XR_378241.5 RNA Sequence

    5. XR_378239.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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