Nmi N-myc (and STAT) interactor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nmiprovided by MGI
Official Full Name: N-myc (and STAT) interactorprovided by MGI
Primary source: MGI:MGI:1928368
See related: Ensembl:ENSMUSG00000026946 AllianceGenome:MGI:1928368
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable identical protein binding activity. Involved in positive regulation of inflammatory response; response to virus; and toll-like receptor 4 signaling pathway. Acts upstream of or within negative regulation of innate immune response; negative regulation of type I interferon production; and positive regulation of protein K48-linked ubiquitination. Located in extracellular space. Is expressed in genitourinary system; limb; and retina. Orthologous to human NMI (N-myc and STAT interactor). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in bladder adult (RPKM 5.8), large intestine adult (RPKM 5.4) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 C1.1; 2 29.98 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (51838517..51863241, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (51948498..51973489, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

N-Myc and STAT Interactor is an Endometriosis Suppressor.
Title: N-Myc and STAT Interactor is an Endometriosis Suppressor.
NMI promotes tumor progression and gemcitabine resistance in pancreatic cancer via STAT3-IFIT3 axis.
Title: NMI promotes tumor progression and gemcitabine resistance in pancreatic cancer via STAT3-IFIT3 axis.
IFP35 family proteins promote neuroinflammation and multiple sclerosis.
Title: IFP35 family proteins promote neuroinflammation and multiple sclerosis.
NMI Facilitates Influenza A Virus Infection by Promoting Degradation of IRF7 through TRIM21.
Title: NMI Facilitates Influenza A Virus Infection by Promoting Degradation of IRF7 through TRIM21.
Nmi has a distinct role in the differentiation process of mammary luminal epithelial cell compartment and developmental aberrations resulting from Nmi absence contribute to metastasis.
Title: Conditional knockout of N-Myc and STAT interactor disrupts normal mammary development and enhances metastatic ability of mammary tumors.
Damage-associated molecular patterns (DAMP) are important mediators of innate immunity. Here the authors show that N-myc and STAT interactor (NMI) and interferon-induced protein 35 (IFP35) act as DAMPs to promote inflammation by activating macrophages via the Toll-like receptor 4 and NF-kappaB pathways.
Title: NMI and IFP35 serve as proinflammatory DAMPs during cellular infection and injury.
These findings suggest that Nmi is a negative regulator of the virus-triggered induction of type I IFNs that targets IRF7
Title: Negative regulation of Nmi on virus-triggered type I IFN production by targeting IRF7.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in macrophage activation involved in immune response	ISO Inferred from Sequence Orthology more info
involved_in macrophage activation involved in immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of innate immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of innate immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of interferon-alpha production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of interferon-beta production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of non-canonical NF-kappaB signal transduction	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of type I interferon production	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of non-canonical NF-kappaB signal transduction	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of protein K48-linked ubiquitination	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of protein K48-linked ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in toll-like receptor 4 signaling pathway	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: N-myc-interactor

Names: N-mcy (and STAT) interactor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001141948.2 → NP_001135420.1 N-myc-interactor isoform a

See identical proteins and their annotated locations for NP_001135420.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 4. Variants 1-4 all encode the same isoform (a).

Source sequence(s)

AL929026

Consensus CDS

CCDS16031.1

UniProtKB/Swiss-Prot

O35309, Q99M49

UniProtKB/TrEMBL

Q3UJ82, Q4FJP2

Related

ENSMUSP00000108325.3, ENSMUST00000112705.9

Conserved Domains (2) summary

pfam07334
Location:30 → 105

IFP_35_N; Interferon-induced 35 kDa protein (IFP 35) N-terminus

pfam07292
Location:204 → 292

NID; Nmi/IFP 35 domain (NID)
NM_001141949.2 → NP_001135421.1 N-myc-interactor isoform a

See identical proteins and their annotated locations for NP_001135421.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 4. Variants 1-4 all encode the same isoform (a).

Source sequence(s)

AL929026

Consensus CDS

CCDS16031.1

UniProtKB/Swiss-Prot

O35309, Q99M49

UniProtKB/TrEMBL

Q3UJ82, Q4FJP2

Related

ENSMUSP00000120647.2, ENSMUST00000145481.8

Conserved Domains (2) summary

pfam07334
Location:30 → 105

IFP_35_N; Interferon-induced 35 kDa protein (IFP 35) N-terminus

pfam07292
Location:204 → 292

NID; Nmi/IFP 35 domain (NID)
NM_001421887.1 → NP_001408816.1 N-myc-interactor isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (a). Variants 1-4 all encode the same isoform (a).

Source sequence(s)

AL929026

UniProtKB/Swiss-Prot

O35309, Q99M49

UniProtKB/TrEMBL

Q3UJ82, Q4FJP2
NM_001421888.1 → NP_001408817.1 N-myc-interactor isoform b

Status: VALIDATED

Source sequence(s)

AL929026

UniProtKB/TrEMBL

Q4FJP2
NM_001421889.1 → NP_001408818.1 N-myc-interactor isoform c

Status: VALIDATED

Source sequence(s)

AL929026
NM_001421890.1 → NP_001408819.1 N-myc-interactor isoform c

Status: VALIDATED

Source sequence(s)

AL929026
NM_001421891.1 → NP_001408820.1 N-myc-interactor isoform c

Status: VALIDATED

Source sequence(s)

AL929026
NM_019401.3 → NP_062274.1 N-myc-interactor isoform a

See identical proteins and their annotated locations for NP_062274.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 4. Variants 1-4 all encode the same isoform (a).

Source sequence(s)

AL929026

Consensus CDS

CCDS16031.1

UniProtKB/Swiss-Prot

O35309, Q99M49

UniProtKB/TrEMBL

Q3UJ82, Q4FJP2

Related

ENSMUSP00000028314.3, ENSMUST00000028314.9

Conserved Domains (2) summary

pfam07334
Location:30 → 105

IFP_35_N; Interferon-induced 35 kDa protein (IFP 35) N-terminus

pfam07292
Location:204 → 292

NID; Nmi/IFP 35 domain (NID)