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    H2az2 H2A.Z histone variant 2 [ Mus musculus (house mouse) ]

    Gene ID: 77605, updated on 17-Dec-2024

    Summary

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    Official Symbol
    H2az2provided by MGI
    Official Full Name
    H2A.Z histone variant 2provided by MGI
    Primary source
    MGI:MGI:1924855
    See related
    Ensembl:ENSMUSG00000041126 AllianceGenome:MGI:1924855
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    H2av; H2afv; H2A.Z2; H2a.z-2; Wnt1cre; Wnt1-Cre; Wnt1::Cre; C530002L11Rik; Tg(Wnt1-cre)11Rth
    Summary
    Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. [provided by RefSeq, Nov 2015]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 129.3), CNS E14 (RPKM 78.5) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See H2az2 in Genome Data Viewer
    Location:
    11 A1; 11 4.01 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (6377226..6394511, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (6427226..6444511, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene zinc finger, MIZ-type containing 2 Neighboring gene microRNA 7651 Neighboring gene STARR-seq mESC enhancer starr_28463 Neighboring gene STARR-positive B cell enhancer ABC_E5206 Neighboring gene peptidylprolyl isomerase A Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:6344510-6344697 Neighboring gene 60S ribosomal protein L36a-like Neighboring gene predicted gene 11971

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Divergent fate and origin of neurosphere-like bodies from different layers of the gut. Becker L, et al. Am J Physiol Gastrointest Liver Physiol, 2012 May 1. PMID 22361728, Free PMC Article
    2. Neural crest-derived stem cells migrate and differentiate into cardiomyocytes after myocardial infarction. Tamura Y, et al. Arterioscler Thromb Vasc Biol, 2011 Mar. PMID 21212399
    3. Sox10-Venus mice: a new tool for real-time labeling of neural crest lineage cells and oligodendrocytes. Shibata S, et al. Mol Brain, 2010 Oct 31. PMID 21034515, Free PMC Article
    4. Skin-Derived Precursors as a Source of Progenitors for Corneal Endothelial Regeneration. Inagaki E, et al. Stem Cells Transl Med, 2017 Mar. PMID 28186681, Free PMC Article
    5. The adult mouse and human pancreas contain rare multipotent stem cells that express insulin. Smukler SR, et al. Cell Stem Cell, 2011 Mar 4. PMID 21362568

    See all (867) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification of Potential Biomarkers of Type 2 Diabetes Mellitus-Related Immune Infiltration Using Weighted Gene Coexpression Network Analysis.
      Title: Identification of Potential Biomarkers of Type 2 Diabetes Mellitus-Related Immune Infiltration Using Weighted Gene Coexpression Network Analysis.
    2. Histone H2A.Z is required for androgen receptor-mediated effects on fear memory.
      Title: Histone H2A.Z is required for androgen receptor-mediated effects on fear memory.
    3. Histone variant dictates fate biasing of neural crest cells to melanocyte lineage.
      Title: Histone variant dictates fate biasing of neural crest cells to melanocyte lineage.
    4. Histone variant H2A.Z regulates nucleosome unwrapping and CTCF binding in mouse ES cells.
      Title: Histone variant H2A.Z regulates nucleosome unwrapping and CTCF binding in mouse ES cells.
    5. H2A.Z is dispensable for both basal and activated transcription in post-mitotic mouse muscles.
      Title: H2A.Z is dispensable for both basal and activated transcription in post-mitotic mouse muscles.
    6. H2A.Z.2 expression is closely associated with microglia embryonic development. A key role of H2A.Z.2 in neural progenitor cells in controlling microglial development.H2A.Z.2- and G9a-mediated H3K9me2 modifications regulate Cxcl14 transcription in microglial embryonic development.
      Title: Neural progenitor cells mediated by H2A.Z.2 regulate microglial development via Cxcl14 in the embryonic brain.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of chromatin IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin organization NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of nucleosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nucleosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    histone H2A.V
    Names
    H2A histone family, member V
    H2A.Z variant histone 2
    histone H2A.F/Z

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347064.1 → NP_001333993.1  histone H2A.V isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 2, which lacks an internal in-frame segment and is shorter, compared to isoform 1.
      Source sequence(s)
      AI851486, AL646020, BC028539, CJ069840
      Consensus CDS
      CCDS83779.1
      UniProtKB/TrEMBL
      Q5NC91, Q8R029
      Related
      ENSMUSP00000091037.6, ENSMUST00000093346.6
      Conserved Domains (1) summary
      PTZ00017
      Location:3 → 90
      PTZ00017; histone H2A; Provisional

    2. NM_029938.1 → NP_084214.1  histone H2A.V isoform 1

      See identical proteins and their annotated locations for NP_084214.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AL646020, BC147294, CJ069840
      Consensus CDS
      CCDS48750.1
      UniProtKB/Swiss-Prot
      Q3THW5, Q5NC92, Q6ZWU0
      UniProtKB/TrEMBL
      B2RVP5
      Related
      ENSMUSP00000105359.3, ENSMUST00000109737.9
      Conserved Domains (1) summary
      PLN00154
      Location:6 → 121
      PLN00154; histone H2A; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      6377226..6394511 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030246426.2 → XP_030102286.1  histone H2A.V isoform X1

      Conserved Domains (1) summary
      PLN00154
      Location:30 → 124
      PLN00154; histone H2A; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3THW5.3 GenPept UniProtKB/Swiss-Prot:Q3THW5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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