Zrsr2-ps1 zinc finger (CCCH type), RNA binding motif and serine/arginine rich 2, pseudogene 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zrsr2-ps1provided by MGI
Official Full Name: zinc finger (CCCH type), RNA binding motif and serine/arginine rich 2, pseudogene 1provided by MGI
Primary source: MGI:MGI:98885
See related: AllianceGenome:MGI:98885
Gene type: pseudo
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SP2; Zrsr1; Irlgs2; D11Ncvs75; U2af1-rs1; U2afbp-rs
Summary: Predicted to enable identical protein binding activity and pre-mRNA 3'-splice site binding activity. Involved in mRNA splicing, via spliceosome. Part of U12-type spliceosomal complex. Is expressed in several structures, including early conceptus; liver; nervous system; reproductive system; and sensory organ. Human ortholog(s) of this gene implicated in acute myeloid leukemia and myelodysplastic syndrome. Orthologous to human ZRSR2P1 (ZRSR2 pseudogene 1) and ZRSR2 (zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

Location:: 11 A3.2; 11 14.24 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (22922019..22926500)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (22972005..22976496)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ZRSR1 co-operates with ZRSR2 in regulating splicing of U12-type introns in murine hematopoietic cells.
Title: ZRSR1 co-operates with ZRSR2 in regulating splicing of U12-type introns in murine hematopoietic cells.
Minor Splicing Factors Zrsr1 and Zrsr2 Are Essential for Early Embryo Development and 2-Cell-Like Conversion.
Title: Minor Splicing Factors Zrsr1 and Zrsr2 Are Essential for Early Embryo Development and 2-Cell-Like Conversion.
these results suggest that Zrsr1 expression and function are relevant to organization of the hypothalamic cell network controlling behavior.
Title: Sex-Dimorphic Behavioral Alterations and Altered Neurogenesis in U12 Intron Splicing-Defective Zrsr1 Mutant Mice.
ZRSR1 splicing-defective mutation impairs spermatogenesis, muscle and erythrocytes function.
Title: Impaired Spermatogenesis, Muscle, and Erythrocyte Function in U12 Intron Splicing-Defective Zrsr1 Mutant Mice.
Results indicate that the establishment of methylation at Zrsr1-DMR occurs in a transcription-dependent and oocyte-specific manner and caused Zrsr1 imprinting by repressing maternal expression.
Title: Growing oocyte-specific transcription-dependent de novo DNA methylation at the imprinted Zrsr1-DMR.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Targeted (1) 1 citation

General gene information

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Markers

Murr1 (e-PCR), detects polymorphism
- UniSTS:143935

Murr1 (e-PCR), detects polymorphism
- UniSTS:143936

Zrsr1 (e-PCR), detects polymorphism
- UniSTS:479299

U2af1-rs1 (e-PCR), detects polymorphism
- UniSTS:144716

PMC303337P1 (e-PCR)
- UniSTS:272493

PMC303337P2 (e-PCR)
- UniSTS:272494

PMC303337P4 (e-PCR)
- UniSTS:272496

Zrsr1 (e-PCR), detects polymorphism
- UniSTS:277884

RH137461 (e-PCR)
- UniSTS:219549

PMC87265P1 (e-PCR)
- UniSTS:273589

PMC87265P2 (e-PCR)
- UniSTS:273590

Zrsr1 (e-PCR), detects polymorphism
- UniSTS:532163

Zrsr1 (e-PCR), detects polymorphism
- UniSTS:548091

Other Names

CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 1
U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 1, related sequence 1
U2 small nuclear ribonucleoprotein auxiliary factor (U2AF), 35 kDa, related sequence 1
U2 small nuclear ribonucleoprotein auxiliary factor (U2AF), related sequence 1
U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1
U2(RNU2) small nuclear RNA auxiliary factor 1-like 1
zinc finger (CCCH type), RNA binding motif and serine/arginine rich 1

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables pre-mRNA 3'-splice site binding	IBA Inferred from Biological aspect of Ancestor more info
enables pre-mRNA 3'-splice site binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA splicing, via spliceosome	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of U12-type spliceosomal complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of U12-type spliceosomal complex	ISO Inferred from Sequence Orthology more info
part_of U2AF complex	IBA Inferred from Biological aspect of Ancestor more info
part_of U2AF complex	IEA Inferred from Electronic Annotation more info
part_of spliceosomal complex	IBA Inferred from Biological aspect of Ancestor more info
part_of spliceosomal complex	IMP Inferred from Mutant Phenotype more info	PubMed

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.