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    Cnksr1 connector enhancer of kinase suppressor of Ras 1 [ Mus musculus (house mouse) ]

    Gene ID: 194231, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cnksr1provided by MGI
    Official Full Name
    connector enhancer of kinase suppressor of Ras 1provided by MGI
    Primary source
    MGI:MGI:2670958
    See related
    Ensembl:ENSMUSG00000028841 AllianceGenome:MGI:2670958
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable protein-macromolecule adaptor activity. Predicted to act upstream of or within Ras protein signal transduction and Rho protein signal transduction. Predicted to be located in cell cortex. Orthologous to human CNKSR1 (connector enhancer of kinase suppressor of Ras 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in large intestine adult (RPKM 14.7), colon adult (RPKM 13.4) and 14 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cnksr1 in Genome Data Viewer
    Location:
    4 D2.3; 4 66.5 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (133955352..133965737, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (134228041..134238416, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene zona pellucida like domain containing 2 Neighboring gene cation channel, sperm associated 4 Neighboring gene STARR-positive B cell enhancer ABC_E7997 Neighboring gene Zfp593 opposite strand Neighboring gene zinc finger protein 593 Neighboring gene predicted gene, 30191

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Ras protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within Rho protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell cortex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    connector enhancer of kinase suppressor of ras 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081047.1 → NP_001074516.1  connector enhancer of kinase suppressor of ras 1

      Status: PROVISIONAL

      Source sequence(s)
      AL627314
      Consensus CDS
      CCDS38912.1
      UniProtKB/TrEMBL
      A2A9K7, Q14CF7
      Related
      ENSMUSP00000030645.9, ENSMUST00000030645.9
      Conserved Domains (6) summary
      smart00454
      Location:4 → 69
      SAM; Sterile alpha motif
      cd00992
      Location:205 → 273
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01260
      Location:376 → 489
      PH_CNK_mammalian-like; Connector enhancer of KSR (Kinase suppressor of ras) (CNK) pleckstrin homology (PH) domain
      pfam00169
      Location:390 → 486
      PH; PH domain
      pfam10534
      Location:78 → 162
      CRIC_ras_sig; Connector enhancer of kinase suppressor of ras
      cl15755
      Location:4 → 70
      SAM_superfamily; SAM (Sterile alpha motif )

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      133955352..133965737 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011250217.1 → XP_011248519.1  connector enhancer of kinase suppressor of ras 1 isoform X1

      Conserved Domains (1) summary
      cd01260
      Location:75 → 188
      PH_CNK_mammalian-like; Connector enhancer of KSR (Kinase suppressor of ras) (CNK) pleckstrin homology (PH) domain

    2. XM_011250218.4 → XP_011248520.1  connector enhancer of kinase suppressor of ras 1 isoform X2

      Conserved Domains (3) summary
      cd00992
      Location:205 → 273
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam10534
      Location:78 → 162
      CRIC_ras_sig; Connector enhancer of kinase suppressor of ras
      cl15755
      Location:4 → 70
      SAM_superfamily; SAM (Sterile alpha motif )
    Nucleotide Protein Strain
    Heading Accession and Version

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