Atp2a2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Atp2a2provided by MGI
Official Full Name: ATPase, Ca++ transporting, cardiac muscle, slow twitch 2provided by MGI
Primary source: MGI:MGI:88110
See related: Ensembl:ENSMUSG00000029467 AllianceGenome:MGI:88110
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SERCA2; SERCA2B; Serca2a; D5Wsu150e; mKIAA4195; 9530097L16Rik
Summary: Enables P-type calcium transporter activity; enzyme binding activity; and lncRNA binding activity. Involved in calcium ion import into sarcoplasmic reticulum and calcium ion transmembrane transport. Acts upstream of or within several processes, including T-tubule organization; cardiac muscle hypertrophy in response to stress; and regulation of heart contraction. Located in membrane; ribbon synapse; and sarcoplasmic reticulum. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Used to study keratosis follicularis. Human ortholog(s) of this gene implicated in acrokeratosis verruciformis; essential hypertension; keratosis follicularis; and pulmonary hypertension. Orthologous to human ATP2A2 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in heart adult (RPKM 1140.8), bladder adult (RPKM 124.3) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 62.38 cM; 5 F

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (122591576..122640288, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (122453513..122502225, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deubiquitinase JOSD2 improves calcium handling and attenuates cardiac hypertrophy and dysfunction by stabilizing SERCA2a in cardiomyocytes.
Title: Deubiquitinase JOSD2 improves calcium handling and attenuates cardiac hypertrophy and dysfunction by stabilizing SERCA2a in cardiomyocytes.
Perimenopause Decreases SERCA2a Activity in the Hearts of a Mouse Model of Ovarian Failure.
Title: Perimenopause Decreases SERCA2a Activity in the Hearts of a Mouse Model of Ovarian Failure.
Involvement of nucleus accumbens SERCA2b in methamphetamine-induced conditioned place preference.
Title: Involvement of nucleus accumbens SERCA2b in methamphetamine-induced conditioned place preference.
Remodelling of cAMP dynamics within the SERCA2a microdomain in heart failure with preserved ejection fraction caused by obesity and type 2 diabetes.
Title: Remodelling of cAMP dynamics within the SERCA2a microdomain in heart failure with preserved ejection fraction caused by obesity and type 2 diabetes.
FBXL4 protects against HFpEF through Drp1-Mediated regulation of mitochondrial dynamics and the downstream SERCA2a.
Title: FBXL4 protects against HFpEF through Drp1-Mediated regulation of mitochondrial dynamics and the downstream SERCA2a.
Early consequences of the phospholamban mutation PLN-R14del[+/-] in a transgenic mouse model.
Title: Early consequences of the phospholamban mutation PLN-R14del(+/-) in a transgenic mouse model.
ZBTB20 Regulates SERCA2a Activity and Myocardial Contractility Through Phospholamban.
Title: ZBTB20 Regulates SERCA2a Activity and Myocardial Contractility Through Phospholamban.
Rescuing SERCA2 pump deficiency improves bone mechano-responsiveness in type 2 diabetes by shaping osteocyte calcium dynamics.
Title: Rescuing SERCA2 pump deficiency improves bone mechano-responsiveness in type 2 diabetes by shaping osteocyte calcium dynamics.
SERCA2 dysfunction triggers hypertension by interrupting mitochondrial homeostasis and provoking oxidative stress.
Title: SERCA2 dysfunction triggers hypertension by interrupting mitochondrial homeostasis and provoking oxidative stress.
Mettl13 protects against cardiac contractile dysfunction by negatively regulating C-Cbl-mediated ubiquitination of SERCA2a in ischemic heart failure.
Title: Mettl13 protects against cardiac contractile dysfunction by negatively regulating C-Cbl-mediated ubiquitination of SERCA2a in ischemic heart failure.

Submit: New GeneRIF Correction See all GeneRIFs (128)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)
Targeted (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:235302

D11Bhm20 (e-PCR), detects polymorphism
- UniSTS:141619

D9Mit34.1 (e-PCR), detects polymorphism
- UniSTS:131903

NoName (e-PCR)
- UniSTS:224630

G15902 (e-PCR)
- UniSTS:4216

ATP2A2__4219 (e-PCR)
- UniSTS:462756

RH124668 (e-PCR)
- UniSTS:161490

RH125765 (e-PCR)
- UniSTS:142568

D12S2026 (e-PCR)
- UniSTS:21224

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables P-type calcium transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables P-type calcium transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables P-type calcium transporter activity	ISO Inferred from Sequence Orthology more info
enables P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential	IBA Inferred from Biological aspect of Ancestor more info
enables P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential	ISO Inferred from Sequence Orthology more info
enables P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential	ISS Inferred from Sequence or Structural Similarity more info
enables S100 protein binding	IEA Inferred from Electronic Annotation more info
enables S100 protein binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables lncRNA binding	IPI Inferred from Physical Interaction more info	PubMed
enables lutropin-choriogonadotropic hormone receptor binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane transporter binding	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within ER-nucleus signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within T-tubule organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagosome assembly	ISO Inferred from Sequence Orthology more info
involved_in autophagosome assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in autophagosome membrane docking	ISO Inferred from Sequence Orthology more info
involved_in autophagosome membrane docking	ISS Inferred from Sequence or Structural Similarity more info
involved_in calcium ion import into sarcoplasmic reticulum	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion import into sarcoplasmic reticulum	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transport from cytosol to endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transport from cytosol to endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cardiac muscle hypertrophy in response to stress	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to oxidative stress	IGI Inferred from Genetic Interaction more info	PubMed
involved_in endoplasmic reticulum calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular calcium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intracellular calcium ion homeostasis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within intracellular calcium ion homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within intracellular calcium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in mitochondrion-endoplasmic reticulum membrane tethering	ISO Inferred from Sequence Orthology more info
involved_in mitochondrion-endoplasmic reticulum membrane tethering	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of heart contraction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of receptor binding	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron cellular homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neuron cellular homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in organelle localization by membrane tethering	ISO Inferred from Sequence Orthology more info
involved_in organelle localization by membrane tethering	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within organelle organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cardiac muscle cell apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of endoplasmic reticulum calcium ion concentration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of endoplasmic reticulum calcium ion concentration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of calcium ion-dependent exocytosis of neurotransmitter	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cardiac muscle cell action potential involved in regulation of contraction	ISO Inferred from Sequence Orthology more info
involved_in regulation of cardiac muscle cell membrane potential	IEA Inferred from Electronic Annotation more info
involved_in regulation of cardiac muscle cell membrane potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of cardiac muscle contraction by calcium ion signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cardiac muscle contraction by calcium ion signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of muscle contraction	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within regulation of the force of heart contraction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in relaxation of cardiac muscle	ISO Inferred from Sequence Orthology more info
involved_in response to peptide hormone	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sarcoplasmic reticulum calcium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sarcoplasmic reticulum calcium ion transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within transition between fast and slow fiber	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in apical ectoplasmic specialization	ISO Inferred from Sequence Orthology more info
part_of calcium ion-transporting ATPase complex	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info	PubMed
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in extrinsic component of cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info
colocalizes_with intercalated disc	ISO Inferred from Sequence Orthology more info
located_in longitudinal sarcoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info	PubMed
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane bounded cell projection	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in ribbon synapse	IDA Inferred from Direct Assay more info	PubMed
located_in sarcoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in sarcoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in sarcoplasmic reticulum	TAS Traceable Author Statement more info	PubMed
located_in sarcoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in sarcoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sarcoplasmic/endoplasmic reticulum calcium ATPase 2

Names: SR Ca(2+)-ATPase 2; calcium pump 2; endoplasmic reticulum class 1/2 Ca(2+) ATPase; sarco/endoplasmic reticulum Ca2+-ATPase 2

NP_001103610.1

EC 7.2.2.10

NP_033852.1

EC 7.2.2.10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001110140.3 → NP_001103610.1 sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform b

See identical proteins and their annotated locations for NP_001103610.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (b), also known as SERCA2B.

Source sequence(s)

AJ131821, AK220538, CF742600, CJ162528

Consensus CDS

CCDS57378.1

UniProtKB/Swiss-Prot

O55143, Q9R2A9, Q9WUT5

UniProtKB/TrEMBL

Q5DTI2

Related

ENSMUSP00000031423.9, ENSMUST00000031423.10

Conserved Domains (6) summary

TIGR01116
Location:53 → 988

ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase

pfam00122
Location:93 → 340

E1-E2_ATPase; E1-E2 ATPase

pfam00689
Location:783 → 986

Cation_ATPase_C; Cation transporting ATPase, C-terminus

pfam00690
Location:4 → 72

Cation_ATPase_N; Cation transporter/ATPase, N-terminus

pfam12710
Location:605 → 711

HAD; haloacid dehalogenase-like hydrolase

pfam13246
Location:419 → 527

Cation_ATPase; Cation transport ATPase (P-type)
NM_009722.3 → NP_033852.1 sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform a

See identical proteins and their annotated locations for NP_033852.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (a), also known as SERCA2A, has a shorter and distinct C-terminus compared to isoform b.

Source sequence(s)

AK220538, BC054748, CJ162528

Consensus CDS

CCDS57379.1

UniProtKB/TrEMBL

Q5DTI2

Related

ENSMUSP00000136104.2, ENSMUST00000177974.8

Conserved Domains (6) summary

TIGR01116
Location:53 → 988

ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase

pfam00122
Location:93 → 340

E1-E2_ATPase; E1-E2 ATPase

pfam00689
Location:783 → 986

Cation_ATPase_C; Cation transporting ATPase, C-terminus

pfam00690
Location:4 → 72

Cation_ATPase_N; Cation transporter/ATPase, N-terminus

pfam12710
Location:605 → 711

HAD; haloacid dehalogenase-like hydrolase

pfam13246
Location:419 → 527

Cation_ATPase; Cation transport ATPase (P-type)

RNA

NR_027838.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) represents a longer 3' UTR, compared to variant 1. This variant is represented as non-coding because the additional splicing in the 3' UTR renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AK220538, BC054531, CJ162528