Nek9 NIMA (never in mitosis gene a)-related expressed kinase 9 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nek9provided by MGI
Official Full Name: NIMA (never in mitosis gene a)-related expressed kinase 9provided by MGI
Primary source: MGI:MGI:2387995
See related: Ensembl:ENSMUSG00000034290 AllianceGenome:MGI:2387995
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: C130021H08Rik
Summary: Predicted to enable protein kinase activator activity; protein kinase binding activity; and protein serine/threonine kinase activity. Predicted to be involved in mitotic cell cycle and regulation of mitotic cell cycle. Predicted to be located in cytoplasm and nucleus. Predicted to colocalize with centrosome. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome. Orthologous to human NEK9 (NIMA related kinase 9). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in bladder adult (RPKM 19.2), heart adult (RPKM 16.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 D2; 12 39.63 cM

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (85346288..85386136, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (85299514..85339362, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Involvement of NEK2 and NEK9 in LPS - induced endothelial barrier dysfunction.
Title: Involvement of NEK2 and NEK9 in LPS - induced endothelial barrier dysfunction.
NEK9 regulates primary cilia formation by acting as a selective autophagy adaptor for MYH9/myosin IIA.
Title: NEK9 regulates primary cilia formation by acting as a selective autophagy adaptor for MYH9/myosin IIA.
NEK9 is a critical component of the replication stress response that promotes CHK1 activity, maintaining genome integrity following challenges to DNA replication.
Title: A gemcitabine sensitivity screen identifies a role for NEK9 in the replication stress response.
Knockdown of Nek9 also impaired the spindle-pole localization of gamma-tubulin and resulted in retention of the spindle assembly checkpoint protein Bub3 at the kinetochores.
Title: Nek9 regulates spindle organization and cell cycle progression during mouse oocyte meiosis and its location in early embryo mitosis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Gene trapped (1)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Nek9 (e-PCR), detects polymorphism
- UniSTS:527447

AV046379 (e-PCR)
- UniSTS:165830

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activator activity	ISO Inferred from Sequence Orthology more info
enables protein kinase activator activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in mitotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of mitotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in regulation of mitotic cell cycle	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
colocalizes_with centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
colocalizes_with centrosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: serine/threonine-protein kinase Nek9

Names: nercc1 kinase; never in mitosis A-related kinase 9; nimA-related protein kinase 9

NP_660120.2

EC 2.7.11.1

XP_006515771.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145138.2 → NP_660120.2 serine/threonine-protein kinase Nek9

See identical proteins and their annotated locations for NP_660120.2

Status: VALIDATED

Source sequence(s)

AK173323, BQ964444, BY343854, CD775651

Consensus CDS

CCDS26057.1

UniProtKB/Swiss-Prot

Q148U2, Q8K1R7, Q8R3P1

UniProtKB/TrEMBL

Q69Z43

Related

ENSMUSP00000049056.8, ENSMUST00000040992.8

Conserved Domains (3) summary

smart00220
Location:52 → 296

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd08221
Location:51 → 296

STKc_Nek9; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 9

pfam00415
Location:500 → 547

RCC1; Regulator of chromosome condensation (RCC1) repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

85346288..85386136 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006515708.5 → XP_006515771.1 serine/threonine-protein kinase Nek9 isoform X1

Conserved Domains (4) summary

COG5184
Location:136 → 479

ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

cl30263
Location:692 → 746

PRK14127; cell division regulator GpsB

pfam00415
Location:459 → 514

RCC1; Regulator of chromosome condensation (RCC1) repeat

cl21453
Location:2 → 87

PKc_like; Protein Kinases, catalytic domain