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    Hic2 hypermethylated in cancer 2 [ Mus musculus (house mouse) ]

    Gene ID: 58180, updated on 27-Nov-2024

    Summary

    Official Symbol
    Hic2provided by MGI
    Official Full Name
    hypermethylated in cancer 2provided by MGI
    Primary source
    MGI:MGI:1929869
    See related
    Ensembl:ENSMUSG00000050240 AllianceGenome:MGI:1929869
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HRG22; mKIAA1020
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be active in nucleus. Is expressed in central nervous system; extraembryonic component; female reproductive system; heart; and urinary system. Orthologous to human HIC2 (HIC ZBTB transcriptional repressor 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in placenta adult (RPKM 11.4), CNS E11.5 (RPKM 5.1) and 26 other tissues See more
    Orthologs
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    Genomic context

    See Hic2 in Genome Data Viewer
    Location:
    16 A3; 16 10.68 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (17051451..17081294)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (17233587..17263430)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_40246 Neighboring gene predicted gene, 22129 Neighboring gene RIMS binding protein 3 Neighboring gene STARR-positive B cell enhancer ABC_E7430 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:17276268-17276485 Neighboring gene transmembrane protein 191 Neighboring gene phosphatidylinositol 4-kinase alpha Neighboring gene serine (or cysteine) peptidase inhibitor, clade D, member 1 Neighboring gene predicted gene, 24927

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (4)  1 citation
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    hypermethylated in cancer 2 protein
    Names
    hic-2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178922.3NP_849253.2  hypermethylated in cancer 2 protein

      See identical proteins and their annotated locations for NP_849253.2

      Status: VALIDATED

      Source sequence(s)
      AK129266, BC050867, BQ954078, BQ965108
      Consensus CDS
      CCDS27999.1
      UniProtKB/Swiss-Prot
      Q3U030, Q3ULP4, Q5K036, Q8BSZ9, Q8C3T5, Q9JLZ6
      Related
      ENSMUSP00000087656.6, ENSMUST00000090190.14
      Conserved Domains (6) summary
      smart00225
      Location:47141
      BTB; Broad-Complex, Tramtrack and Bric a brac
      COG5048
      Location:563617
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:539559
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:537559
      zf-C2H2; Zinc finger, C2H2 type
      pfam00651
      Location:40140
      BTB; BTB/POZ domain
      pfam13465
      Location:580604
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      17051451..17081294
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)