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    Atp5me ATP synthase membrane subunit e [ Mus musculus (house mouse) ]

    Gene ID: 11958, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Atp5meprovided by MGI
    Official Full Name
    ATP synthase membrane subunit eprovided by MGI
    Primary source
    MGI:MGI:106636
    See related
    Ensembl:ENSMUSG00000050856 AllianceGenome:MGI:106636
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lfm1; Atp5i; Atp5k; 2610008D24Rik
    Summary
    Predicted to contribute to proton-transporting ATP synthase activity, rotational mechanism. Predicted to be involved in proton motive force-driven mitochondrial ATP synthesis. Located in mitochondrion. Is expressed in alimentary system; brown fat; hemolymphoid system; liver; and urinary system. Orthologous to human ATP5ME (ATP synthase membrane subunit e). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 62.8), heart adult (RPKM 59.6) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Atp5me in Genome Data Viewer
    Location:
    5 F; 5 53.11 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (108581112..108582265, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (108433246..108434399, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide Neighboring gene predicted gene, 52851 Neighboring gene predicted gene, 34254 Neighboring gene STARR-positive B cell enhancer ABC_E9648 Neighboring gene predicted gene, 34319 Neighboring gene solute carrier family 49 member 3 Neighboring gene STARR-positive B cell enhancer ABC_E6360 Neighboring gene polycomb group ring finger 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Diet-disease interactions at the molecular level: an experimental paradigm. Kaput J, et al. J Nutr, 1994 Aug. PMID 7914920
    2. F1Fo-ATPase subunit e gene isolated in a screen for diet regulated genes. Elliott TS, et al. Biochem Biophys Res Commun, 1993 Jan 15. PMID 7678489
    3. Mouse DNA polymerase epsilon gene (Pole) maps to chromosome 5. Goldsby RE, et al. Mamm Genome, 1998 Jan. PMID 9434959
    4. Testis beta-1,4-galactosyltransferase gene maps to mouse chromosome 5. Kaname T, et al. Genomics, 1998 Oct 1. PMID 9787086
    5. Primary structure, neural-specific expression, and chromosomal localization of Cux-2, a second murine homeobox gene related to Drosophila cut. Quaggin SE, et al. J Biol Chem, 1996 Sep 13. PMID 8798433

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC107302

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables proton-transporting ATP synthase activity, rotational mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to proton-transporting ATP synthase activity, rotational mechanism ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in proton motive force-driven mitochondrial ATP synthesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton motive force-driven mitochondrial ATP synthesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of proton-transporting ATP synthase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proton-transporting ATP synthase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of proton-transporting ATP synthase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of proton-transporting ATP synthase complex, coupling factor F(o) IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proton-transporting ATP synthase complex, coupling factor F(o) ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ATP synthase subunit e, mitochondrial
    Names
    ATP synthase, H+ transporting, mitochondrial F1F0 complex, subunit E
    ATPase subunit e
    NP_031533.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007507.3 → NP_031533.2  ATP synthase subunit e, mitochondrial

      See identical proteins and their annotated locations for NP_031533.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer, protein-coding transcript.
      Source sequence(s)
      AC158912, BC028438, CO044079
      Consensus CDS
      CCDS39204.1
      UniProtKB/Swiss-Prot
      P70342, Q06185
      UniProtKB/TrEMBL
      Q5EBI8
      Related
      ENSMUSP00000051222.10, ENSMUST00000049628.16
      Conserved Domains (1) summary
      pfam05680
      Location:2 → 35
      ATP-synt_E; ATP synthase E chain

    RNA

    1. NR_154996.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon compared to variant 1. The transcript is being represented as non-protein coding since the putative protein would be only 38 aa long.
      Source sequence(s)
      AC158912, AK011342, CO044079
      Related
      ENSMUST00000118632.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      108581112..108582265 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06185.2 GenPept UniProtKB/Swiss-Prot:Q06185

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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