Gtf3c4 general transcription factor IIIC, polypeptide 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gtf3c4provided by MGI
Official Full Name: general transcription factor IIIC, polypeptide 4provided by MGI
Primary source: MGI:MGI:2138937
See related: Ensembl:ENSMUSG00000035666 AllianceGenome:MGI:2138937
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: KAT12; TFIIIC90; 5330400C03
Summary: Predicted to enable DNA binding activity; RNA polymerase III general transcription initiation factor activity; and histone acetyltransferase activity. Predicted to be involved in chromatin remodeling and transcription initiation at RNA polymerase III promoter. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be part of transcription factor TFIIIC complex. Is expressed in limb. Orthologous to human GTF3C4 (general transcription factor IIIC subunit 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 8.3), whole brain E14.5 (RPKM 7.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 A3; 2 19.38 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (28712311..28730628, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (28822299..28840360, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:234357

AU017413 (e-PCR)
- UniSTS:178596

AU014771 (e-PCR)
- UniSTS:207310

AI426938 (e-PCR)
- UniSTS:158937

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase III general transcription initiation factor activity	IEA Inferred from Electronic Annotation more info
enables histone H2AK5 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AK9 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BK12 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BK5 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K122 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K14 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K18 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K23 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K27 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K36 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K4 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K56 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K9 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4K12 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4K16 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4K5 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4K8 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in transcription initiation at RNA polymerase III promoter	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of transcription factor TFIIIC complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription factor TFIIIC complex	IEA Inferred from Electronic Annotation more info
part_of transcription factor TFIIIC complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: general transcription factor 3C polypeptide 4

Names: TF3C-delta; TFIIIC 90 kDa subunit; general transcription factor IIIC 4; transcription factor IIIC 90 kDa subunit; transcription factor IIIC subunit delta

NP_001159505.1

EC 2.3.1.48

NP_766565.2

EC 2.3.1.48

XP_006498141.1

EC 2.3.1.48

XP_036018130.1

EC 2.3.1.48

XP_036018131.1

EC 2.3.1.48

XP_036018132.1

EC 2.3.1.48

XP_036018133.1

EC 2.3.1.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001166033.1 → NP_001159505.1 general transcription factor 3C polypeptide 4 isoform 2

See identical proteins and their annotated locations for NP_001159505.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an alternate exon compared to variant 1, that causes a frameshift and a downstream translation start site to be used. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AL732526, BC117919, BU610856, CN530016

Consensus CDS

CCDS50550.1

UniProtKB/TrEMBL

E9Q2B0, Q3UJL1

Related

ENSMUSP00000132171.2, ENSMUST00000171404.8

Conserved Domains (2) summary

pfam12660
Location:599 → 671

zf-TFIIIC; Putative zinc-finger of transcription factor IIIC complex

pfam12657
Location:1 → 109

TFIIIC_delta; Transcription factor IIIC subunit delta N-term
NM_172977.3 → NP_766565.2 general transcription factor 3C polypeptide 4 isoform 1

See identical proteins and their annotated locations for NP_766565.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AL732526, BC117919, CN530016

Consensus CDS

CCDS15847.1

UniProtKB/Swiss-Prot

Q148Y1, Q8BKZ4, Q8BMQ2

UniProtKB/TrEMBL

Q501L4

Related

ENSMUSP00000042265.6, ENSMUST00000037117.6

Conserved Domains (2) summary

pfam12657
Location:61 → 250

TFIIIC_delta; Transcription factor IIIC subunit delta N-term

pfam12660
Location:740 → 812

zf-TFIIIC; Putative zinc-finger of transcription factor IIIC complex

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

28712311..28730628 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036162237.1 → XP_036018130.1 general transcription factor 3C polypeptide 4 isoform X1

UniProtKB/TrEMBL

Q501L4

Conserved Domains (1) summary

pfam12657
Location:61 → 250

TFIIIC_delta; Transcription factor IIIC subunit delta N-term
XM_036162239.1 → XP_036018132.1 general transcription factor 3C polypeptide 4 isoform X3

UniProtKB/TrEMBL

Q3UJL1

Conserved Domains (1) summary

pfam12657
Location:1 → 109

TFIIIC_delta; Transcription factor IIIC subunit delta N-term
XM_036162240.1 → XP_036018133.1 general transcription factor 3C polypeptide 4 isoform X3

UniProtKB/TrEMBL

Q3UJL1

Conserved Domains (1) summary

pfam12657
Location:1 → 109

TFIIIC_delta; Transcription factor IIIC subunit delta N-term
XM_006498078.5 → XP_006498141.1 general transcription factor 3C polypeptide 4 isoform X2

See identical proteins and their annotated locations for XP_006498141.1

UniProtKB/TrEMBL

E9Q2B0, Q3UJL1

Conserved Domains (2) summary

pfam12660
Location:599 → 671

zf-TFIIIC; Putative zinc-finger of transcription factor IIIC complex

pfam12657
Location:1 → 109

TFIIIC_delta; Transcription factor IIIC subunit delta N-term
XM_036162238.1 → XP_036018131.1 general transcription factor 3C polypeptide 4 isoform X2

UniProtKB/TrEMBL

E9Q2B0, Q3UJL1

Conserved Domains (2) summary

pfam12660
Location:599 → 671

zf-TFIIIC; Putative zinc-finger of transcription factor IIIC complex

pfam12657
Location:1 → 109

TFIIIC_delta; Transcription factor IIIC subunit delta N-term