Arhgap28 Rho GTPase activating protein 28 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Arhgap28provided by MGI
Official Full Name: Rho GTPase activating protein 28provided by MGI
Primary source: MGI:MGI:2147003
See related: Ensembl:ENSMUSG00000024043 AllianceGenome:MGI:2147003
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: E130310N06
Summary: Predicted to enable GTPase activator activity. Acts upstream of or within negative regulation of stress fiber assembly. Predicted to be located in cell junction and nucleoplasm. Predicted to be active in cytoplasm. Is expressed in lower leg bone. Human ortholog(s) of this gene implicated in allergic disease. Orthologous to human ARHGAP28 (Rho GTPase activating protein 28). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in limb E14.5 (RPKM 7.1), ovary adult (RPKM 4.6) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 E1.1- E1.2; 17 38.9 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (68149701..68311185, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (67842706..68004197, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Together, these data suggest that the regulation of Rho by RhoGAPs, including Arhgap28, during the assembly and development of mechanically strong tissues is complex and may involve multiple RhoGAPs.
Title: Arhgap28 is a RhoGAP that inactivates RhoA and downregulates stress fibers.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW550892 (e-PCR)
- UniSTS:181053

AU044757 (e-PCR)
- UniSTS:160687

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of GTP binding	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of stress fiber assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of stress fiber assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of actin filament polymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of small GTPase mediated signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell junction	IEA Inferred from Electronic Annotation more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: rho GTPase-activating protein 28

Names: rho-type GTPase-activating protein 28

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001347410.1 → NP_001334339.1 rho GTPase-activating protein 28 isoform 2

Status: VALIDATED

Source sequence(s)

AC154823, AC164159, CO043770

Consensus CDS

CCDS84329.1

UniProtKB/TrEMBL

A0A2X0SYT7

Related

ENSMUSP00000130960.2, ENSMUST00000163865.8
NM_001426794.1 → NP_001413723.1 rho GTPase-activating protein 28 isoform 3

Status: VALIDATED

Source sequence(s)

AC154823, AC164159

UniProtKB/TrEMBL

E9Q642

Related

ENSMUSP00000128194.2, ENSMUST00000164647.8
NM_001426795.1 → NP_001413724.1 rho GTPase-activating protein 28 isoform 3

Status: VALIDATED

Source sequence(s)

AC154823, AC164159

UniProtKB/TrEMBL

E9Q642
NM_172964.4 → NP_766552.3 rho GTPase-activating protein 28 isoform 1

See identical proteins and their annotated locations for NP_766552.3

Status: VALIDATED

Source sequence(s)

AK087523, AK133720, AK141901, BB372888

Consensus CDS

CCDS28950.1

UniProtKB/Swiss-Prot

Q3TSH7, Q3UR11, Q3UZQ7, Q69ZM1, Q6NY11, Q8BN58

UniProtKB/TrEMBL

A0A2X0SYT7

Related

ENSMUSP00000024840.6, ENSMUST00000024840.12

Conserved Domains (1) summary

cd04391
Location:381 → 592

RhoGAP_ARHGAP18; RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

68149701..68311185 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036160630.1 → XP_036016523.1 rho GTPase-activating protein 28 isoform X1

UniProtKB/TrEMBL

A0A2X0SYT7

Conserved Domains (1) summary

cd04391
Location:408 → 619

RhoGAP_ARHGAP18; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but ...
XM_006524343.5 → XP_006524406.1 rho GTPase-activating protein 28 isoform X2

See identical proteins and their annotated locations for XP_006524406.1

UniProtKB/TrEMBL

A0A2X0SYT7, E9Q642

Conserved Domains (1) summary

cd04391
Location:331 → 542

RhoGAP_ARHGAP18; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but ...