Sema7a sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sema7aprovided by MGI
Official Full Name: sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7Aprovided by MGI
Primary source: MGI:MGI:1306826
See related: Ensembl:ENSMUSG00000038264 AllianceGenome:MGI:1306826
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Semal; CDw108; sema L; sema K1; H-Sema-L; M-Sema-L; H-Sema K1; 2900057C09Rik
Summary: Enables integrin binding activity. Involved in several processes, including integrin-mediated signaling pathway; positive regulation of ERK1 and ERK2 cascade; and positive regulation of macrophage cytokine production. Acts upstream of or within nervous system development; positive regulation of axon extension; and positive regulation of protein phosphorylation. Located in external side of plasma membrane. Is active in GABA-ergic synapse and presynapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Human ortholog(s) of this gene implicated in progressive familial intrahepatic cholestasis. Orthologous to human SEMA7A (semaphorin 7A (JohnMiltonHagen blood group)). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in ovary adult (RPKM 69.7), cerebellum adult (RPKM 47.2) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 B; 9 31.63 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (57846879..57870148)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (57939596..57962865)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Semaphorin 7a regulates inflammatory mediators and permeability in retinal endothelial cells.
Title: Semaphorin 7a regulates inflammatory mediators and permeability in retinal endothelial cells.
Sema7A protects against high-fat diet-induced obesity and hepatic steatosis by regulating adipo/lipogenesis.
Title: Sema7A protects against high-fat diet-induced obesity and hepatic steatosis by regulating adipo/lipogenesis.
Semaphorin 7A interacts with nuclear factor NF-kappa-B p105 via integrin beta1 and mediates inflammation.
Title: Semaphorin 7A interacts with nuclear factor NF-kappa-B p105 via integrin β1 and mediates inflammation.
Knockdown of SEMA7A alleviates MPP[+] -induced apoptosis and inflammation in BV2 microglia via PPAR-gamma activation and MAPK inactivation.
Title: Knockdown of SEMA7A alleviates MPP(+) -induced apoptosis and inflammation in BV2 microglia via PPAR-γ activation and MAPK inactivation.
SEMA7AR148W mutation promotes lipid accumulation and NAFLD progression via increased localization on the hepatocyte surface.
Title: SEMA7AR148W mutation promotes lipid accumulation and NAFLD progression via increased localization on the hepatocyte surface.
Semaphorin 7A Accelerates the Inflammatory Osteolysis of Periapical Lesions.
Title: Semaphorin 7A Accelerates the Inflammatory Osteolysis of Periapical Lesions.
Anoikis resistance in mammary epithelial cells is mediated by semaphorin 7a.
Title: Anoikis resistance in mammary epithelial cells is mediated by semaphorin 7a.
A homozygous R148W mutation in Semaphorin 7A causes progressive familial intrahepatic cholestasis.
Title: A homozygous R148W mutation in Semaphorin 7A causes progressive familial intrahepatic cholestasis.
The olfactory critical period is determined by activity-dependent Sema7A/PlxnC1 signaling within glomeruli.
Title: The olfactory critical period is determined by activity-dependent Sema7A/PlxnC1 signaling within glomeruli.
Sema7A is crucial for resolution of severe inflammation.
Title: Sema7A is crucial for resolution of severe inflammation.

Submit: New GeneRIF Correction See all GeneRIFs (41)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MDB0432 (e-PCR)
- UniSTS:125019

Sema7a (e-PCR), detects polymorphism
- UniSTS:536494

RH125166 (e-PCR)
- UniSTS:161988

SEMA7A_817 (e-PCR)
- UniSTS:277704

SEMA7A_V139 (e-PCR)
- UniSTS:277704

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chemorepellent activity	IBA Inferred from Biological aspect of Ancestor more info
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables integrin binding	IPI Inferred from Physical Interaction more info	PubMed
NOT enables neuropilin binding	IBA Inferred from Biological aspect of Ancestor more info
enables semaphorin receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables semaphorin receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within axon extension	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within axon extension	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within axon extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in integrin-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in integrin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in integrin-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in neural crest cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within olfactory lobe development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within olfactory lobe development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of axon extension	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of axon extension	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of axon extension	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of macrophage cytokine production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of inflammatory response	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synapse maturation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synapse maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in semaphorin-plexin signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in GABA-ergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info
is_active_in presynapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: semaphorin-7A

Names: semaphorin-K1; semaphorin-L

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011352.3 → NP_035482.1 semaphorin-7A precursor

See identical proteins and their annotated locations for NP_035482.1

Status: VALIDATED

Source sequence(s)

AC165246

Consensus CDS

CCDS23235.1

UniProtKB/Swiss-Prot

O88371, Q9QUR8

Related

ENSMUSP00000042211.8, ENSMUST00000043059.9

Conserved Domains (3) summary

cd11243
Location:70 → 489

Sema_7A; The Sema domain, a protein interacting module, of semaphorin 7A (Sema7A, also called CD108)

pfam01437
Location:491 → 518

PSI; Plexin repeat

cl11960
Location:547 → 617

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

57846879..57870148

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030244149.1 → XP_030100009.1 semaphorin-7A isoform X2

Conserved Domains (4) summary

pfam01437
Location:275 → 324

PSI; Plexin repeat

cd00096
Location:331 → 337

Ig; Ig strand A [structural motif]

cl11960
Location:331 → 401

Ig; Immunoglobulin domain

cl15693
Location:1 → 273

Sema; The Sema domain, a protein interacting module, of semaphorins and plexins
XM_006510889.4 → XP_006510952.1 semaphorin-7A isoform X1

See identical proteins and their annotated locations for XP_006510952.1

Conserved Domains (3) summary

smart00423
Location:333 → 360

PSI; domain found in Plexins, Semaphorins and Integrins

cl11960
Location:389 → 459

Ig; Immunoglobulin domain

cl15693
Location:2 → 331

Sema; The Sema domain, a protein interacting module, of semaphorins and plexins
XM_036154744.1 → XP_036010637.1 semaphorin-7A isoform X2

Conserved Domains (4) summary

pfam01437
Location:275 → 324

PSI; Plexin repeat

cd00096
Location:331 → 337

Ig; Ig strand A [structural motif]

cl11960
Location:331 → 401

Ig; Immunoglobulin domain

cl15693
Location:1 → 273

Sema; The Sema domain, a protein interacting module, of semaphorins and plexins
XM_006510888.4 → XP_006510951.1 semaphorin-7A isoform X1

See identical proteins and their annotated locations for XP_006510951.1

Conserved Domains (3) summary

smart00423
Location:333 → 360

PSI; domain found in Plexins, Semaphorins and Integrins

cl11960
Location:389 → 459

Ig; Immunoglobulin domain

cl15693
Location:2 → 331

Sema; The Sema domain, a protein interacting module, of semaphorins and plexins