Ptpn9 protein tyrosine phosphatase, non-receptor type 9 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ptpn9provided by MGI
Official Full Name: protein tyrosine phosphatase, non-receptor type 9provided by MGI
Primary source: MGI:MGI:1928376
See related: Ensembl:ENSMUSG00000032290 AllianceGenome:MGI:1928376
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MEG2
Summary: Predicted to enable protein tyrosine phosphatase activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within negative regulation of neuron projection development; peptidyl-tyrosine dephosphorylation; and positive regulation of protein localization to plasma membrane. Located in neuron projection terminus. Is expressed in several structures, including brain; genitourinary system; liver; lung; and spleen. Orthologous to human PTPN9 (protein tyrosine phosphatase non-receptor type 9). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 23.8), limb E14.5 (RPKM 15.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 B; 9 30.7 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (56902252..56970092)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (56994968..57062808)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The binding of PKCepsilon and MEG2 to STAT3 regulates IL-6-mediated microglial hyperalgesia during inflammatory pain.
Title: The binding of PKCε and MEG2 to STAT3 regulates IL-6-mediated microglial hyperalgesia during inflammatory pain.
Phloridzin Acts as an Inhibitor of Protein-Tyrosine Phosphatase MEG2 Relevant to Insulin Resistance.
Title: Phloridzin Acts as an Inhibitor of Protein-Tyrosine Phosphatase MEG2 Relevant to Insulin Resistance.
the heterozygous loss of Meg2 in mice is sufficient to cause intraocular pressure elevation and glaucomatous neurodegeneration.
Title: Heterozygous Meg2 Ablation Causes Intraocular Pressure Elevation and Progressive Glaucomatous Neurodegeneration.
As a result, overexpression of PTP-MEG2 down-regulates NGF/TrkA signaling and blocks neurite outgrowth and differentiation
Title: The Protein Tyrosine Phosphatase MEG2 Regulates the Transport and Signal Transduction of Tropomyosin Receptor Kinase A.
role in the negative regulation of hepatic insulin signaling
Title: Identification of the tyrosine phosphatase PTP-MEG2 as an antagonist of hepatic insulin signaling.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ptpn9 (e-PCR), detects polymorphism
- UniSTS:536486

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables histone H2AXY142 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables protein tyrosine phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein tyrosine phosphatase activity, metal-dependent	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of neuron projection development	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within peptidyl-tyrosine dephosphorylation	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within positive regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in neuron projection terminus	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection terminus	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: tyrosine-protein phosphatase non-receptor type 9

Names: PTPase MEG2; Protein-tyrosine phosphatase, non-receptor type 9 (Protein-tyrosine phosphatase MEG2) (PTPase-MEG2); protein-tyrosine phosphatase MEG2

NP_062625.2

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019651.2 → NP_062625.2 tyrosine-protein phosphatase non-receptor type 9

See identical proteins and their annotated locations for NP_062625.2

Status: PROVISIONAL

Source sequence(s)

BC053017

Consensus CDS

CCDS23215.1

UniProtKB/Swiss-Prot

O35239, Q7TSK0

UniProtKB/TrEMBL

Q2M4G8

Related

ENSMUSP00000034832.7, ENSMUST00000034832.8

Conserved Domains (4) summary

smart00194
Location:302 → 573

PTPc; Protein tyrosine phosphatase, catalytic domain

smart00516
Location:90 → 240

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

smart01100
Location:20 → 66

CRAL_TRIO_N; CRAL/TRIO, N-terminal domain

cd00047
Location:329 → 573

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...