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    Bcam basal cell adhesion molecule [ Mus musculus (house mouse) ]

    Gene ID: 57278, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Bcamprovided by MGI
    Official Full Name
    basal cell adhesion moleculeprovided by MGI
    Primary source
    MGI:MGI:1929940
    See related
    Ensembl:ENSMUSG00000002980 AllianceGenome:MGI:1929940
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lu; Gplu; B-CAM; 1200005K12Rik
    Summary
    Enables laminin receptor activity. Acts upstream of or within cell adhesion. Located in cell surface and plasma membrane. Is expressed in several structures, including genitourinary system; nervous system; skin; small intestine; and spleen. Orthologous to human BCAM (basal cell adhesion molecule (Lutheran blood group)). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in lung adult (RPKM 346.1), ovary adult (RPKM 101.5) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Bcam in Genome Data Viewer
    Location:
    7 A3; 7 9.94 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (19490063..19504457, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (19756138..19770532, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene translocase of outer mitochondrial membrane 40 Neighboring gene predicted gene, 38955 Neighboring gene nectin cell adhesion molecule 2 Neighboring gene STARR-seq mESC enhancer starr_18217 Neighboring gene STARR-seq mESC enhancer starr_18218 Neighboring gene predicted gene, 34744 Neighboring gene STARR-seq mESC enhancer starr_18221 Neighboring gene Casitas B-lineage lymphoma c Neighboring gene STARR-positive B cell enhancer ABC_E2816 Neighboring gene STARR-seq mESC enhancer starr_18223 Neighboring gene STARR-positive B cell enhancer ABC_E1721 Neighboring gene B cell leukemia/lymphoma 3 Neighboring gene predicted gene 16174

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genetic inactivation of the laminin alpha5 chain receptor Lu/BCAM leads to kidney and intestinal abnormalities in the mouse. Rahuel C, et al. Am J Physiol Renal Physiol, 2008 Feb. PMID 18032551
    2. Lutheran/basal cell adhesion molecule accelerates progression of crescentic glomerulonephritis in mice. Huang J, et al. Kidney Int, 2014 May. PMID 24429403, Free PMC Article
    3. Apoptosis and tissue thinning contribute to symmetric cell division in the developing mouse epidermis in a nonautonomous way. Soffer A, et al. PLoS Biol, 2022 Aug. PMID 35969606, Free PMC Article
    4. Differential expression of Lutheran/BCAM regulates biliary tissue remodeling in ductular reaction during liver regeneration. Miura Y, et al. Elife, 2018 Jul 30. PMID 30059007, Free PMC Article
    5. Characterization of a mouse liminin receptor gene homologous to the human blood group Lutheran gene. Rahuel C, et al. Immunogenetics, 1999 Dec. PMID 10630290

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Lutheran (Lu)/Basal cell adhesion molecule (BCAM) regulates the morphogenesis of DR depending on liver disease models.
      Title: Differential expression of Lutheran/BCAM regulates biliary tissue remodeling in ductular reaction during liver regeneration.
    2. Lu/BCAM may have a critical role in facilitating the accumulation of monocytes and macrophages, thereby exacerbating renal injury in crescentic glomerulonephritis.
      Title: Lutheran/basal cell adhesion molecule accelerates progression of crescentic glomerulonephritis in mice.
    3. Lutheran (Lu), also known as basal cell adhesion molecule (B-CAM), competes with integrins for binding to laminin alpha5, a subunit of LM-511, a major component of basement membranes.
      Title: The lutheran/basal cell adhesion molecule promotes tumor cell migration by modulating integrin-mediated cell attachment to laminin-511 protein.
    4. Lu/BCAM, as a laminin receptor, is involved in vivo in the maintenance of normal basement membrane organization in the kidney and intestine.
      Title: Genetic inactivation of the laminin alpha5 chain receptor Lu/BCAM leads to kidney and intestinal abnormalities in the mouse.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables laminin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables laminin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables laminin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables laminin receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables laminin receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cell-matrix adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    basal cell adhesion molecule
    Names
    Auberger b antigen
    B-CAM cell surface glycoprotein
    Lutheran blood group
    lutheran antigen
    lutheran glycoprotein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020486.2 → NP_065232.1  basal cell adhesion molecule precursor

      See identical proteins and their annotated locations for NP_065232.1

      Status: VALIDATED

      Source sequence(s)
      AF109160, AF221507, AF346663, BB190832
      Consensus CDS
      CCDS39803.1
      UniProtKB/Swiss-Prot
      Q9ESS5, Q9JKB2, Q9R069
      UniProtKB/TrEMBL
      Q99K86
      Related
      ENSMUSP00000003061.8, ENSMUST00000003061.14
      Conserved Domains (5) summary
      smart00408
      Location:276 → 334
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:32 → 136
      IG_like; Immunoglobulin like
      pfam08205
      Location:144 → 241
      C2-set_2; CD80-like C2-set immunoglobulin domain
      pfam13895
      Location:371 → 438
      Ig_2; Immunoglobulin domain
      cl11960
      Location:460 → 523
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      19490063..19504457 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9R069.1 GenPept UniProtKB/Swiss-Prot:Q9R069

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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