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    Mdm2 transformed mouse 3T3 cell double minute 2 [ Mus musculus (house mouse) ]

    Gene ID: 17246, updated on 14-Jan-2025

    Summary

    Official Symbol
    Mdm2provided by MGI
    Official Full Name
    transformed mouse 3T3 cell double minute 2provided by MGI
    Primary source
    MGI:MGI:96952
    See related
    Ensembl:ENSMUSG00000020184 AllianceGenome:MGI:96952
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mdm-2; 1700007J15Rik
    Summary
    Enables p53 binding activity and ubiquitin protein ligase activity. Involved in apoptotic process and positive regulation of muscle cell differentiation. Acts upstream of or within several processes, including blood vessel remodeling; circulatory system development; and traversing start control point of mitotic cell cycle. Located in cytoplasm and nucleolus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in chronic myeloid leukemia; endocrine gland cancer (multiple); glioblastoma; ichthyosis; and sarcoma. Orthologous to human MDM2 (MDM2 proto-oncogene). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in testis adult (RPKM 10.8), CNS E11.5 (RPKM 9.8) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Mdm2 in Genome Data Viewer
    Location:
    10 D2; 10 66.32 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (117524780..117546663, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (117688875..117710758, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32365 Neighboring gene STARR-positive B cell enhancer mm9_chr10:117066381-117066682 Neighboring gene carboxypeptidase M Neighboring gene STARR-positive B cell enhancer ABC_E580 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:117089250-117089433 Neighboring gene STARR-positive B cell enhancer ABC_E9133 Neighboring gene STARR-positive B cell enhancer ABC_E8368 Neighboring gene predicted gene, 25709 Neighboring gene STARR-positive B cell enhancer ABC_E8369 Neighboring gene STARR-positive B cell enhancer ABC_E8869 Neighboring gene STARR-seq mESC enhancer starr_27991 Neighboring gene STARR-seq mESC enhancer starr_27993 Neighboring gene STARR-seq mESC enhancer starr_27994 Neighboring gene STARR-seq mESC enhancer starr_27995 Neighboring gene predicted gene, 53636 Neighboring gene solute carrier family 35, member E3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Items 1 - 25 of 33
    Function Evidence Code Pubs
    enables 5S rRNA binding  
    enables 5S rRNA binding  
    enables NEDD8 ligase activity  
    enables NEDD8 ligase activity  
    enables SUMO transferase activity  
    enables disordered domain specific binding  
    enables disordered domain specific binding  
    enables enzyme binding  
    enables identical protein binding  
    enables identical protein binding  
    enables ligase activity  
    enables ligase activity  
    enables p53 binding PubMed 
    enables p53 binding  
    enables peroxisome proliferator activated receptor binding  
    enables peroxisome proliferator activated receptor binding  
    enables protein binding PubMed 
    enables protein domain specific binding  
    enables receptor serine/threonine kinase binding  
    enables receptor serine/threonine kinase binding  
    enables ribonucleoprotein complex binding  
    enables ribonucleoprotein complex binding  
    enables ubiquitin binding  
    enables ubiquitin binding  
    enables ubiquitin protein ligase activity  
    enables ubiquitin protein ligase activity PubMed 
    enables ubiquitin protein ligase activity  
    enables ubiquitin protein ligase binding  
    enables ubiquitin protein ligase binding  
    enables ubiquitin-protein transferase activity PubMed 
    enables ubiquitin-protein transferase activity  
    enables zinc ion binding  
    enables zinc ion binding  
    Items 1 - 25 of 33
    Items 1 - 25 of 97
    Process Evidence Code Pubs
    involved_in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  
    involved_in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  
    involved_in amyloid fibril formation  
    involved_in amyloid fibril formation  
    involved_in apoptotic process PubMed 
    involved_in apoptotic process  
    acts_upstream_of_or_within atrial septum development PubMed 
    acts_upstream_of_or_within atrioventricular valve morphogenesis PubMed 
    acts_upstream_of_or_within blood vessel development PubMed 
    acts_upstream_of_or_within blood vessel remodeling PubMed 
    acts_upstream_of_or_within cardiac septum morphogenesis PubMed 
    acts_upstream_of cell cycle PubMed 
    involved_in cellular response to UV-C  
    involved_in cellular response to actinomycin D  
    involved_in cellular response to actinomycin D  
    involved_in cellular response to alkaloid  
    involved_in cellular response to estrogen stimulus  
    involved_in cellular response to gamma radiation  
    involved_in cellular response to gamma radiation  
    involved_in cellular response to growth factor stimulus  
    involved_in cellular response to hydrogen peroxide  
    involved_in cellular response to hypoxia  
    involved_in cellular response to peptide hormone stimulus  
    involved_in cellular response to vitamin B1  
    acts_upstream_of_or_within endocardial cushion morphogenesis PubMed 
    acts_upstream_of_or_within endocardial cushion morphogenesis PubMed 
    involved_in establishment of protein localization  
    involved_in establishment of protein localization  
    involved_in fibroblast activation  
    involved_in fibroblast activation  
    acts_upstream_of_or_within heart development PubMed 
    acts_upstream_of_or_within heart development PubMed 
    acts_upstream_of_or_within heart valve development PubMed 
    involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator  
    involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator  
    involved_in negative regulation of DNA-templated transcription  
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of gene expression  
    involved_in negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator  
    involved_in negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator  
    involved_in negative regulation of neuron projection development  
    involved_in negative regulation of neuron projection development  
    involved_in negative regulation of protein processing  
    involved_in negative regulation of protein processing  
    involved_in negative regulation of signal transduction by p53 class mediator  
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in negative regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within positive regulation of cell cycle PubMed 
    involved_in positive regulation of gene expression  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of mitotic cell cycle  
    involved_in positive regulation of mitotic cell cycle  
    involved_in positive regulation of muscle cell differentiation PubMed 
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process  
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process  
    involved_in positive regulation of protein export from nucleus  
    involved_in positive regulation of protein export from nucleus  
    involved_in positive regulation of vascular associated smooth muscle cell migration  
    involved_in positive regulation of vascular associated smooth muscle cell migration  
    involved_in positive regulation of vascular associated smooth muscle cell proliferation  
    involved_in positive regulation of vascular associated smooth muscle cell proliferation  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process  
    involved_in protein autoubiquitination  
    involved_in protein autoubiquitination  
    involved_in protein destabilization  
    involved_in protein destabilization  
    involved_in protein localization to nucleus  
    involved_in protein localization to nucleus  
    involved_in protein ubiquitination  
    involved_in protein ubiquitination  
    involved_in protein-containing complex assembly  
    involved_in protein-containing complex assembly  
    involved_in proteolysis involved in protein catabolic process  
    acts_upstream_of regulation of cell cycle  
    acts_upstream_of_or_within regulation of gene expression PubMed 
    acts_upstream_of_or_within regulation of heart rate PubMed 
    involved_in regulation of postsynaptic neurotransmitter receptor internalization  
    involved_in regulation of protein catabolic process  
    involved_in regulation of protein catabolic process at postsynapse, modulating synaptic transmission  
    involved_in response to cocaine  
    involved_in response to ether  
    involved_in response to formaldehyde  
    involved_in response to iron ion  
    involved_in response to magnesium ion  
    involved_in response to steroid hormone  
    involved_in response to toxic substance  
    involved_in response to water-immersion restraint stress  
    involved_in response to water-immersion restraint stress  
    involved_in response to xenobiotic stimulus  
    acts_upstream_of_or_within traversing start control point of mitotic cell cycle PubMed 
    involved_in ubiquitin-dependent protein catabolic process  
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process PubMed 
    involved_in ubiquitin-dependent protein catabolic process PubMed 
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process  
    involved_in ubiquitin-dependent protein catabolic process  
    acts_upstream_of_or_within ventricular septum development PubMed 
    Items 1 - 25 of 97
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    located_in cytosol  
    located_in glutamatergic synapse  
    located_in nuclear body  
    colocalizes_with nuclear body  
    is_active_in nucleolus  
    located_in nucleolus PubMed 
    located_in nucleolus  
    located_in nucleoplasm  
    located_in nucleus PubMed 
    located_in nucleus  
    located_in postsynaptic density  
    part_of protein-containing complex  
    part_of transcription repressor complex  
    part_of transcription repressor complex  

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase Mdm2
    Names
    RING-type E3 ubiquitin transferase Mdm2
    double minute 2 protein
    oncoprotein Mdm2
    p53-binding protein Mdm2
    NP_001275515.1
    NP_034916.1
    XP_017169311.1
    XP_036011554.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001288586.3NP_001275515.1  E3 ubiquitin-protein ligase Mdm2 isoform 2

      See identical proteins and their annotated locations for NP_001275515.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an internal exon in the 5' region, which results in translation initiation at a downstream AUG start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1. Variants 2-7 all encode the same isoform (2).
      Source sequence(s)
      AC132139
      Consensus CDS
      CCDS70110.1
      UniProtKB/TrEMBL
      Q3TVL4
      Related
      ENSMUSP00000100898.2, ENSMUST00000105263.9
      Conserved Domains (3) summary
      cd16783
      Location:384439
      mRING-HC-C2H2C4_MDM2; Modified RING finger, HC subclass (C2H2C4-type), found in E3 ubiquitin-protein ligase MDM2 and similar proteins
      pfam00641
      Location:248277
      zf-RanBP; Zn-finger in Ran binding protein and others
      cl38907
      Location:158
      SWIB-MDM2; SWIB/MDM2 domain family
    2. NM_001428611.1NP_001415540.1  E3 ubiquitin-protein ligase Mdm2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC132139
      UniProtKB/TrEMBL
      Q3TVL4
    3. NM_001428612.1NP_001415541.1  E3 ubiquitin-protein ligase Mdm2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC132139
      UniProtKB/TrEMBL
      Q3TVL4
    4. NM_001428613.1NP_001415542.1  E3 ubiquitin-protein ligase Mdm2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC132139
      UniProtKB/TrEMBL
      Q3TVL4
    5. NM_001428614.1NP_001415543.1  E3 ubiquitin-protein ligase Mdm2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC132139
      UniProtKB/TrEMBL
      Q3TVL4
    6. NM_001428615.1NP_001415544.1  E3 ubiquitin-protein ligase Mdm2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC132139
      UniProtKB/TrEMBL
      Q3TVL4
    7. NM_001428616.1NP_001415545.1  E3 ubiquitin-protein ligase Mdm2 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8), as well as variant 9, encodes isoform 3.
      Source sequence(s)
      AC132139
    8. NM_001428617.1NP_001415546.1  E3 ubiquitin-protein ligase Mdm2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC132139
    9. NM_010786.5NP_034916.1  E3 ubiquitin-protein ligase Mdm2 isoform 1

      See identical proteins and their annotated locations for NP_034916.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC132139
      Consensus CDS
      CCDS24194.1
      UniProtKB/Swiss-Prot
      P23804, Q61040, Q64330, Q91XK7
      UniProtKB/TrEMBL
      Q3TVL4
      Related
      ENSMUSP00000020408.9, ENSMUST00000020408.16
      Conserved Domains (3) summary
      pfam00641
      Location:297326
      zf-RanBP; Zn-finger in Ran binding protein and others
      pfam02201
      Location:4692
      SWIB; SWIB/MDM2 domain
      pfam13920
      Location:434481
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

    RNA

    1. NR_190427.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC132139

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      117524780..117546663 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155661.1XP_036011554.1  E3 ubiquitin-protein ligase Mdm2 isoform X1

      Conserved Domains (3) summary
      cd16783
      Location:384439
      mRING-HC-C2H2C4_MDM2; Modified RING finger, HC subclass (C2H2C4-type), found in E3 ubiquitin-protein ligase MDM2 and similar proteins
      pfam00641
      Location:248277
      zf-RanBP; Zn-finger in Ran binding protein and others
      cl38907
      Location:158
      SWIB-MDM2; SWIB/MDM2 domain family
    2. XM_017313822.2XP_017169311.1  E3 ubiquitin-protein ligase Mdm2 isoform X2

      Conserved Domains (2) summary
      cd16783
      Location:236291
      mRING-HC-C2H2C4_MDM2; Modified RING finger, HC subclass (C2H2C4-type), found in E3 ubiquitin-protein ligase MDM2 and similar proteins
      pfam00641
      Location:101129
      zf-RanBP; Zn-finger in Ran binding protein and others
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