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    Rbbp7 retinoblastoma binding protein 7, chromatin remodeling factor [ Mus musculus (house mouse) ]

    Gene ID: 245688, updated on 4-Jan-2025

    Summary

    Official Symbol
    Rbbp7provided by MGI
    Official Full Name
    retinoblastoma binding protein 7, chromatin remodeling factorprovided by MGI
    Primary source
    MGI:MGI:1194910
    See related
    Ensembl:ENSMUSG00000031353 AllianceGenome:MGI:1194910
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mRbAp46
    Summary
    Enables RNA binding activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleus. Part of ESC/E(Z) complex and NuRD complex. Is expressed in several structures, including brain; early conceptus; genitourinary system; hemolymphoid system; and submandibular gland primordium. Orthologous to human RBBP7 (RB binding protein 7, chromatin remodeling factor). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Broad expression in placenta adult (RPKM 217.3), liver E18 (RPKM 180.1) and 21 other tissues See more
    Orthologs
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    Genomic context

    See Rbbp7 in Genome Data Viewer
    Location:
    X F4; X 74.97 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (161543368..161562086)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (162760372..162779090)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_48212 Neighboring gene predicted gene 15201 Neighboring gene STARR-seq mESC enhancer starr_48213 Neighboring gene STARR-seq mESC enhancer starr_48214 Neighboring gene predicted gene, 23786 Neighboring gene STARR-seq mESC enhancer starr_48215 Neighboring gene STARR-seq mESC enhancer starr_48217 Neighboring gene taxilin gamma Neighboring gene STARR-positive B cell enhancer mm9_chrX:159267245-159267546 Neighboring gene STARR-seq mESC enhancer starr_48218 Neighboring gene pyruvate kinase, muscle pseudogene Neighboring gene predicted gene, 23901

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Gene trapped (1) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding PubMed 
    enables histone binding  
    enables histone binding  
    enables histone binding  
    enables protein binding PubMed 
    Process Evidence Code Pubs
    involved_in DNA replication  
    involved_in brain development PubMed 
    involved_in cellular heat acclimation  
    involved_in cellular heat acclimation PubMed 
    involved_in chromatin remodeling  
    involved_in chromatin remodeling  
    acts_upstream_of_or_within chromatin remodeling PubMed 
    acts_upstream_of_or_within negative regulation of DNA-templated transcription PubMed 
    involved_in negative regulation of DNA-templated transcription PubMed 
    involved_in negative regulation of cell growth  
    involved_in negative regulation of cell growth  
    involved_in negative regulation of cell migration PubMed 
    involved_in negative regulation of stem cell population maintenance PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II PubMed 
    involved_in negative regulation of transcription by RNA polymerase II PubMed 
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway PubMed 
    involved_in positive regulation of DNA-templated transcription PubMed 
    involved_in positive regulation of stem cell population maintenance PubMed 
    involved_in regulation of DNA-templated transcription  
    involved_in regulation of DNA-templated transcription  
    involved_in regulation of cell fate specification PubMed 
    involved_in regulation of stem cell differentiation PubMed 
    involved_in response to steroid hormone  
    Items 1 - 20 of 23
    Component Evidence Code Pubs
    part_of ATPase complex  
    part_of ESC/E(Z) complex  
    part_of ESC/E(Z) complex PubMed 
    part_of ESC/E(Z) complex  
    part_of ESC/E(Z) complex  
    part_of NURF complex  
    part_of NuRD complex  
    part_of NuRD complex PubMed 
    part_of NuRD complex  
    part_of NuRD complex  
    part_of NuRD complex PubMed 
    part_of Sin3-type complex PubMed 
    located_in chromosome, telomeric region  
    located_in chromosome, telomeric region  
    located_in cytosol  
    located_in cytosol  
    part_of histone deacetylase complex  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in nucleus  
    located_in nucleus PubMed 
    Items 1 - 20 of 23

    General protein information

    Preferred Names
    histone-binding protein RBBP7
    Names
    G1/S transition control protein-binding protein
    RBBP-7
    histone acetyltransferase type B subunit 2
    nucleosome-remodeling factor subunit RBAP46
    retinoblastoma-binding protein 7
    retinoblastoma-binding protein p46

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009031.3NP_033057.3  histone-binding protein RBBP7

      See identical proteins and their annotated locations for NP_033057.3

      Status: VALIDATED

      Source sequence(s)
      AK078349, AK135779, CA556887
      Consensus CDS
      CCDS30509.1
      UniProtKB/Swiss-Prot
      A2AFJ0, Q3UX20, Q60973
      UniProtKB/TrEMBL
      Q3UJI2, Q8C5H3
      Related
      ENSMUSP00000033720.6, ENSMUST00000033720.12
      Conserved Domains (3) summary
      sd00039
      Location:127174
      7WD40; WD40 repeat [structural motif]
      pfam12265
      Location:1887
      CAF1C_H4-bd; Histone-binding protein RBBP4 or subunit C of CAF1 complex
      cl29593
      Location:122402
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      161543368..161562086
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030251353.1XP_030107213.1  histone-binding protein RBBP7 isoform X1

      UniProtKB/TrEMBL
      Q3UJI2, Q3UX53, Q8C5H3
      Conserved Domains (3) summary
      sd00039
      Location:93140
      7WD40; WD40 repeat [structural motif]
      pfam12265
      Location:153
      CAF1C_H4-bd; Histone-binding protein RBBP4 or subunit C of CAF1 complex
      cl29593
      Location:88368
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
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