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    ADAM1A ADAM metallopeptidase domain 1A (pseudogene) [ Homo sapiens (human) ]

    Gene ID: 8759, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ADAM1Aprovided by HGNC
    Official Full Name
    ADAM metallopeptidase domain 1A (pseudogene)provided by HGNC
    Primary source
    HGNC:HGNC:187
    See related
    AllianceGenome:HGNC:187
    Gene type
    pseudo
    RefSeq status
    INFERRED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Ftna; ADAM1; FTNAP; ADAM1P; PH-30a
    Summary
    Predicted to act upstream of or within binding activity of sperm to zona pellucida. Predicted to be located in membrane raft. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ADAM1A in Genome Data Viewer
    Location:
    12q24.12-q24.13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (111899063..111901902)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (111875972..111878811)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (112336867..112339706)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene MAPKAPK5 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7040 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4876 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4877 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7041 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:112282209-112282377 Neighboring gene MAPK activated protein kinase 5 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:112292092-112292249 Neighboring gene ribosomal protein S2 pseudogene 41 Neighboring gene ADAM metallopeptidase domain 1B (pseudogene) Neighboring gene transmembrane protein 116 Neighboring gene MPRA-validated peak1957 silencer Neighboring gene MPRA-validated peak1958 silencer Neighboring gene Sharpr-MPRA regulatory region 5697 Neighboring gene solute carrier family 25 member 3 pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The human fertilin alpha gene is non-functional: implications for its proposed role in fertilization. Jury JA, et al. Biochem J, 1997 Feb 1. PMID 9032439, Free PMC Article
    2. Calmegin is required for fertilin alpha/beta heterodimerization and sperm fertility. Ikawa M, et al. Dev Biol, 2001 Dec 1. PMID 11784061
    3. The identification of seven metalloproteinase-disintegrin (ADAM) genes from genomic libraries. Poindexter K, et al. Gene, 1999 Sep 3. PMID 10524237
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Other Names

    • ADAM metallopeptidase domain 1 (fertilin alpha) pseudogene
    • ADAM metallopeptidase domain 1, pseudogene
    • a disintegrin and metalloproteinase domain 1 ( fertilin alpha)
    • a disintegrin and metalloproteinase domain 1 (fertilin alpha) pseudogene
    • fertilin alpha

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_065830.1 

      Range
      101..2940
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      111899063..111901902
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      111875972..111878811
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NG_001216.2: Suppressed sequence

      Description
      NG_001216.2: This RefSeq was permanently suppressed because it is now thought that this gene is a transcribed pseudogene rather than a non-transcribed pseudogene and should be represented by an NR_ accession prefix rather than an NG_ accession prefix.

    2. NG_024128.1: Suppressed sequence

      Description
      NG_024128.1: This RefSeq was permanently suppressed because it is now thought that this pseudogene is transcribed.

    3. NR_036636.1: Suppressed sequence

      Description
      NR_036636.1: This RefSeq was removed because there is insufficient evidence that this locus is transcribed.
    Nucleotide Protein
    Heading Accession and Version

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