Eif5a eukaryotic translation initiation factor 5A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Eif5aprovided by RGD
Official Full Name: eukaryotic translation initiation factor 5Aprovided by RGD
Primary source: RGD:1308029
See related: AllianceGenome:RGD:1308029
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable U6 snRNA binding activity and translation elongation factor activity. Involved in several processes, including cellular response to thyroid hormone stimulus; positive regulation of reactive oxygen species metabolic process; and regulation of apoptotic process. Located in dendrite and neuronal cell body. Is active in synapse. Orthologous to several human genes including EIF5A (eukaryotic translation initiation factor 5A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 666.5), Spleen (RPKM 641.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q24

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (55138821..55143272, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (54640104..54644845, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (56527075..56531615, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Role of eIF5A1 in LPS-Induced Neuronal Remodeling of the Nucleus Accumbens in the Depression.
Title: The Role of eIF5A1 in LPS-Induced Neuronal Remodeling of the Nucleus Accumbens in the Depression.
The results of this study support the notion that by inhibiting eIF5A hypusination, FSH reduces the expression of an LHCGR mRNA-binding protein (LRBP), and then this increases LHCGR mRNA expression by abrogating the inhibitory action of LRBP.
Title: LHCGR Expression During Follicle Stimulating Hormone-Induced Follicle Growth Is Negatively Regulated by Eukaryotic Initiation Factor 5A.
Overexpression or knockdown of miR-434-3p in vivo demonstrated it was a negative post-transcriptional regulator of eIF5A1 expression and influenced AChRs expression.
Title: miR-434-3p and DNA hypomethylation co-regulate eIF5A1 to increase AChRs and to improve plasticity in SCT rat skeletal muscle.
secretion of ORAIP in response to oxidative stress is universal mechanism and plays an essential role. ORAIP will be an important novel biomarker as well as a specific therapeutic target of these oxidative stress-induced cell injuries.
Title: Plasma levels of oxidative stress-responsive apoptosis inducing protein (ORAIP) in rats subjected to physicochemical oxidative stresses.
eIF5A1 upregulates RhoGDIalpha to promote neuroplasticity caudal to the spinal cord injury and functional recovery after spinal cord injury.
Title: eIF5A1/RhoGDIα pathway: a novel therapeutic target for treatment of spinal cord injury identified by a proteomics approach.
these results suggest that hCG-induced LHR mRNA downregulation is mediated by cAMP-PKA-ERK1/2 signaling leading to activation of eIF5A hypusination.
Title: Hypusination of eukaryotic initiation factor 5A via cAMP-PKA-ERK1/2 pathway is required for ligand-induced downregulation of LH receptor mRNA expression in the ovary.
eIF-5A1 has a role in the restoration of hindlimb locomotor functions following spinal cord transection
Title: Upregulation of eIF-5A1 in the paralyzed muscle after spinal cord transection associates with spontaneous hindlimb locomotor recovery in rats by upregulation of the ErbB, MAPK and neurotrophin signal pathways.
These results reveal a new physiological role for eIF5A and contribute to elucidate the molecular mechanisms involved in muscle regeneration.
Title: Involvement of eukaryotic translation initiation factor 5A (eIF5A) in skeletal muscle stem cell differentiation.
Data show that eIF5A is present in the whole brain of adult rats showing a variable content and a high content in the soma and dendrites of Purkinje cells.
Title: Insights on eukaryotic translation initiation factor 5A (eIF5A) in the brain and aging.
hypusinated eukaryotic translation initiation factor 5A has a role in polyamine depletion-induced cytostasis
Title: Role of hypusinated eukaryotic translation initiation factor 5A in polyamine depletion-induced cytostasis.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI505953 (e-PCR)
- UniSTS:180235

RH128189 (e-PCR)
- UniSTS:211497

RH125923 (e-PCR)
- UniSTS:162640

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables U6 snRNA binding	ISO Inferred from Sequence Orthology more info
enables ribosome binding	IEA Inferred from Electronic Annotation more info
enables translation elongation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation elongation factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to thyroid hormone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to virus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cardiac muscle cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of reactive oxygen species metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of translational elongation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of translational termination	IEA Inferred from Electronic Annotation more info
involved_in translational elongation	IBA Inferred from Biological aspect of Ancestor more info
involved_in translational elongation	IEA Inferred from Electronic Annotation more info
involved_in translational elongation	ISO Inferred from Sequence Orthology more info
involved_in translational elongation	ISS Inferred from Sequence or Structural Similarity more info
involved_in tumor necrosis factor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in annulate lamellae	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
part_of nuclear pore	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in synapse	EXP Inferred from Experiment more info	PubMed
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: eukaryotic translation initiation factor 5A-1

Names: eIF-4D; eIF-5A; eIF-5A-1; eIF-5A1; eukaryotic initiation factor 5A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033681.2 → NP_001028853.1 eukaryotic translation initiation factor 5A-1

See identical proteins and their annotated locations for NP_001028853.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

Q3T1J1

UniProtKB/TrEMBL

A0A8L2QBS3, A6HFW8

Conserved Domains (1) summary

cl30809
Location:1 → 150

PLN03107; eukaryotic translation initiation factor 5A; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

55138821..55143272 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006246637.5 → XP_006246699.1 eukaryotic translation initiation factor 5A-1 isoform X1

See identical proteins and their annotated locations for XP_006246699.1

UniProtKB/Swiss-Prot

Q3T1J1

UniProtKB/TrEMBL

A0A8L2QBS3, A6HFW8

Conserved Domains (1) summary

cl30809
Location:1 → 150

PLN03107; eukaryotic translation initiation factor 5A; Provisional
XM_006246638.3 → XP_006246700.1 eukaryotic translation initiation factor 5A-1 isoform X1

See identical proteins and their annotated locations for XP_006246700.1

UniProtKB/Swiss-Prot

Q3T1J1

UniProtKB/TrEMBL

A0A8L2QBS3, A6HFW8

Conserved Domains (1) summary

cl30809
Location:1 → 150

PLN03107; eukaryotic translation initiation factor 5A; Provisional
XM_039085461.2 → XP_038941389.1 eukaryotic translation initiation factor 5A-1 isoform X1

UniProtKB/Swiss-Prot

Q3T1J1

UniProtKB/TrEMBL

A0A8L2QBS3, A6HFW8

Conserved Domains (1) summary

cl30809
Location:1 → 150

PLN03107; eukaryotic translation initiation factor 5A; Provisional