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    Fbxl3 F-box and leucine-rich repeat protein 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306129, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fbxl3provided by RGD
    Official Full Name
    F-box and leucine-rich repeat protein 3provided by RGD
    Primary source
    RGD:1305660
    See related
    EnsemblRapid:ENSRNOG00000059334 AllianceGenome:RGD:1305660
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fbxl3a
    Summary
    Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in several processes, including SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; entrainment of circadian clock by photoperiod; and protein destabilization. Predicted to be located in nuclear body. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in cytosol and nucleus. Orthologous to human FBXL3 (F-box and leucine rich repeat protein 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 199.0), Thymus (RPKM 189.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fbxl3 in Genome Data Viewer
    Location:
    15q21
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (86321504..86341387, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (79906795..79926678, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (93647307..93667395, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC108352966 Neighboring gene CLN5, intracellular trafficking protein Neighboring gene MYC binding protein 2 Neighboring gene cytochrome c, somatic pseudogene Neighboring gene uncharacterized LOC108352959

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The after-hours mutant reveals a role for Fbxl3 in determining mammalian circadian period. Godinho SI, et al. Science, 2007 May 11. PMID 17463252
    2. Circadian mutant Overtime reveals F-box protein FBXL3 regulation of cryptochrome and period gene expression. Siepka SM, et al. Cell, 2007 Jun 1. PMID 17462724, Free PMC Article
    3. Distinct and separable roles for endogenous CRY1 and CRY2 within the circadian molecular clockwork of the suprachiasmatic nucleus, as revealed by the Fbxl3(Afh) mutation. Anand SN, et al. J Neurosci, 2013 Apr 24. PMID 23616524, Free PMC Article
    4. Competing E3 ubiquitin ligases govern circadian periodicity by degradation of CRY in nucleus and cytoplasm. Yoo SH, et al. Cell, 2013 Feb 28. PMID 23452855, Free PMC Article
    5. Distinct Roles of HDAC3 in the Core Circadian Negative Feedback Loop Are Critical for Clock Function. Shi G, et al. Cell Rep, 2016 Feb 2. PMID 26776516

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    contributes_to ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in entrainment of circadian clock by photoperiod IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in entrainment of circadian clock by photoperiod ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein destabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of circadian rhythm ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    F-box/LRR-repeat protein 3
    Names
    F-box and leucine-rich repeat protein 3a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100568.1 → NP_001094038.1  F-box/LRR-repeat protein 3

      See identical proteins and their annotated locations for NP_001094038.1

      Status: VALIDATED

      Source sequence(s)
      BC092649, CB718262
      UniProtKB/TrEMBL
      A6HU89, G3V9P4
      Related
      ENSRNOP00000071266.3, ENSRNOT00000089876.3
      Conserved Domains (2) summary
      sd00034
      Location:174 → 199
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:36 → 77
      F-box-like

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      86321504..86341387 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039093401.2 → XP_038949329.1  F-box/LRR-repeat protein 3 isoform X1

      UniProtKB/TrEMBL
      A6HU89, G3V9P4
      Conserved Domains (2) summary
      sd00034
      Location:174 → 199
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:36 → 77
      F-box-like

    2. XM_039093402.2 → XP_038949330.1  F-box/LRR-repeat protein 3 isoform X2

      UniProtKB/TrEMBL
      G3V9P4
      Related
      ENSRNOP00000100094.1, ENSRNOT00000139587.1
      Conserved Domains (2) summary
      sd00034
      Location:133 → 158
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:36 → 77
      F-box-like

    3. XM_006252442.5 → XP_006252504.1  F-box/LRR-repeat protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006252504.1

      UniProtKB/TrEMBL
      A6HU89, G3V9P4
      Related
      ENSRNOP00000104475.1, ENSRNOT00000143708.1
      Conserved Domains (2) summary
      sd00034
      Location:174 → 199
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:36 → 77
      F-box-like
    Nucleotide Protein Strain
    Heading Accession and Version

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