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    Snrpa small nuclear ribonucleoprotein polypeptide A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 292729, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Snrpaprovided by RGD
    Official Full Name
    small nuclear ribonucleoprotein polypeptide Aprovided by RGD
    Primary source
    RGD:1307416
    See related
    EnsemblRapid:ENSRNOG00000001501 AllianceGenome:RGD:1307416
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables U1 snRNP binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Part of U1 snRNP. Human ortholog(s) of this gene implicated in connective tissue disease. Orthologous to human SNRPA (small nuclear ribonucleoprotein polypeptide A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 164.4), Spleen (RPKM 87.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Snrpa in Genome Data Viewer
    Location:
    1q21
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (91609419..91618119, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (82481770..82490540, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (83999670..84008429, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene RAB4B, member RAS oncogene family Neighboring gene MIA SH3 domain containing Neighboring gene actin maturation protease Neighboring gene inositol-trisphosphate 3-kinase C Neighboring gene coenzyme Q8B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of the RNA-binding domain of the U1 small nuclear ribonucleoprotein A. Nagai K, et al. Nature, 1990 Dec 6. PMID 2147232
    2. Post-transcriptional adenylation of signal recognition particle RNA is carried out by an enzyme different from mRNA Poly(A) polymerase. Sinha K, et al. J Biol Chem, 1999 Oct 22. PMID 10521474
    3. U1 small nuclear ribonucleoprotein complex and RNA splicing alterations in Alzheimer's disease. Bai B, et al. Proc Natl Acad Sci U S A, 2013 Oct 8. PMID 24023061, Free PMC Article
    4. The U2 small nuclear ribonucleoprotein particle as an autoantigen. Analysis with sera from patients with overlap syndromes. Craft J, et al. J Clin Invest, 1988 Jun. PMID 2968364, Free PMC Article
    5. Structural analyses of the pre-mRNA splicing machinery. Zhang L, et al. Protein Sci, 2013 Jun. PMID 23592432, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC105915

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables U1 snRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables U1 snRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables U1 snRNP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of U1 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U1 snRNP IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U1 snRNP ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U4/U6 x U5 tri-snRNP complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    U1 small nuclear ribonucleoprotein A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008303.1 → NP_001008304.1  U1 small nuclear ribonucleoprotein A

      See identical proteins and their annotated locations for NP_001008304.1

      Status: PROVISIONAL

      Source sequence(s)
      BC086331
      UniProtKB/TrEMBL
      A0A9K3Y6T2, F1M6Z8, Q5U214
      Related
      ENSRNOP00000002053.5, ENSRNOT00000002053.6
      Conserved Domains (3) summary
      TIGR01628
      Location:12 → 207
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12477
      Location:7 → 95
      RRM1_U1A; RNA recognition motif 1 (RRM1) found in vertebrate U1 small nuclear ribonucleoprotein A (U1A)
      cd12480
      Location:196 → 281
      RRM2_U1A; RNA recognition motif 2 (RRM2) found in vertebrate U1 small nuclear ribonucleoprotein A (U1 snRNP A or U1-A or U1A)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      91609419..91618119 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006228564.5 → XP_006228626.1  U1 small nuclear ribonucleoprotein A isoform X1

      See identical proteins and their annotated locations for XP_006228626.1

      UniProtKB/TrEMBL
      A0A9K3Y6T2, F1M6Z8, Q5U214
      Conserved Domains (3) summary
      TIGR01628
      Location:12 → 207
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12477
      Location:7 → 95
      RRM1_U1A; RNA recognition motif 1 (RRM1) found in vertebrate U1 small nuclear ribonucleoprotein A (U1A)
      cd12480
      Location:196 → 281
      RRM2_U1A; RNA recognition motif 2 (RRM2) found in vertebrate U1 small nuclear ribonucleoprotein A (U1 snRNP A or U1-A or U1A)
    Nucleotide Protein Strain
    Heading Accession and Version

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