Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hsd11b1provided by RGD
Official Full Name: hydroxysteroid 11-beta dehydrogenase 1provided by RGD
Primary source: RGD:2834
See related: EnsemblRapid:ENSRNOG00000005861 AllianceGenome:RGD:2834
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: LRRGT00065
Summary: Enables NADP binding activity and steroid binding activity. Involved in several processes, including cellular response to estradiol stimulus; glucocorticoid metabolic process; and regulation of pentose-phosphate shunt. Located in apical part of cell and nuclear membrane. Used to study obesity. Biomarker of familial hyperlipidemia; status epilepticus; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in cortisone reductase deficiency (multiple); hypertension (multiple); and type 2 diabetes mellitus. Orthologous to human HSD11B1 (hydroxysteroid 11-beta dehydrogenase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 1885.5), Kidney (RPKM 1094.3) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q27

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (107277526..107327462, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (104728539..104798884, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (111946626..111996536, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

beta-Adrenergic Stimulation-Induced PVAT Dysfunction in Male Sex: A Role for 11beta-Hydroxysteroid Dehydrogenase-1.
Title: β-Adrenergic Stimulation-Induced PVAT Dysfunction in Male Sex: A Role for 11β-Hydroxysteroid Dehydrogenase-1.
Memory deficits in a juvenile rat model of type 1 diabetes are due to excess 11beta-HSD1 activity, which is upregulated by high glucose concentrations rather than insulin deficiency.
Title: Memory deficits in a juvenile rat model of type 1 diabetes are due to excess 11β-HSD1 activity, which is upregulated by high glucose concentrations rather than insulin deficiency.
The Link between Activities of Hepatic 11beta-Hydroxysteroid Dehydrogenase-1 and Monoamine Oxidase-A in the Brain Following Repeated Predator Stress: Focus on Heightened Anxiety.
Title: The Link between Activities of Hepatic 11beta-Hydroxysteroid Dehydrogenase-1 and Monoamine Oxidase-A in the Brain Following Repeated Predator Stress: Focus on Heightened Anxiety.
Addressing the role of 11beta-hydroxysteroid dehydrogenase type 1 in the development of polycystic ovary syndrome and the putative therapeutic effects of its selective inhibition in a preclinical model.
Title: Addressing the role of 11β-hydroxysteroid dehydrogenase type 1 in the development of polycystic ovary syndrome and the putative therapeutic effects of its selective inhibition in a preclinical model.
These findings indicated that 11beta-HSD1 inhibition can give a potential benefit in reducing obesity and lowering insulin resistance by modulating the insulin-signaling pathway and adipocytokine production.
Title: Inhibition of 11β-hydroxysteroid dehydrogenase type 1 ameliorates obesity-related insulin resistance.
the high-sucrose intake in stressed rats (St + S30 group) reduced the hepatic 11beta-HSD-1 activity, the level of serum corticosterone, and the hepatic triacylglycerol content
Title: High Sucrose Intake Ameliorates the Accumulation of Hepatic Triacylglycerol Promoted by Restraint Stress in Young Rats.
the availability of H6PDH determines the different direction of 11beta-HSD1 in liver and Leydig cells.
Title: Metabolic Coupling Determines the Activity: Comparison of 11β-Hydroxysteroid Dehydrogenase 1 and Its Coupling between Liver Parenchymal Cells and Testicular Leydig Cells.
The enzyme activity increased 3-4 fold in the adrenal glands throughout the month-long development of alloxan diabetes.
Title: Activity of 11β-hydroxysteroid dehydrogenase in the adrenal glands, liver, and kidneys of rats with experimental diabetes.
Depending on the rat strain, stress stimulates 11HSD1 in the ventral hippocampus.
Title: Distinct effect of stress on 11beta-hydroxysteroid dehydrogenase type 1 and corticosteroid receptors in dorsal and ventral hippocampus.
the presented data clearly suggest a role of 11HSD1 in modulation of glucocorticoid feedback of the HPA axis during stress.
Title: Regulation of 11β-hydroxysteroid dehydrogenase type 1 and 7α-hydroxylase CYP7B1 during social stress.

Submit: New GeneRIF Correction See all GeneRIFs (55)

General gene information

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Markers

RH128149 (e-PCR)
- UniSTS:211457

AU048742 (e-PCR)
- UniSTS:145192

px-34e1 (e-PCR)
- UniSTS:257617

px-21d9 (e-PCR)
- UniSTS:257397

X83202 (e-PCR)
- UniSTS:178555

px-38b5 (e-PCR)
- UniSTS:257691

D13Wox22 (e-PCR)
- UniSTS:240613

MARC_17267-17268:1024684507:1 (e-PCR)
- UniSTS:268272

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 11-beta-hydroxysteroid dehydrogenase (NADP+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables 11-beta-hydroxysteroid dehydrogenase (NADP+) activity	ISO Inferred from Sequence Orthology more info
enables 7-beta-hydroxysteroid dehydrogenase (NADP+) activity	IEA Inferred from Electronic Annotation more info
enables NADP binding	IDA Inferred from Direct Assay more info	PubMed
enables NADP binding	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables steroid binding	IBA Inferred from Biological aspect of Ancestor more info
enables steroid binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to estradiol stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in glucocorticoid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glucocorticoid catabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within lung development	ISO Inferred from Sequence Orthology more info
involved_in mineralocorticoid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of pentose-phosphate shunt	IDA Inferred from Direct Assay more info	PubMed
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed
involved_in steroid catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: 11-beta-hydroxysteroid dehydrogenase 1

Names: 11-DH; 11-beta-HSD1; 11-beta-hydroxysteroid dehydrogenase, type 1; 11beta-HSD1; 7-oxosteroid reductase; corticosteroid 11-beta-dehydrogenase isozyme 1; cortocosteroid 11-beta dehydrogenase; hydroxysteroid dehydrogenase, 11 beta type 1

NP_058776.2

EC 1.1.1.146

EC 1.1.1.201

XP_006250535.1

EC 1.1.1.146

EC 1.1.1.201

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001429463.1 → NP_001416392.1 11-beta-hydroxysteroid dehydrogenase 1 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/Swiss-Prot

O09170, P16232, Q6LDH6

UniProtKB/TrEMBL

A0A8I6GHA3, A6JH26
NM_001429464.1 → NP_001416393.1 11-beta-hydroxysteroid dehydrogenase 1 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/TrEMBL

A0A8I6GHA3
NM_001429465.1 → NP_001416394.1 11-beta-hydroxysteroid dehydrogenase 1 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/Swiss-Prot

O09170, P16232, Q6LDH6

UniProtKB/TrEMBL

A0A8I6GHA3, A6JH26
NM_017080.2 → NP_058776.2 11-beta-hydroxysteroid dehydrogenase 1 isoform 1

See identical proteins and their annotated locations for NP_058776.2

Status: VALIDATED

Source sequence(s)

BC078865, CK474613

UniProtKB/Swiss-Prot

O09170, P16232, Q6LDH6

UniProtKB/TrEMBL

A0A8I6GHA3, A6JH26

Conserved Domains (1) summary

cd05332
Location:28 → 275

11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

107277526..107327462 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006250473.5 → XP_006250535.1 11-beta-hydroxysteroid dehydrogenase 1 isoform X1

Related

ENSRNOP00000089436.1, ENSRNOT00000116672.2

Conserved Domains (1) summary

cd05332
Location:28 → 275

11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs