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    Cdca4 cell division cycle associated 4 [ Mus musculus (house mouse) ]

    Gene ID: 71963, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cdca4provided by MGI
    Official Full Name
    cell division cycle associated 4provided by MGI
    Primary source
    MGI:MGI:1919213
    See related
    Ensembl:ENSMUSG00000047832 AllianceGenome:MGI:1919213
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HEPP; SEI-3; 2410018C03Rik
    Summary
    Predicted to enable transcription coactivator activity. Located in nucleus. Is expressed in several structures, including alimentary system; brain; branchial arch; neural ectoderm; and sensory organ. Orthologous to human CDCA4 (cell division cycle associated 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 31.9), CNS E11.5 (RPKM 24.0) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cdca4 in Genome Data Viewer
    Location:
    12 F1; 12 61.2 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (112783849..112793141, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (112820229..112829521, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene AHNAK nucleoprotein 2 Neighboring gene clathrin binding box of aftiphilin containing 1 Neighboring gene STARR-seq mESC enhancer starr_33365 Neighboring gene STARR-seq mESC enhancer starr_33367 Neighboring gene predicted gene, 52009 Neighboring gene STARR-seq mESC enhancer starr_33369 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:114093201-114093409 Neighboring gene G protein-coupled receptor 132 Neighboring gene predicted gene, 30461 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:114108177-114108360 Neighboring gene RIKEN cDNA 1700127F24 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Evolutionary conservation and murine embryonic expression of the gene encoding the SERTA domain-containing protein CDCA4 (HEPP). Bennetts JS, et al. Gene, 2006 Jun 7. PMID 16546331
    2. Cloning and characterization of Hepp, a novel gene expressed preferentially in hematopoietic progenitors and mature blood cells. Abdullah JM, et al. Blood Cells Mol Dis, 2001 May-Jun. PMID 11482882
    3. ALKBH5 promotes the development of lung adenocarcinoma by regulating the polarization of M2 macrophages through CDCA4. Tan J, et al. Gene, 2024 Feb 15. PMID 37949419
    4. Sertad1 encodes a novel transcriptional co-activator of SMAD1 in mouse embryonic hearts. Peng Y, et al. Biochem Biophys Res Commun, 2013 Nov 29. PMID 24211589, Free PMC Article
    5. SEI family of nuclear factors regulates p53-dependent transcriptional activation. Watanabe-Fukunaga R, et al. Genes Cells, 2005 Aug. PMID 16098148

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ALKBH5 promotes the development of lung adenocarcinoma by regulating the polarization of M2 macrophages through CDCA4.
      Title: ALKBH5 promotes the development of lung adenocarcinoma by regulating the polarization of M2 macrophages through CDCA4.
    2. The evolutionary conservation and murine embryonic expression of the gene encoding the SERTA domain-containing protein Cdca4 was studied.
      Title: Evolutionary conservation and murine embryonic expression of the gene encoding the SERTA domain-containing protein CDCA4 (HEPP).
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Homology

    Clone Names

    • 2410018C03Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cell division cycle-associated protein 4
    Names
    hematopoietic progenitor protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359234.1 → NP_001346163.1  cell division cycle-associated protein 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the shortest transcript. All variants encode the same protein.
      Source sequence(s)
      AF322238, AK010535, BY199153
      Consensus CDS
      CCDS26198.1
      UniProtKB/Swiss-Prot
      Q3U1C0, Q921E8, Q99MP6, Q9CWM2
      UniProtKB/TrEMBL
      Q3USY8
      Related
      ENSMUSP00000152315.2, ENSMUST00000220899.2
      Conserved Domains (1) summary
      pfam06031
      Location:33 → 68
      SERTA; SERTA motif

    2. NM_001359292.1 → NP_001346221.1  cell division cycle-associated protein 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 2. All variants encode the same protein.
      Source sequence(s)
      AC160929, AF322238, BY201887
      Consensus CDS
      CCDS26198.1
      UniProtKB/Swiss-Prot
      Q3U1C0, Q921E8, Q99MP6, Q9CWM2
      UniProtKB/TrEMBL
      Q3USY8
      Conserved Domains (1) summary
      pfam06031
      Location:33 → 68
      SERTA; SERTA motif

    3. NM_028023.4 → NP_082299.1  cell division cycle-associated protein 4

      See identical proteins and their annotated locations for NP_082299.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 2. All variants encode the same protein.
      Source sequence(s)
      AC160929, AF322238
      Consensus CDS
      CCDS26198.1
      UniProtKB/Swiss-Prot
      Q3U1C0, Q921E8, Q99MP6, Q9CWM2
      UniProtKB/TrEMBL
      Q3USY8
      Related
      ENSMUSP00000058901.6, ENSMUST00000062092.7
      Conserved Domains (1) summary
      pfam06031
      Location:33 → 68
      SERTA; SERTA motif

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      112783849..112793141 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CWM2.2 GenPept UniProtKB/Swiss-Prot:Q9CWM2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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