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    Ssh3 slingshot protein phosphatase 3 [ Mus musculus (house mouse) ]

    Gene ID: 245857, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ssh3provided by MGI
    Official Full Name
    slingshot protein phosphatase 3provided by MGI
    Primary source
    MGI:MGI:2683546
    See related
    Ensembl:ENSMUSG00000034616 AllianceGenome:MGI:2683546
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SSH-3; SSH-3L
    Summary
    Predicted to enable actin binding activity and phosphoprotein phosphatase activity. Predicted to be involved in actin cytoskeleton organization and negative regulation of actin filament polymerization. Predicted to be located in cytoskeleton and nucleus. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and skin. Orthologous to human SSH3 (slingshot protein phosphatase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in colon adult (RPKM 50.6), large intestine adult (RPKM 32.3) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ssh3 in Genome Data Viewer
    Location:
    19 A; 19 3.96 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (4311696..4319261, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (4261668..4269233, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1500032F14 gene Neighboring gene STARR-positive B cell enhancer ABC_E11667 Neighboring gene predicted gene, 45928 Neighboring gene cardiotrophin-like cytokine factor 1 Neighboring gene STARR-positive B cell enhancer ABC_E969 Neighboring gene polymerase (DNA-directed), delta 4 Neighboring gene STARR-positive B cell enhancer ABC_E5676 Neighboring gene microRNA 6985 Neighboring gene ankyrin repeat domain 13 family, member D Neighboring gene STARR-positive B cell enhancer ABC_E5677 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:4294334-4294632 Neighboring gene G protein-coupled receptor kinase 2 Neighboring gene STARR-positive B cell enhancer ABC_E7626 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:4302085-4302194 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:4302330-4302483 Neighboring gene STARR-positive B cell enhancer ABC_E9988

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Slingshot-3 dephosphorylates ADF/cofilin but is dispensable for mouse development. Kousaka K, et al. Genesis, 2008 May. PMID 18442045
    2. Differential activities, subcellular distribution and tissue expression patterns of three members of Slingshot family phosphatases that dephosphorylate cofilin. Ohta Y, et al. Genes Cells, 2003 Oct. PMID 14531860
    3. Coordination of Cellular Dynamics Contributes to Tooth Epithelium Deformations. Morita R, et al. PLoS One, 2016. PMID 27588418, Free PMC Article
    4. Toxic gain of function from mutant FUS protein is crucial to trigger cell autonomous motor neuron loss. Scekic-Zahirovic J, et al. EMBO J, 2016 May 17. PMID 26951610, Free PMC Article
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables MAP kinase serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin-dependent protein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS140 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXY142 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity, metal-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of actin filament polymerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein phosphatase Slingshot homolog 3
    Names
    SSH-like protein 3
    slingshot homolog 3
    slingshot-3L
    slingshot-like 3
    NP_001343549.1
    NP_001361616.1
    NP_932781.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356620.1 → NP_001343549.1  protein phosphatase Slingshot homolog 3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate, in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC140073
      Consensus CDS
      CCDS89300.1
      UniProtKB/TrEMBL
      A0A498WGL8
      Related
      ENSMUSP00000109483.6, ENSMUST00000113852.6
      Conserved Domains (3) summary
      cd11652
      Location:3 → 255
      SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
      cd00127
      Location:325 → 460
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
      pfam08766
      Location:268 → 319
      DEK_C; DEK C terminal domain

    2. NM_001374687.1 → NP_001361616.1  protein phosphatase Slingshot homolog 3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AB099289, AC140073, AK149880
      Related
      ENSMUSP00000158486.2, ENSMUST00000236794.2
      Conserved Domains (3) summary
      cd11652
      Location:3 → 256
      SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
      cd14571
      Location:327 → 470
      DSP_slingshot_3; dual specificity phosphatase domain of slingshot homolog 3
      pfam08766
      Location:273 → 324
      DEK_C; DEK C terminal domain

    3. NM_198113.3 → NP_932781.1  protein phosphatase Slingshot homolog 3 isoform 1

      See identical proteins and their annotated locations for NP_932781.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1)
      Source sequence(s)
      AC140073, AK148293, AK164662, AW060821, BE864347
      Consensus CDS
      CCDS29425.1
      UniProtKB/Swiss-Prot
      Q3UDX0, Q8K330
      Related
      ENSMUSP00000047718.9, ENSMUST00000037992.16
      Conserved Domains (3) summary
      cd11652
      Location:3 → 256
      SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
      cd00127
      Location:326 → 461
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
      pfam08766
      Location:269 → 317
      DEK_C; DEK C terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      4311696..4319261 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K330.1 GenPept UniProtKB/Swiss-Prot:Q8K330

    Gene LinkOut

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