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    ascG DNA-binding transcriptional repressor AscG [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947305, updated on 3-Dec-2024

    Summary

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    Official Symbol
    ascG
    Official Full Name
    DNA-binding transcriptional repressor AscG
    Primary source
    ECOCYC:EG10087
    Locus tag
    b2714
    See related
    ASAP:ABE-0008922
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2709; sac
    Summary
    The AscG, "arbutin-salicin-cellibiose," transcriptional regulator represses the expression of a cryptic operon (ascFB) whose genes are involved in transport and utilization of the -glucoside sugars arbutin, salicin, and cellibiose. [More information is available at EcoCyc: EG10087].
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    Genomic context

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    Sequence:
    NC_000913.3 (2838254..2839264, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene carbamoyl--[HypE] ligase Neighboring gene putative electron transport protein HydN Neighboring gene beta-glucoside specific PTS enzyme IIBC component Neighboring gene 6-phospho-beta-glucosidase AscB

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Participation of regulator AscG of the beta-glucoside utilization operon in regulation of the propionate catabolism operon. Ishida Y, et al. J Bacteriol, 2009 Oct. PMID 19633077, Free PMC Article
    2. Deletion analysis of the Escherichia coli ara PC and PBAD promoters. Dunn TM, et al. J Mol Biol, 1984 Nov 25. PMID 6392566
    3. Physical map location of the asc (formerly sac) operon of Escherichia coli K-12. Hall BG, et al. J Bacteriol, 1991 Sep. PMID 1885507, Free PMC Article
    4. A fourth Escherichia coli gene system with the potential to evolve beta-glucoside utilization. Parker LL, et al. Genetics, 1988 Jul. PMID 3042507, Free PMC Article
    5. Nucleotide sequence, function, activation, and evolution of the cryptic asc operon of Escherichia coli K12. Hall BG, et al. Mol Biol Evol, 1992 Jul. PMID 1630307

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA-templated transcription IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA-binding transcriptional repressor AscG

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2838254..2839264 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417194.2 DNA-binding transcriptional repressor AscG [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417194.2

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A024L9P8, A0A895P488
      Conserved Domains (2) summary
      smart00354
      Location:2 → 69
      HTH_LACI; helix_turn _helix lactose operon repressor
      cd06270
      Location:61 → 329
      PBP1_GalS-like; ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism
    Nucleotide Protein
    Heading Accession and Version

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