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    uxuB D-mannonate oxidoreductase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946795, updated on 3-Dec-2024

    Summary

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    Official Symbol
    uxuB
    Official Full Name
    D-mannonate oxidoreductase
    Primary source
    ECOCYC:EG20248
    Locus tag
    b4323
    See related
    ASAP:ABE-0014175
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4314
    Summary
    UxuR regulon. [More information is available at EcoGene: EG20248]. D-mannonate oxidoreductase is an enzyme of the D-glucuronate degradation pathway, reducing D-fructuronate to D-mannonate. [More information is available at EcoCyc: EG20248].
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    Genomic context

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    Sequence:
    NC_000913.3 (4552901..4554361)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene fructuronate transporter Neighboring gene D-mannonate dehydratase Neighboring gene DNA-binding transcriptional repressor UxuR Neighboring gene DUF2686 domain-containing protein YjiC

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. [Studies of mutations in glucuronate catabolism in Escherichia coli K12 (author's transl)]. Robert-Baudouy JM, et al. Mol Gen Genet, 1974. PMID 4603847
    2. [D-mannonate: NAD oxidoreductase from Escherichia coli K12. Purification, properties and specificity]. Portalier RC, et al. Eur J Biochem, 1972 Mar 27. PMID 4402996
    3. [D-mannonate: NAD-oxidoreductase from Escherichia coli K12. Kinetic studies of the enzymatic mechanism]. Portalier RC. Eur J Biochem, 1972 Oct. PMID 4351435
    4. "Hit-and-run" mechanism for D-glucuronate reduction catalyzed by D-mannonate:NAD oxidoreductase of Escherichia coli. Mandrand-Berthelot MA, et al. Biochim Biophys Acta, 1977 Jul 8. PMID 195622
    5. Uronic acid metabolism in bacteria. II. Purification and properties of D-altronic acid and D-mannonic acid dehydrogenases in Escherichia coli. HICKMAN J, et al. J Biol Chem, 1960 Jun. PMID 14401695

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables fructuronate reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fructuronate reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fructuronate reductase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in D-glucuronate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within D-glucuronate catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mannitol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    D-mannonate oxidoreductase
    NP_418743.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4552901..4554361
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418743.1 D-mannonate oxidoreductase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418743.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376MCY8, A0A8S7EHN5
      Conserved Domains (1) summary
      PRK15037
      Location:1 → 486
      PRK15037; D-mannonate oxidoreductase; Provisional
    Nucleotide Protein
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