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    recX RecA inhibitor RecX [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947172, updated on 17-Dec-2024

    Summary

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    Official Symbol
    recX
    Official Full Name
    RecA inhibitor RecX
    Primary source
    ECOCYC:EG12080
    Locus tag
    b2698
    See related
    ASAP:ABE-0008872
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2693; oraA
    Summary
    RecX (negative) directly competes with DinI (positive) as modulators of RecA function. lexA regulon. [More information is available at EcoGene: EG12080]. RecX associates with RecA and inhibits RecA ATP hydrolysis, coprotease, and DNA strand exchange activities . [More information is available at EcoCyc: EG12080].
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    Genomic context

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    Sequence:
    NC_000913.3 (2822139..2822639, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene carbon storage regulator Neighboring gene alanine--tRNA ligase/DNA-binding transcriptional repressor Neighboring gene DNA recombination/repair protein RecA Neighboring gene NMN aminohydrolase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nucleotide sequence between recA and alaSp in E. coli K12 and the sequence change in four recA mutations. Zaitsev E, et al. Mutat Res, 1994 Apr. PMID 7512687
    2. Tryptophanase in sRNA control of the Escherichia coli cell cycle. Chattoraj DK. Mol Microbiol, 2007 Jan. PMID 17163965
    3. Differential cross-complementation patterns of Escherichia coli and Neisseria gonorrhoeae RecA proteins. Stohl EA, et al. Microbiology (Reading), 2002 Jun. PMID 12055302
    4. Escherichia coli RecX inhibits RecA recombinase and coprotease activities in vitro and in vivo. Stohl EA, et al. J Biol Chem, 2003 Jan 24. PMID 12427742
    5. DinI and RecX modulate RecA-DNA structures in Escherichia coli K-12. Renzette N, et al. Mol Microbiol, 2007 Jan. PMID 17163974

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The combination of RecX and UvrD are required for suppression of constitutive SOS expression by RecA.
      Title: Suppression of constitutive SOS expression by recA4162 (I298V) and recA4164 (L126V) requires UvrD and RecX in Escherichia coli K-12.
    2. there is a C-terminal point mutation in RecA protein (E343K) that significantly alters the interaction between RecA and RecX proteins
      Title: Inhibition of RecA protein by the Escherichia coli RecX protein: modulation by the RecA C terminus and filament functional state.
    3. DinI and RecX are competing modulators of RecA function
      Title: The DinI and RecX proteins are competing modulators of RecA function.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in SOS response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within SOS response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in regulation of DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RecA inhibitor RecX

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2822139..2822639 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417178.1 RecA inhibitor RecX [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417178.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7EGA1
      Conserved Domains (1) summary
      PRK00117
      Location:3 → 166
      recX; recombination regulator RecX; Reviewed
    Nucleotide Protein
    Heading Accession and Version

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