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    gmhA D-sedoheptulose 7-phosphate isomerase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 949134, updated on 17-Dec-2024

    Summary

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    Official Symbol
    gmhA
    Official Full Name
    D-sedoheptulose 7-phosphate isomerase
    Primary source
    ECOCYC:G6106
    Locus tag
    b0222
    See related
    ASAP:ABE-0000751
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0223; lpcA; tfrA; yafI
    Summary
    Sedoheptulose 7-phosphate isomerase catalyzes the first committed step in the biosynthesis of a core component of lipopolysaccharide, the isomerization of D-sedoheptulose 7-phosphate to D-glycero-D-manno-heptose 7-phosphate. [More information is available at EcoCyc: G6106].
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    Genomic context

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    Sequence:
    NC_000913.3 (243543..244121)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene periplasmic chaperone, inhibitor of vertebrate C-type lysozyme Neighboring gene acyl-CoA dehydrogenase Neighboring gene putative glutamine amidotransferase YafJ Neighboring gene peptidoglycan meso-diaminopimelic acid protein amidase A Neighboring gene ribosome-dependent mRNA interferase toxin YafQ

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Conjugation deficient E. coli K12 F- mutants with heptose-less lipopolysaccharide. Havekes LM, et al. Mol Gen Genet, 1976 Jul 5. PMID 785207
    2. Role of lipopolysaccharides in antibiotic resistance and bacteriophage adsorption of Escherichia coli K-12. Tamaki S, et al. J Bacteriol, 1971 Mar. PMID 4926688, Free PMC Article
    3. Biosynthesis of inner core lipopolysaccharide in enteric bacteria identification and characterization of a conserved phosphoheptose isomerase. Brooke JS, et al. J Biol Chem, 1996 Feb 16. PMID 8631969
    4. An in vitro screen of bacterial lipopolysaccharide biosynthetic enzymes identifies an inhibitor of ADP-heptose biosynthesis. De Leon GP, et al. Chem Biol, 2006 Apr. PMID 16632256
    5. Study of the early response of Escherichia coli lpcA and ompF mutants to ciprofloxacin. Tyulenev AV, et al. Res Microbiol, 2022 Jul-Sep. PMID 35568342

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study of the early response of Escherichia coli lpcA and ompF mutants to ciprofloxacin.
      Title: Study of the early response of Escherichia coli lpcA and ompF mutants to ciprofloxacin.
    2. GmhA adopts two distinct conformations during isomerization through reorganization of quaternary structure.
      Title: Structure and function of sedoheptulose-7-phosphate isomerase, a critical enzyme for lipopolysaccharide biosynthesis and a target for antibiotic adjuvants.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables D-sedoheptulose 7-phosphate isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables D-sedoheptulose 7-phosphate isomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables D-sedoheptulose 7-phosphate isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carbohydrate derivative binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in D-glycero-D-manno-heptose 7-phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within D-glycero-D-manno-heptose 7-phosphate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in D-glycero-D-manno-heptose 7-phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in carbohydrate derivative metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipopolysaccharide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipopolysaccharide core region biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipopolysaccharide core region biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein homotetramerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    D-sedoheptulose 7-phosphate isomerase
    NP_414757.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      243543..244121
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414757.1 D-sedoheptulose 7-phosphate isomerase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414757.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A895NW66
      Conserved Domains (1) summary
      PRK00414
      Location:1 → 192
      gmhA; D-sedoheptulose 7-phosphate isomerase
    Nucleotide Protein
    Heading Accession and Version

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