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    mrdB peptidoglycan glycosyltransferase MrdB [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945238, updated on 17-Dec-2024

    Summary

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    Official Symbol
    mrdB
    Official Full Name
    peptidoglycan glycosyltransferase MrdB
    Primary source
    ECOCYC:EG10607
    Locus tag
    b0634
    See related
    ASAP:ABE-0002173
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0627; rodA
    Summary
    The rodA gene encodes the RodA protein responsible for maintaining the rod cell shape and mecillinam sensitivity in Escherichia coli along with pbpA, which encodes PBP2 , . [More information is available at EcoCyc: EG10607].
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    Genomic context

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    Sequence:
    NC_000913.3 (665201..666313, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene D-alanyl-D-alanine carboxypeptidase DacA Neighboring gene rare lipoprotein RlpA Neighboring gene peptidoglycan DD-transpeptidase MrdA Neighboring gene 23S rRNA m(3)psi1915 methyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural basis of peptidoglycan synthesis by E. coli RodA-PBP2 complex. Nygaard R, et al. Nat Commun, 2023 Aug 24. PMID 37620344, Free PMC Article
    2. The life-cycle proteins RodA of Escherichia coli and SpoVE of Bacillus subtilis have very similar primary structures. Joris B, et al. Mol Microbiol, 1990 Mar. PMID 2113157
    3. Interaction between membrane proteins PBP3 and rodA is required for normal cell shape and division in Escherichia coli. Begg KJ, et al. J Bacteriol, 1986 Sep. PMID 3017915, Free PMC Article
    4. Characterization and genetic analysis of a mutant of Escherichia coli K-12 with rounded morphology. Matsuzawa H, et al. J Bacteriol, 1973 Jul. PMID 4577747, Free PMC Article
    5. Division planes alternate in spherical cells of Escherichia coli. Begg KJ, et al. J Bacteriol, 1998 May. PMID 9573213, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Genetic analysis of the septal peptidoglycan synthase FtsWI complex supports a conserved activation mechanism for SEDS-bPBP complexes.
      Title: Genetic analysis of the septal peptidoglycan synthase FtsWI complex supports a conserved activation mechanism for SEDS-bPBP complexes.
    2. MreC and MreD balance the interaction between the elongasome proteins PBP2 and RodA.
      Title: MreC and MreD balance the interaction between the elongasome proteins PBP2 and RodA.
    3. Mutations in mreB, mrdA and mrdB suppress the shape defect of RodZ-deficient cells.
      Title: Mutations in cell elongation genes mreB, mrdA and mrdB suppress the shape defect of RodZ-deficient cells.
    4. Cells lacking mrdB were fully viable and propagated as small spheres under conditions of slow mass increase but formed large nondividing spheroids with noncanonical FtsZ assembly patterns at higher mass doubling rates.
      Title: Conditional lethality, division defects, membrane involution, and endocytosis in mre and mrd shape mutants of Escherichia coli.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipid-linked peptidoglycan transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidoglycan glycosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptidoglycan glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell division IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell wall organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid-linked peptidoglycan transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within peptidoglycan biosynthetic process EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in peptidoglycan biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in peptidoglycan biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptidoglycan biosynthetic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in peptidoglycan-based cell wall organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of cell shape EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in regulation of cell shape IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell shape IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of cell shape IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell shape IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell shape NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cell division site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    peptidoglycan glycosyltransferase MrdB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      665201..666313 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415167.1 peptidoglycan glycosyltransferase MrdB [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415167.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5B9AP60, A0A6C9Q8R8
      Conserved Domains (1) summary
      PRK10794
      Location:1 → 370
      PRK10794; rod shape-determining protein RodA
    Nucleotide Protein
    Heading Accession and Version

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