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    lysO L-lysine/thialysine exporter [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947142, updated on 3-Dec-2024

    Summary

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    Official Symbol
    lysO
    Official Full Name
    L-lysine/thialysine exporter
    Primary source
    ECOCYC:G6458
    Locus tag
    b0874
    See related
    ASAP:ABE-0002966
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0865; ybjE
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    Genomic context

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    Sequence:
    NC_000913.3 (913958..914857, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene NADH oxidoreductase Neighboring gene protein S-nitrosylase Neighboring gene water channel AqpZ Neighboring gene DUF2813 domain-containing protein YbjD Neighboring gene DUF535 domain-containing protein YbjX

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Topological analyses of the L-lysine exporter LysO reveal a critical role for a conserved pair of intramembrane solvent-exposed acidic residues. Dubey S, et al. J Biol Chem, 2021 Oct. PMID 34487760, Free PMC Article
    2. Distinct Paths for Basic Amino Acid Export in Escherichia coli: YbjE (LysO) Mediates Export of L-Lysine. Pathania A, et al. J Bacteriol, 2015 Jun 15. PMID 25845847, Free PMC Article
    3. Global topology analysis of the Escherichia coli inner membrane proteome. Daley DO, et al. Science, 2005 May 27. PMID 15919996
    4. The binary protein-protein interaction landscape of Escherichia coli. Rajagopala SV, et al. Nat Biotechnol, 2014 Mar. PMID 24561554, Free PMC Article
    5. Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Hayashi K, et al. Mol Syst Biol, 2006. PMID 16738553, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Topological analyses of the L-lysine exporter LysO reveal a critical role for a conserved pair of intramembrane solvent-exposed acidic residues.
      Title: Topological analyses of the L-lysine exporter LysO reveal a critical role for a conserved pair of intramembrane solvent-exposed acidic residues.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables L-lysine efflux transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-lysine efflux transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables L-lysine efflux transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in L-lysine transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within L-lysine transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    L-lysine/thialysine exporter

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      913958..914857 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415395.2 L-lysine/thialysine exporter [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415395.2

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7E6D1
      Conserved Domains (1) summary
      COG2431
      Location:1 → 299
      YbjE; Uncharacterized membrane protein YbjE, DUF340 family [Function unknown]
    Nucleotide Protein
    Heading Accession and Version

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