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    mreD cell shape determining protein MreD [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947756, updated on 3-Dec-2024

    Summary

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    Official Symbol
    mreD
    Official Full Name
    cell shape determining protein MreD
    Primary source
    ECOCYC:EG10610
    Locus tag
    b3249
    See related
    ASAP:ABE-0010656
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3237
    Summary
    [More information is available at EcoGene: EG10610]. The mre genes are responsible for rod shape and mecillinam sensitivity in Escherichia coli . [More information is available at EcoCyc: EG10610].
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    Genomic context

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    Sequence:
    NC_000913.3 (3398387..3398875, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene phospholipid transport factor YhdP Neighboring gene RNase G Neighboring gene nucleoside triphosphate pyrophosphatase YhdE Neighboring gene cell shape determining protein MreC Neighboring gene dynamic cytoskeletal protein MreB Neighboring gene regulator of CsrB and CsrC decay

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Formate auxotroph of Methanobacterium thermoautotrophicum Marburg. Tanner RS, et al. J Bacteriol, 1989 Dec. PMID 2687241, Free PMC Article
    2. Duplication and segregation of the actin (MreB) cytoskeleton during the prokaryotic cell cycle. Vats P, et al. Proc Natl Acad Sci U S A, 2007 Nov 6. PMID 17978175, Free PMC Article
    3. Bacterial DNA segregation by the actin-like MreB protein. Kruse T, et al. Trends Cell Biol, 2005 Jul. PMID 15922599
    4. MreB, the cell shape-determining bacterial actin homologue, co-ordinates cell wall morphogenesis in Caulobacter crescentus. Figge RM, et al. Mol Microbiol, 2004 Mar. PMID 14982627
    5. Transcriptional analysis of the Escherichia coli mreBCD genes responsible for morphogenesis and chromosome segregation. Wachi M, et al. Biosci Biotechnol Biochem, 2006 Nov. PMID 17090951

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MreC and MreD balance the interaction between the elongasome proteins PBP2 and RodA.
      Title: MreC and MreD balance the interaction between the elongasome proteins PBP2 and RodA.
    2. Cells lacking mreD were fully viable and propagated as small spheres under conditions of slow mass increase but formed large nondividing spheroids with noncanonical FtsZ assembly patterns at higher mass doubling rates.
      Title: Conditional lethality, division defects, membrane involution, and endocytosis in mre and mrd shape mutants of Escherichia coli.
    3. We found that cells depleted of mreBCD became spherical, enlarged and finally lysed. Depletion of each mre gene separately conferred similar gross changes in cell morphology and viability.
      Title: The morphogenetic MreBCD proteins of Escherichia coli form an essential membrane-bound complex.
    4. three promoters contributed to the expression of mreBCD
      Title: Transcriptional analysis of the Escherichia coli mreBCD genes responsible for morphogenesis and chromosome segregation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in peptidoglycan biosynthetic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of cell shape EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in regulation of cell shape IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell shape IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of cell shape IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell shape NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cell shape determining protein MreD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3398387..3398875 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417715.1 cell shape determining protein MreD [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417715.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5B9APZ2
      Conserved Domains (1) summary
      PRK11060
      Location:1 → 162
      PRK11060; rod shape-determining protein MreD; Provisional
    Nucleotide Protein
    Heading Accession and Version

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