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    coaD pantetheine-phosphate adenylyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947386, updated on 3-Dec-2024

    Summary

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    Official Symbol
    coaD
    Official Full Name
    pantetheine-phosphate adenylyltransferase
    Primary source
    ECOCYC:EG11190
    Locus tag
    b3634
    See related
    ASAP:ABE-0011875
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3624; kdtB; yicA
    Summary
    Phosphopantetheine adenylyltransferase (PPAT) catalyzes the transfer of an adenyly group from ATP to 4'-phosphopantetheine . [More information is available at EcoCyc: EG11190].
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    Genomic context

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    Sequence:
    NC_000913.3 (3809825..3810304)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene KDO transferase Neighboring gene DNA-formamidopyrimidine glycosylase Neighboring gene 50S ribosomal subunit protein L33

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The crystal structure of a novel bacterial adenylyltransferase reveals half of sites reactivity. Izard T, et al. EMBO J, 1999 Apr 15. PMID 10205156, Free PMC Article
    2. A novel adenylate binding site confers phosphopantetheine adenylyltransferase interactions with coenzyme A. Izard T. J Bacteriol, 2003 Jul. PMID 12837781, Free PMC Article
    3. Inhibitors of phosphopantetheine adenylyltransferase. Zhao L, et al. Eur J Med Chem, 2003 Apr. PMID 12750020
    4. Cubic crystals of phosphopantetheine adenylyltransferase from Escherichia coli. Izard T, et al. Acta Crystallogr D Biol Crystallogr, 1999 Jun. PMID 10329792
    5. Phosphopantetheine adenylyltransferase from Escherichia coli: investigation of the kinetic mechanism and role in regulation of coenzyme A biosynthesis. Miller JR, et al. J Bacteriol, 2007 Nov. PMID 17873050, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The steady-state kinetics and ligand binding properties of coaD in the biosynthesis of coenzyme A are reported.
      Title: Phosphopantetheine adenylyltransferase from Escherichia coli: investigation of the kinetic mechanism and role in regulation of coenzyme A biosynthesis.
    2. N-terminus verified by Edman degradation on complete protein
      Title: Purification and characterization of phosphopantetheine adenylyltransferase from Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pantetheine-phosphate adenylyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pantetheine-phosphate adenylyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pantetheine-phosphate adenylyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in coenzyme A biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within coenzyme A biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in coenzyme A biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    pantetheine-phosphate adenylyltransferase
    NP_418091.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3809825..3810304
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418091.1 pantetheine-phosphate adenylyltransferase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418091.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5B9AXD3
      Conserved Domains (1) summary
      PRK00168
      Location:3 → 159
      coaD; phosphopantetheine adenylyltransferase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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