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    copA Cu(+) exporting P-type ATPase;soluble Cu(+) chaperone [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946106, updated on 3-Dec-2024

    Summary

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    Official Symbol
    copA
    Official Full Name
    Cu(+) exporting P-type ATPase;soluble Cu(+) chaperone
    Primary source
    ECOCYC:G6260
    Locus tag
    b0484
    See related
    ASAP:ABE-0001681
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0478; ybaR
    Summary
    Upregulated by GSNO in defined medium (anaerobic). [More information is available at EcoGene: EG13246]. CopA is a member of the P-type ATPase cation transporter family and is involved in copper homeostasis as an ATP-dependent exporter of monovalent copper under primarily aerobic conditions . [More information is available at EcoCyc: G6260].
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    Genomic context

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    Sequence:
    NC_000913.3 (508875..511379, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene TraB family protein YbaP Neighboring gene DNA-binding transcriptional regulator YbaQ Neighboring gene glutaminase 1 Neighboring gene putative transporter YbaT

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Programmed Ribosomal Frameshifting Generates a Copper Transporter and a Copper Chaperone from the Same Gene. Meydan S, et al. Mol Cell, 2017 Jan 19. PMID 28107647, Free PMC Article
    2. Distinct functions of serial metal-binding domains in the Escherichia coli P1 B -ATPase CopA. Drees SL, et al. Mol Microbiol, 2015 Aug. PMID 25899340
    3. P-type ATPases of eukaryotes and bacteria: sequence analyses and construction of phylogenetic trees. Fagan MJ, et al. J Mol Evol, 1994 Jan. PMID 8151716
    4. CopA: An Escherichia coli Cu(I)-translocating P-type ATPase. Rensing C, et al. Proc Natl Acad Sci U S A, 2000 Jan 18. PMID 10639134, Free PMC Article
    5. Biochemical characterization of CopA, the Escherichia coli Cu(I)-translocating P-type ATPase. Fan B, et al. J Biol Chem, 2002 Dec 6. PMID 12351646

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CopA chaperone is expressed in E. coli from the same gene that encodes the transporter. Some ribosomes translating copA undergo programmed frameshifting, terminate translation in the -1 frame, and generate the 70 aa-long polypeptide CopA(Z), which helps cells survive toxic copper concentrations. The high efficiency of frameshifting is achieved by the combined stimulatory action of a "slippery" sequence, an mRNA pseudoknot
      Title: Programmed Ribosomal Frameshifting Generates a Copper Transporter and a Copper Chaperone from the Same Gene.
    2. The distal N-terminal metal-binding domain transfers copper to the membrane-integral ion-binding sites of CopA, while the proximal metal-binding domain has a regulatory role by suppressing the catalytic activity of CopA in absence of copper.
      Title: Distinct functions of serial metal-binding domains in the Escherichia coli P1 B -ATPase CopA.
    3. Data indicate that RNAP sigma(70)-can bind to copper efflux regulator (CueR)-promoter PcopA complex.
      Title: Metalloregulator CueR biases RNA polymerase's kinetic sampling of dead-end or open complex to repress or activate transcription.
    4. copper-transporting ATPases, CopA and ATP7A, in both bacteria and macrophage are unique determinants of bacteria survival and identify an unexpected role for copper at the host-pathogen interface
      Title: A role for the ATP7A copper-transporting ATPase in macrophage bactericidal activity.
    5. N-terminus verified by Edman degradation on mature peptide
      Title: Small genes/gene-products in Escherichia coli K-12.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled monoatomic cation transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables P-type divalent copper transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables P-type ion transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables P-type monovalent copper transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables copper ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in copper ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in copper ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in copper ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic cation transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic cation transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in viral translational frameshifting IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane HDA PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cu(+) exporting P-type ATPase;soluble Cu(+) chaperone

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      508875..511379 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415017.1 Cu(+) exporting P-type ATPase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415017.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6M9WTC3
      Conserved Domains (1) summary
      PRK10671
      Location:1 → 834
      copA; copper-exporting P-type ATPase CopA

    2. YP_009518752.1 soluble Cu(+) chaperone [Escherichia coli str. K-12 substr. MG1655]

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6D0ICQ1
      Conserved Domains (1) summary
      cl27747
      Location:1 → 69
      E1-E2_ATPase; E1-E2 ATPase
    Nucleotide Protein
    Heading Accession and Version

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