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    fepE polysaccharide co-polymerase family protein FepE [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945180, updated on 17-Dec-2024

    Summary

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    Official Symbol
    fepE
    Official Full Name
    polysaccharide co-polymerase family protein FepE
    Primary source
    ECOCYC:EG10297
    Locus tag
    b0587
    See related
    ASAP:ABE-0002023
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0580
    Summary
    FepE is believed to be a component of the ferric enterobactin transport system, because mutation of fepE disrupts uptake of enterobactin . [More information is available at EcoCyc: EG10297].
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    Genomic context

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    Sequence:
    NC_000913.3 (618254..619387)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene ferric enterobactin esterase Neighboring gene enterobactin biosynthesis protein YbdZ Neighboring gene apo-serine activating enzyme Neighboring gene ferric enterobactin ABC transporter ATP binding subunit Neighboring gene ferric enterobactin ABC transporter membrane subunit FepG Neighboring gene ferric enterobactin ABC transporter membrane subunit FebD Neighboring gene enterobactin exporter EntS

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sequence-structure relationships in polysaccharide co-polymerase (PCP) proteins. Morona R, et al. Trends Biochem Sci, 2009 Feb. PMID 19058968
    2. Bacterial polysaccharide co-polymerases share a common framework for control of polymer length. Tocilj A, et al. Nat Struct Mol Biol, 2008 Feb. PMID 18204465
    3. Biosynthesis of the Escherichia coli siderophore enterobactin: sequence of the entF gene, expression and purification of EntF, and analysis of covalent phosphopantetheine. Rusnak F, et al. Biochemistry, 1991 Mar 19. PMID 1826089
    4. Promoter and operator determinants for fur-mediated iron regulation in the bidirectional fepA-fes control region of the Escherichia coli enterobactin gene system. Hunt MD, et al. J Bacteriol, 1994 Jul. PMID 8021177, Free PMC Article
    5. Inducible serum resistance in Salmonella typhimurium is dependent on wzz(fepE)-regulated very long O antigen chains. Murray GL, et al. Microbes Infect, 2005 Oct. PMID 16027021

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ferric-enterobactin transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within ferric-enterobactin import into cell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in iron ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    polysaccharide co-polymerase family protein FepE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      618254..619387
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415119.1 polysaccharide co-polymerase family protein FepE [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415119.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      W1F3A7
      Conserved Domains (1) summary
      PRK10381
      Location:1 → 377
      PRK10381; LPS O-antigen length regulator; Provisional
    Nucleotide Protein
    Heading Accession and Version

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