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    rng RNase G [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947744, updated on 3-Dec-2024

    Summary

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    Official Symbol
    rng
    Official Full Name
    RNase G
    Primary source
    ECOCYC:EG11299
    Locus tag
    b3247
    See related
    ASAP:ABE-0010651
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    adhR; cafA; ECK3235; yhdF
    Summary
    The rng gene encodes RNAse G , which acts in maturation of the 5' end of 16S rRNA . [More information is available at EcoCyc: EG11299].
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    Genomic context

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    Sequence:
    NC_000913.3 (3396326..3397795, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene metalloprotease subunit TldD Neighboring gene phospholipid transport factor YhdP Neighboring gene nucleoside triphosphate pyrophosphatase YhdE Neighboring gene cell shape determining protein MreD Neighboring gene cell shape determining protein MreC Neighboring gene dynamic cytoskeletal protein MreB

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The function of RNase G in Escherichia coli is constrained by its amino and carboxyl termini. Deana A, et al. Mol Microbiol, 2004 Feb. PMID 14763991
    2. RNA processing: new mutants that affect endonucleolytic processing of RNA. Miczak A, et al. Biochem Biophys Res Commun, 1983 Jul 29. PMID 6192822
    3. Single amino acid changes in the predicted RNase H domain of Escherichia coli RNase G lead to complementation of RNase E deletion mutants. Chung DH, et al. RNA, 2010 Jul. PMID 20507976, Free PMC Article
    4. The sequence of sites recognised by a member of the RNase E/G family can control the maximal rate of cleavage, while a 5'-monophosphorylated end appears to function cooperatively in mediating RNA binding. Jourdan SS, et al. Biochem Biophys Res Commun, 2010 Jan 1. PMID 19945430
    5. The quaternary structure of RNase G from Escherichia coli. Briant DJ, et al. Mol Microbiol, 2003 Nov. PMID 14622423

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RNase G cleaves the 5' untranslated region of triosephosphate isomerase A (tpiA) mRNA, leading to destabilization of the mRNA in E. coli.
      Title: RNase G controls tpiA mRNA abundance in response to oxygen availability in Escherichia coli.
    2. 2 distinct spontaneously derived single amino acid substitutions within the predicted RNase H domain of RNase G, generating the rng-219 and rng-248 alleles, result in complementation of the growth defect associated with various RNase E mutants.
      Title: Single amino acid changes in the predicted RNase H domain of Escherichia coli RNase G lead to complementation of RNase E deletion mutants.
    3. Escherichia coli RNase G sensing a 5' monophosphate is required in vivo for the normal rapid decay of functional mRNAs.
      Title: Sensing of 5' monophosphate by Escherichia coli RNase G can significantly enhance association with RNA and stimulate the decay of functional mRNA transcripts in vivo.
    4. N-terminus verified by Edman degradation on mature peptide
      Title: Cytoplasmic axial filaments in Escherichia coli cells: possible function in the mechanism of chromosome segregation and cell division.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA nuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables rRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribonuclease G activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within maturation of SSU-rRNA IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within maturation of SSU-rRNA IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within rRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RNase G

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3396326..3397795 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417713.2 RNase G [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417713.2

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A418GIW5, A0A8S7MYY8
      Conserved Domains (1) summary
      PRK11712
      Location:1 → 489
      PRK11712; ribonuclease G; Provisional
    Nucleotide Protein
    Heading Accession and Version

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