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    fumC fumarase C [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946147, updated on 17-Dec-2024

    Summary

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    Official Symbol
    fumC
    Official Full Name
    fumarase C
    Primary source
    ECOCYC:EG10358
    Locus tag
    b1611
    See related
    ASAP:ABE-0005380
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1606
    Summary
    SoxRS regulon. [More information is available at EcoGene: EG10358]. One of three isozymes in Escherichia coli, fumarase C is a Class II fumarase. [More information is available at EcoCyc: EG10358].
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    Genomic context

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    Sequence:
    NC_000913.3 (1685185..1686588, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional regulator RstA Neighboring gene sensory histidine kinase RstB Neighboring gene DNA replication terminus site-binding protein Neighboring gene fumarase A Neighboring gene mannose-6-phosphate isomerase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolving dual targeting of a prokaryotic protein in yeast. Burak E, et al. Mol Biol Evol, 2013 Jul. PMID 23462316
    2. Closed fumarase C active-site structures reveal SS Loop residue contribution in catalysis. Stuttgen GM, et al. FEBS Lett, 2020 Jan. PMID 31514245
    3. The multisubunit active site of fumarase C from Escherichia coli. Weaver TM, et al. Nat Struct Biol, 1995 Aug. PMID 7552727
    4. Structure of free fumarase C from Escherichia coli. Weaver T. Acta Crystallogr D Biol Crystallogr, 2005 Oct. PMID 16204892
    5. The role of the allosteric B site in the fumarase reaction. Rose IA, et al. Proc Natl Acad Sci U S A, 2004 Mar 9. PMID 14990798, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. we report structural and kinetic analyses from Escherichia coli FumC variants to understand the contribution of SS Loop residues S318, K324, and N326. High-resolution X-ray crystallographic results reveal three distinct FumC active-site conformations; disordered-open, ordered-open, and the newly discovered ordered-closed.
      Title: Closed fumarase C active-site structures reveal SS Loop residue contribution in catalysis.
    2. Starting with an exclusively mitochondrial targeted FumC (attached to a strong MTS), we show that two randomly acquired mutations within the prokaryotic FumC sequence are sufficient to cause substantial dual targeting by reverse translocation
      Title: Evolving dual targeting of a prokaryotic protein in yeast.
    3. The results show that Crp is an activator of fumA and fumC gene expression under various oxygen conditions and growth rates.
      Title: Regulatory role of cAMP receptor protein over Escherichia coli fumarase genes.
    4. N-terminus verified by Edman degradation on complete protein
      Title: Purification and crystallization of fumarase C from Escherichia coli.
    5. water is a permanent member of the active site of FumC, which uses an imidazole-imidazolium conversion to control access at the allosteric B site
      Title: Structure of free fumarase C from Escherichia coli.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables fumarate hydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fumarate hydratase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables fumarate hydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fumarate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fumarate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in malate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within response to oxidative stress IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in tricarboxylic acid cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    fumarase C
    NP_416128.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1685185..1686588 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416128.1 fumarase C [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416128.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A478KXS2
      Conserved Domains (1) summary
      PRK00485
      Location:1 → 464
      fumC; fumarate hydratase; Reviewed
    Nucleotide Protein
    Heading Accession and Version

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