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    hyfB hydrogenase 4 component B [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946961, updated on 3-Dec-2024

    Summary

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    Official Symbol
    hyfB
    Official Full Name
    hydrogenase 4 component B
    Primary source
    ECOCYC:EG11282
    Locus tag
    b2482
    See related
    ASAP:ABE-0008181
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2478; yffF
    Summary
    On the basis of sequence similarity to hycBCDEFG, which encodes hydrogenase 3, the ten-gene cluster hyfABCDEFGHIJ was presumed to encode a hydrogenase that interacts with formate dehydrogenase (FdhF) to produce an active formate hydrogenlyase complex. [More information is available at EcoCyc: EG11282].
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    Genomic context

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    Sequence:
    NC_000913.3 (2601818..2603836)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative transcriptional regulator GcvR Neighboring gene thiol peroxidase Neighboring gene hydrogenase 4 component A Neighboring gene hydrogenase 4 component C Neighboring gene hydrogenase 4 component D

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A molecular analysis of the 53.3 minute region of the Escherichia coli linkage map. Andrews SC, et al. J Gen Microbiol, 1991 Feb. PMID 2016588
    2. Dissecting the roles of Escherichia coli hydrogenases in biohydrogen production. Redwood MD, et al. FEMS Microbiol Lett, 2008 Jan. PMID 17995952
    3. Transcriptional control of hydrogen production during mixed carbon fermentation by hydrogenases 4 (hyf) and 3 (hyc) in Escherichia coli. Trchounian K. Gene, 2012 Sep 10. PMID 22771922
    4. Participation of hyf-encoded hydrogenase 4 in molecular hydrogen release coupled with proton-potassium exchange in Escherichia coli. Bagramyan K, et al. Membr Cell Biol, 2001. PMID 11817571
    5. Phosphorylation of ribosomal proteins in HeLa cells infected with vaccinia virus. Kaerlein M, et al. Nature, 1976 Jan 15. PMID 1246353

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables NADH dehydrogenase (ubiquinone) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ATP synthesis coupled electron transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in anaerobic electron transport chain NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in anaerobic respiration NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in formate oxidation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in glucose catabolic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of [Ni-Fe] hydrogenase complex RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    part_of formate dehydrogenase complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    hydrogenase 4 component B

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2601818..2603836
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416977.1 hydrogenase 4 component B [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416977.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6N8QSF8
      Conserved Domains (1) summary
      PRK06521
      Location:1 → 671
      PRK06521; hydrogenase 4 subunit B; Validated
    Nucleotide Protein
    Heading Accession and Version

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