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    rarA replication-associated recombination protein A [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945505, updated on 17-Dec-2024

    Summary

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    Official Symbol
    rarA
    Official Full Name
    replication-associated recombination protein A
    Primary source
    ECOCYC:EG12690
    Locus tag
    b0892
    See related
    ASAP:ABE-0003034
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0883; mgsA; ycaJ
    Summary
    AFMB Structural Genomics target Number 8 (http://afmb.cnrs-mrs.fr/article171. [More information is available at EcoGene: EG12690]. The RarA protein may play a role in recombination associated with DNA replication. [More information is available at EcoCyc: EG12690].
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    Genomic context

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    Sequence:
    NC_000913.3 (937994..939337)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene cell division DNA translocase FtsK Neighboring gene outer membrane lipoprotein carrier protein Neighboring gene serine--tRNA ligase Neighboring gene dimethyl sulfoxide reductase subunit A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RecA-independent recombination: Dependence on the Escherichia coli RarA protein. Jain K, et al. Mol Microbiol, 2021 Jun. PMID 33247976, Free PMC Article
    2. DNA flap creation by the RarA/MgsA protein of Escherichia coli. Stanage TH, et al. Nucleic Acids Res, 2017 Mar 17. PMID 28053120, Free PMC Article
    3. Cloning and characterization of the gene for Escherichia coli seryl-tRNA synthetase. Härtlein M, et al. Nucleic Acids Res, 1987 Feb 11. PMID 3029694, Free PMC Article
    4. Escherichia coli DNA polymerase III tau- and gamma-subunit conserved residues required for activity in vivo and in vitro. Walker JR, et al. J Bacteriol, 2000 Nov. PMID 11029431, Free PMC Article
    5. Recombination and chromosome segregation. Sherratt DJ, et al. Philos Trans R Soc Lond B Biol Sci, 2004 Jan 29. PMID 15065657, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The rarA gene as part of an expanded RecFOR recombination pathway: Negative epistasis and synthetic lethality with ruvB, recG, and recQ.
      Title: The rarA gene as part of an expanded RecFOR recombination pathway: Negative epistasis and synthetic lethality with ruvB, recG, and recQ.
    2. RecA-independent recombination: Dependence on the Escherichia coli RarA protein.
      Title: RecA-independent recombination: Dependence on the Escherichia coli RarA protein.
    3. At double-stranded DNA ends, RarA can couple the energy of ATP binding and hydrolysis to separating the strands of duplex DNA, creating flaps
      Title: DNA flap creation by the RarA/MgsA protein of Escherichia coli.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent activity, acting on DNA IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables single-stranded DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA duplex unwinding IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA recombination IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA synthesis involved in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA-templated DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within DNA-templated DNA replication IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within protein homotetramerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of replisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    replication-associated recombination protein A

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      937994..939337
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415412.1 replication-associated recombination protein A [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415412.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6C9Q7E9, A0A8T5YB88
      Conserved Domains (1) summary
      PRK13342
      Location:15 → 439
      PRK13342; recombination factor protein RarA; Reviewed
    Nucleotide Protein
    Heading Accession and Version

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