hns DNA-binding transcriptional dual regulator H-NS [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

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Official Symbol: hns
Official Full Name: DNA-binding transcriptional dual regulator H-NS
Primary source: ECOCYC:EG10457
Locus tag: b1237
See related: ASAP:ABE-0004152
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: B1; bglY; cur; drc; drdX; drs; ECK1232; fimG; H1; hnsA; irk; msyA; osmZ; pilG; topS; topX; virR
Summary: HN-S forms heteromeric complexes with Hha and Cnu, which modulates HN-S function, expression and stability. [More information is available at EcoGene: EG10457]. Heat-stable nucleoid-structuring protein (H-NS) is a nucleoid-associated protein that acts as a transcriptional repressor and may serve to generally suppress horizontally acquired genes. [More information is available at EcoCyc: EG10457].
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Genomic context

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Sequence:: NC_000913.3 (1292509..1292922, complement)

NC_000913.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RfaH Counter-Silences Inhibition of Transcript Elongation by H-NS-StpA Nucleoprotein Filaments in Pathogenic Escherichia coli.
Title: RfaH Counter-Silences Inhibition of Transcript Elongation by H-NS-StpA Nucleoprotein Filaments in Pathogenic Escherichia coli.
Hierarchy of transcription factor network in Escherichia coli K-12: H-NS-mediated silencing and Anti-silencing by global regulators.
Title: Hierarchy of transcription factor network in Escherichia coli K-12: H-NS-mediated silencing and Anti-silencing by global regulators.
H-NS, IHF, and DnaA lead to changes in nucleoid organizations, replication initiation, and cell division.
Title: H-NS, IHF, and DnaA lead to changes in nucleoid organizations, replication initiation, and cell division.
It has been found that H-NS showed growth phase-dependent relocalization in response to hyperosmotic shock.
Title: Growth Phase-Dependent Chromosome Condensation and Heat-Stable Nucleoid-Structuring Protein Redistribution in Escherichia coli under Osmotic Stress.
The results show that high-expression clones carry insertions that are not correlated with HNS binding. Conversely, binding of H-NS correlates with transgene silencing.
Title: Early fate of exogenous promoters in E. coli.
H-NS specifically represses LEE5 promoter activity and Ler alleviates the repression by H-NS.
Title: The mechanism underlying Ler-mediated alleviation of gene repression by H-NS.
Transcription and stability of cas3 in Deltahns cells is limiting for resistance to phage.
Title: Cas3 is a limiting factor for CRISPR-Cas immunity in Escherichia coli cells lacking H-NS.
we propose that, during E. coli evolution, the conservation of H-NS binding sites resulted in the diversification of the regulation of horizontally transferred genes, which may have facilitated E. coli adaptation to new ecological niches
Title: H-NS Facilitates Sequence Diversification of Horizontally Transferred DNAs during Their Integration in Host Chromosomes.
Through DNA binding, the two proteins interplay to form a transient ternary complex Fpg/DNA/HU which results in the release of Fpg and the molecular entrapment of SSBs by HU
Title: The nucleoid-associated protein HU enhances 8-oxoguanine base excision by the formamidopyrimidine-DNA glycosylase.
The fdeC gene encodes a protein that is expressed at the cell surface and promotes biofilm formation under continuous-flow conditions and is repressed by the global regulator H-NS.
Title: The Intimin-Like Protein FdeC Is Regulated by H-NS and Temperature in Enterohemorrhagic Escherichia coli.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by EcoCyc

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription repressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity	IPI Inferred from Physical Interaction more info	PubMed
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables bent DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables bent DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables minor groove of adenine-thymine-rich DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables structural constituent of chromatin	IEA Inferred from Electronic Annotation more info
enables transcription cis-regulatory region binding	IBA Inferred from Biological aspect of Ancestor more info
enables transcription cis-regulatory region binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in bacterial nucleoid packaging	IDA Inferred from Direct Assay more info	PubMed
involved_in bacterial nucleoid packaging	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of DNA-templated transcription	EXP Inferred from Experiment more info	PubMed
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within negative regulation of single-species biofilm formation on inanimate substrate	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of H-NS complex	IPI Inferred from Physical Interaction more info	PubMed
part_of H-NS-Cnu complex	IPI Inferred from Physical Interaction more info	PubMed
part_of H-NS-Hha complex	IPI Inferred from Physical Interaction more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	HDA more info	PubMed
located_in nucleoid	IEA Inferred from Electronic Annotation more info
part_of protein-DNA complex	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-DNA complex	IPI Inferred from Physical Interaction more info	PubMed
part_of transcription regulator complex	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: DNA-binding transcriptional dual regulator H-NS

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_000913.3 Reference assembly

Range

1292509..1292922 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NP_415753.1 DNA-binding transcriptional dual regulator H-NS [Escherichia coli str. K-12 substr. MG1655]

See identical proteins and their annotated locations for NP_415753.1

Status: PROVISIONAL

UniProtKB/TrEMBL

A0A090AZP7

Conserved Domains (1) summary

PRK10947
Location:1 → 135

PRK10947; DNA-binding transcriptional regulator H-NS