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    argP DNA-binding transcriptional dual regulator ArgP [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 944867, updated on 3-Dec-2024

    Summary

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    Official Symbol
    argP
    Official Full Name
    DNA-binding transcriptional dual regulator ArgP
    Primary source
    ECOCYC:EG10490
    Locus tag
    b2916
    See related
    ASAP:ABE-0009574
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2912; iciA
    Summary
    ArgP(IciA) is a LysR family transcriptional regulator. argP mutants are canavanine sensitive. argP is in the pho regulon. [More information is available at EcoGene: EG10490]. ArgP, "arginine protein," controls the transcription of genes involved in the arginine transport system and genes involved in DNA replication. [More information is available at EcoCyc: EG10490].
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    Genomic context

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    Sequence:
    NC_000913.3 (3059753..3060646)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene ribose-5-phosphate isomerase A Neighboring gene pseudo Neighboring gene methylmalonyl-CoA mutase Neighboring gene methylmalonyl-CoA mutase-interacting GTPase YgfD Neighboring gene methylmalonyl-CoA decarboxylase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Properties of an Escherichia coli K-12 mutant defective in the transport of arginine and ornithine. Celis TF. J Bacteriol, 1977 Jun. PMID 405374, Free PMC Article
    2. Interaction of the IciA protein with AT-rich regions in plasmid replication origins. Wei T, et al. Nucleic Acids Res, 1996 May 15. PMID 8657567, Free PMC Article
    3. Genetic defects affecting an arginine permease and repression of arginine synthesis in Escherichia coli. Maas WK. Fed Proc, 1965 Sep-Oct. PMID 5320107
    4. Basic amino acid transport in Escherichia coli. Rosen BP. J Biol Chem, 1971 Jun 10. PMID 4931309
    5. Analysis of the inhibition of growth produced by canavanine in Escherichia coli. SCHWARTZ JH, et al. J Bacteriol, 1960 Jun. PMID 14443992, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ArgP is a transcriptional regulator for lysine repression of genes and it is noncanonical in that it also exhibits low-affinity binding, without apparent direct regulatory effect, to a number of additional sites in the genome.
      Title: Role of ArgP (IciA) in lysine-mediated repression in Escherichia coli.
    2. These results indicate that ArgP is a major regulator of lysP expression but that Lrp modulates lysP transcription under lysine-limiting conditions.
      Title: Identification of ArgP and Lrp as transcriptional regulators of lysP, the gene encoding the specific lysine permease of Escherichia coli.
    3. Activation by Lrp interferes with the previously demonstrated activation of the argO promoter by ArgP.
      Title: Competitive activation of the Escherichia coli argO gene coding for an arginine exporter by the transcriptional regulators Lrp and ArgP.
    4. These results fit with a model in which ArgP contributes to enhanced transcription of dapB when lysine becomes limiting.
      Title: Lysine represses transcription of the Escherichia coli dapB gene by preventing its activation by the ArgP activator.
    5. The ArgP dimer by itself is able to bind the argO promoter-operator region to form a binary complex, but that the formation of a ternary complex with RNA polymerase is greatly stimulated only in presence of a coeffector.
      Title: Environmental regulation operating at the promoter clearance step of bacterial transcription.
    6. N-terminus verified by Edman degradation on complete protein
      Title: iciA, an Escherichia coli gene encoding a specific inhibitor of chromosomal initiation of replication in vitro.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables bent DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of DNA-templated DNA replication initiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA-binding transcriptional dual regulator ArgP

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3059753..3060646
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417391.1 DNA-binding transcriptional dual regulator ArgP [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417391.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6C9Q9L8
      Conserved Domains (1) summary
      PRK03635
      Location:3 → 295
      PRK03635; ArgP/LysG family DNA-binding transcriptional regulator
    Nucleotide Protein
    Heading Accession and Version

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