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    cysK cysteine synthase A [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946877, updated on 3-Dec-2024

    Summary

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    Official Symbol
    cysK
    Official Full Name
    cysteine synthase A
    Primary source
    ECOCYC:EG10192
    Locus tag
    b2414
    See related
    ASAP:ABE-0007957
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2409; ssi5
    Summary
    CysK forms a bienzyme complex with CysE. [More information is available at EcoGene: EG10192]. Cysteine synthase A carries out the second step in the pathway of cysteine biosynthesis, converting O-acetyl-serine into L-cysteine. [More information is available at EcoCyc: EG10192].
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    Genomic context

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    Sequence:
    NC_000913.3 (2532409..2533380)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene cell division protein ZipA Neighboring gene sulfate:H(+) symporter Neighboring gene phosphocarrier protein HPr Neighboring gene PTS enzyme I

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation and characterization of cysK mutants of Escherichia coli K12. Fimmel AL, et al. J Gen Microbiol, 1977 Nov. PMID 338862
    2. Properties of cysK mutants of Escherichia coli K12. Wiater A, et al. Acta Biochim Pol, 1979. PMID 388955
    3. Induction of the Escherichia coli cysK gene by genetic and environmental factors. Yamamoto K, et al. FEMS Microbiol Lett, 2011 Oct. PMID 22092684
    4. Location on the Escherichia coli genome of a gene specifying O-acetylserine (thiol)-lyase. Boronat A, et al. J Gen Microbiol, 1984 Mar. PMID 6374031
    5. Characteristics of serine acetyltransferase from Escherichia coli deleting different lengths of amino acid residues from the C-terminus. Mino K, et al. Biosci Biotechnol Biochem, 2000 Sep. PMID 11055390

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that bacterial serine acetyltransferase (CysE) is activated when bound to O-acetylserine sulfhydrylase-A sulfhydrylase (CysK).
      Title: Modulation of Escherichia coli serine acetyltransferase catalytic activity in the cysteine synthase complex.
    2. The authors showed that the expression of cysK is regulated by several genetic and environmental factors in addition to CysB: two genetic factors, OmpR and CysE, and lithium.
      Title: Induction of the Escherichia coli cysK gene by genetic and environmental factors.
    3. N-terminus verified by Edman degradation on mature peptide
      Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables L-cysteine desulfhydrase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-cysteine desulfhydrase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables S-carboxymethylcysteine synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cysteine synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pyridoxal phosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity, transferring alkyl or aryl (other than methyl) groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within amino acid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cysteine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cysteine biosynthetic process from serine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cysteine biosynthetic process from serine IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cysteine biosynthetic process from serine IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cysteine biosynthetic process from serine IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of cysteine synthase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cysteine synthase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cysteine synthase A
    NP_416909.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2532409..2533380
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416909.1 cysteine synthase A [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416909.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6D0IIP0, A0A6D0IIU7
      Conserved Domains (1) summary
      TIGR01139
      Location:8 → 312
      cysK; cysteine synthase A
    Nucleotide Protein
    Heading Accession and Version

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