tyrB tyrosine aminotransferase [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

Official Symbol: tyrB
Official Full Name: tyrosine aminotransferase
Primary source: ECOCYC:EG11040
Locus tag: b4054
See related: ASAP:ABE-0013278
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK4046
Summary: tyrB is in the TyrR regulon. [More information is available at EcoGene: EG11040]. Tyrosine aminotransferase (TyrB), also known as aromatic-acid aminotransferase, is a broad-specificity enzyme that catalyzes the final step in tyrosine, leucine, and phenylalanine biosynthesis. [More information is available at EcoCyc: EG11040].
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NC_000913.3 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

N-terminus verified by Edman degradation on complete protein
Title: Escherichia coli aromatic amino acid aminotransferase: characterization and comparison with aspartate aminotransferase.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables L-phenylalanine-2-oxoglutarate transaminase activity	IEA Inferred from Electronic Annotation more info
enables L-tyrosine-2-oxoglutarate transaminase activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-tyrosine-2-oxoglutarate transaminase activity	IDA Inferred from Direct Assay more info	PubMed
enables L-tyrosine-2-oxoglutarate transaminase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables aromatic-amino-acid transaminase activity	IDA Inferred from Direct Assay more info	PubMed
enables aromatic-amino-acid transaminase activity	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables pyridoxal phosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables pyridoxal phosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info
enables transaminase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within L-leucine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in L-phenylalanine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in L-phenylalanine biosynthetic process from chorismate via phenylpyruvate	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within L-phenylalanine biosynthetic process from chorismate via phenylpyruvate	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within L-tyrosine biosynthetic process from chorismate via 4-hydroxyphenylpyruvate	IDA Inferred from Direct Assay more info	PubMed
involved_in amino acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in amino acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in aromatic amino acid family biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within aspartate biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in tyrosine biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed

NP_418478.1

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