U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    apt adenine phosphoribosyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945113, updated on 3-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    apt
    Official Full Name
    adenine phosphoribosyltransferase
    Primary source
    ECOCYC:EG10051
    Locus tag
    b0469
    See related
    ASAP:ABE-0001628
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0463
    Summary
    Adenine phosphoribosyltransferase is one of the purine salvage enzymes which play an important role in maintaining nucleotide pool balance in Escherichia coli. [More information is available at EcoCyc: EG10051].
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000913.3 (491412..491963)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene primosomal replication protein N'' Neighboring gene DUF454 domain-containing inner membrane protein YbaN Neighboring gene DNA polymerase III subunit gamma;DNA polymerase III subunit tau Neighboring gene putative nucleoid-associated protein YbaB Neighboring gene recombination mediator protein RecR

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Cloning and restriction map of the E. coli apt gene. Hershey HV, et al. Gene, 1982 Jul-Aug. PMID 6292052
    2. Adenine phosphoribosyltransferase from Escherichia coli. Hochstadt J. Methods Enzymol, 1978. PMID 357906
    3. [Phenotypic manifestation of mutations involving resistance to 2,6-diaminopurine (apt) in the genome of purine auxotrophs of Escherichia coli K-12]. Kocharian ShM, et al. Genetika, 1976. PMID 793927
    4. The regulation of purine utilization in bacteria. II. Adenine phosphoribosyltransferase in isolated membrane preparations and its role in transport of adenine across the membrane. Hochstadt-Ozer J, et al. J Biol Chem, 1971 Sep 10. PMID 4328694
    5. Adenine phosphoribosyltransferase in Mycoplasma mycoides and Escherichia coli. Sin IL, et al. J Bacteriol, 1972 Oct. PMID 4562405, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A Multi-enzyme Cascade for the Biosynthesis of AICA Ribonucleoside Di- and Triphosphate.
      Title: A Multi-enzyme Cascade for the Biosynthesis of AICA Ribonucleoside Di- and Triphosphate.
    2. N-terminus verified by Edman degradation on complete protein
      Title: Oligoribonuclease is encoded by a highly conserved gene in the 3'-5' exonuclease superfamily.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables adenine phosphoribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenine phosphoribosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables adenine phosphoribosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in AMP salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within AMP salvage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in adenine salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in purine ribonucleoside salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    adenine phosphoribosyltransferase
    NP_415002.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      491412..491963
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415002.1 adenine phosphoribosyltransferase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415002.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S0FZ47
      Conserved Domains (1) summary
      PRK02304
      Location:6 → 182
      PRK02304; adenine phosphoribosyltransferase; Provisional
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.